ACTIVITIES REPORT
REGISTRY OF TUMORS IN LOWER ANIMALS :
1974 SUPPLEMENT
JOHN C. HARSHBARGER, DIRECTOR
PREPARED FOR DISTRIBUTION BY:
REGISTRY OF TUMORS IN LOWER ANIMALS
NATIONAL MUSEUM OF NATURAL HISTORY
ROOM W-216A
SMITHSONIAN INSTITUTION
WASHINGTON, D.C. 20560
JUNE 1975
a:
CONTENTS
SPECIMEN COLLECTION . . . 1
REFERENCE LIBRARY - - - - . o . . 1
TABLE I - DISTRIBUTION OF LESIONS AMONG
SPECIMENS RECEIVED . 2
PAPERS PUBLISHED SINCE THE PRECEDING
ACTIVITIES REPORT . 3
OTHER ACTIVITIES IN 1974 . . . . . . . . . 3
PERSONNEL . 4
ACCESS IONS . . . . o . o . . . . . . . . . . . 5
INDEX OF NEOPLASM - ANIMAL GROUP - AND
RTLA NUMBER . . . . . . . . . . . 25
PHYLOGENETIG INDEX - - o . c . . . » o . . . . . . 27
INDEX OF SPECIMENS BY SCIENTIFIC AND
COMMON NAMES . . . . . . . . . 30
LIST OF CONTRIBUTORS . . . . . . 34
TEAR OUT ACCESSION SHEET . . . . . . . . . . . . . . . . . . » . . » . . . . LAST PAGE
The activities of the Registry increased in all areas during 1974 due largely
to an increased concern over the effects of environmental pollution, coupled
with an increased interest in the cause and significance of neoplasia in in¬
vertebrate and cold-blooded vertebrate animals.
As pointed out in the previous activities report, copies of which are still
available, there are numerous proven and hypothesized benefits from studying
neoplasms in lower animals including the discovery of: new carcinogens, in¬
dicators of carcinogens in the environment, vectors of cancer viruses, reser¬
voirs of chemical carcinogens, multipliers of carcinogens in the food chain,
models for the study of mechanisms of neoplastic transformation, sources of
anti-cancer compounds, and models for screening the carcinogenicity and muta¬
genicity of new chemicals (less than half of the new chemicals which go into
major production each year are tested for carcinogenicity due largely to the
cost and other logistics of using the mammalian test systems),,
SPECIMEN COLLECTION
The specimen collection is the most important component of the Registry's
mission and we invite contributions of any material showing neoplasms or re¬
lated diseases in cold-blooded vertebrates and invertebrates. Almost all of
the cases received add to the information on geographic and phylogenetic dis¬
tribution of these diseases and their manifestation within the organism. In
addition, many of the cases have special significance as they relate to one
of the benefits mentioned in the previous section. Unfortunately a report
such as this does not portray the total significance of each case, but in con¬
junction with the literature it will give one a pretty good idea of where we
stand.
In 1974 the specimen collection increased by 191 accessions, which represented
an eight percent acceleration in rate over the previous reporting period. The
complete list of specimens with the diagnosis, name of contributor, and perti¬
nent reference when applicable, is included in this report. The addresses of
contributors are given at the end.
Table I gives a breakdown of the major phylogenetic groups with the ratio of
neoplastic to non-neoplastic lesions. As in previous years the bulk of the
specimens were fish and amphibians with mollusks leading the invertebrates.
Approximately two-thirds of the diagnosed material was neoplastic, but mollusca
and arthropoda continue to be the only invertebrate phyla from which verifiable
neoplasms are known.
REFERENCE LIBRARY
Approximately 300 papers were added to the comprehensive library on neoplasms
in lower animals bringing the total number to over 2,800, Except for very re¬
cent acquisitions and some older articles that need to be translated, all pa¬
pers have been abstracted by selected key words and computerized. At the con¬
clusion of a thorough editing, now in progress, the entire file will be made
available as a publication.
DISTRIBUTION OF LESIONS AMONG SPECIMENS RECEIVED
3
PAPERS PUBLISHED SINCE THE PRECEDING ACTIVITIES REPORT
Harshbarger, J<,C. Radiation, Neoplasms, Carcinogenic Chemicals, and Insects.
In; Insect Diseases, G.E. Gantwell (ed.), _2(Ghapter 8): 377-416. Marcel
Dekker, Inc.: New York. 1974.
Harshbarger, J.C. Integumentary Papillomas and Carcinomas in Fish. Symposium
No. 43: Environmental Carcinogens in Feral Aquatic Animals. In: Abstracts ;
Xlth International Cancer Congress, Florence, [Italy], 20-26 October 1974,
1: 218-219. Casa Editrice Ambrosiana; Milan. 1974.
Harshbarger, J.C. The Study of Invertebrate and Poikilothermic Vertebrate
Neoplasms by the Registry of Tumors in Lower Animals. Bull. Soc. Pharmacol.
Environ. Pathol., ^(3): 10-14. 1974.
Couch, J., Go Gardner, J.C. Harshbarger, M.R. Tripp, and P.P. Yevich. Histo¬
logical and Physiological Evaluations in Some Marine Fauna, In the Section,
"Pathological Bioassays," edited by G. La Roche of Marine Bioassays: Work¬
shop Proceedings, 1974, pp. 156-173. Marine Technology Society: Washington,
D.C. 1974.
Dawe, C.J. and J.C. Harshbarger. Neoplasms in Feral Fishes: Their Signifi¬
cance to Cancer Research. In: The Pathology of Fishes , W.E. Ribelin and G.
Migaki (ed.). Chapter 35, pp. 871-894. The University of Wisconsin Press:
Madison. 1975.
OTHER ACTIVITIES IN 1974
1. Participated in a Marine Bioassays Workshop sponsored by the Marine Tech¬
nology Society (MTS) with support from the U.S. Environmental Protection
Agency and the American Petroleum Institute (see above; paper no. 4). The
iii + 308 page Proceedings were published in 1974 and are available from MTS,
1730 M Street, N.W., Washington, D.C., 20036, for $18.00.
2. Hosted the First Marine Biomedical Workshop on 2 and 3 May 1974. The Pro¬
ceedings will not be published as a discrete unit.
3. Presented the paper, "A Gamut of Oral Neoplasms in Gunners, Tautogolabrus
adspersus , (Os teichthyes ; Perciformes; Labridae) Ranging From an Epidermal
Papilloma to an Odontogenic Ameloblastoma," at the "Symposium on Neoplasms in
Aquatic Animals as Indicators of Environmental Carcinogens" held in Cork, Ire¬
land, on 15-17 October 1974. The Symposium was sponsored by The International
Union Against Cancer (UICC) and the Proceedings will be published in Volume 21
of the Series, Progress in Experimental Tumor Research, edited by F. Homburger
for S. Karger.
4. Served as Secretary of the UICC Committee on Comparative Oncology (chaired
by C.J. Dawe of the U.S. National Cancer Institute.
5. Conducted research on integumentary neoplasms in cunners, croakers, cat¬
fish, and salamanders under the auspices of the above Committee.
> 4 -
6. Served on the Interagency Collaborative Group on Environmental Carcino¬
genesis (chaired by H.Fo Kraybill of the U.So National Cancer Institute),
7, Served as Secretary for the Society for Invertebrate Pathology.
8, Served as a member of the Committee on Animal Models and Genetic Stocks
of the National Research Council of the National Academy of Sciences.
9. Addressed the Society of Pharmacological and Environmental Pathologists
(see page 3; paper no. 3).
10, Participated in a cooperative investigation of the etiology of several
diseases of bivalve mollusks, supported in part by the U.S. Food and Drug
Administration.
11. Presented a paper (see page 3; paper no. 2) at the Xlth International Can¬
cer Congress held in Florence, Italy, on 20-26 October 1974.
PERSONNEL
The Project Officer for the contract is Dr. Clyde J. Dawe, Head, Comparative
Oncology Section, Laboratory of Pathology, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland, 20014.
The Principal Investigator for the contract is Dr. David L. Pawson, Chairman,
Department of Invertebrate Zoology, National Museum of Natural History,
Smithsonian Institution, Washington, D.C., 20560.
The staff of the Registry is as follows:
Director - John C. Harshbarger, Ph.D.
Electron Microscopist - Sing Chen Chang, Ph.D,
Registrar - Phyllis M, Schellenger, B.S.
Histopathology Technician - Linda J„ Cullen, BoA,
Bibliographers - Judith E, Foster, B.S, and Marilyn S. Slatick, B.S.
5
ACCESSIONS
RTLA 8880 Spot, Leios tomus xanthurus
Material: One gross specimen with large internal growth
Diagnosis: Microsporidian (Pleistophora sp.) granuloma
Submitter: R. Mo Overstreet
RTLA 889. Spot, Leios tomus xanthurus
Material; One gross specimen with large internal growth
Diagnosis; Microsporidian (Pleistophora sp.) granuloma
Submitter: R. M. Overstreet
RTLA 890. Spot, Leios tomus xanthurus
Material: One gross specimen with large external growth
Diagnosis; Microsporidian (Pleistophora sp.) granuloma
Submitter: R. M. Overstreet
RTLA 891. Spot,
Material:
Diagnos is :
Submitter :
Leios tomus xanthurus
One piece of tissue removed from a growth located behind
the right pectoral fin
Microsporidian (Pleistophora sp.) granuloma
R. M. Overstreet
RTLA 892. Spot, Leiostomus xanthurus
Material: One gross specimen with large internal growth
Diagnosis; Microsporidian (Pleistophora sp.) granuloma
Submitter: R. M. Overstreet
RTLA 893. Amazon molly, Poec ilia formosa
Material: Six lateral hemisections
Diagnosis: Exhuberant invasive thyroid hyperplasia versus carcinoma
visceral granulomas
Submitter: R. W„ Hart
RTLA 894. Amazon molly, Poec ilia formosa
Material; Twelve lateral hemisections
Diagnosis: Exhuberant invasive thyroid hyperplasia versus carcinoma
visceral granulomas
Submitter; R. W. Hart
RTLA 895. Amazon molly, Poec ilia formosa
Material: Eleven lateral hemisections
Diagnosis: Exhuberant invasive thyroid hyperplasia versus carcinoma
visceral granulomas
Submitter: R. W. Hart
RTLA 896. Amazon molly, Poec ilia formosa
Material: Twelve lateral hemisections
Diagnosis: Exhuberant invasive thyroid hyperplasia versus carcinoma
visceral granulomas
Submitter: R. W. Hart
6
RTLA 897. Amazon molly. Poec ilia formosa
Material: Ten lateral hemisections
Diagnosis: Exhuberant invasive thyroid hyperplasia versus carcinoma;
visceral granulomas
Submitter: R. W. Hart
RTLA 898. Amazon molly, Poec ilia formosa
Material: Thirty-four lateral hemisections
Diagnosis: Exhuberant invasive thyroid hyperplasia versus carcinoma;
visceral granulomas
Submitter: R. W. Hart
RTLA 899. Rainbow trout, Salmo gairdneri
Material: Three pieces of tissue from a large subdermal growth lo¬
cated along the lateral line below and somewhat posterior
to the dorsal fin; 2 microscope slides
Diagnosis: Undifferentiated mesenchymal sarcoma
Submitter: C. E. Smith
RTLA 900. Rainbow trout, Salmo gairdneri
Material: One microscope slide
Diagnosis: Nephroblastoma
Submitter: Co E. Smith
RTLA 901. Rainbow trout, Salmo gairdneri
Material: Eight pieces of tissue: spleen, liver, kidney, and thymus
5 microscope slides
Diagnosis: Lymphosarcoma
Submitter: Co E. Smith
RTLA 902 o Chum salmon, Oncorhync hus keta
Material: One paraffin block
Diagnosis: Nephroblastoma
Submitter: T. Po T. Evelyn
RTLA 903. Chinook salmon, Oncorhynchus tshawytscha
Material: Almost the complete head with both pathologic and normal
tissue; 1 color photograph
Diagnosis: Probable malignant lymphoma; tissue too autolyzed for
definitive diagnosis
Submitter: G. R. Bell
RTLA 904. Sockeye salmon (Kokanee), Oncorhynchus nerka
Material: Two pieces of kidney tissue; 2 microscope slides
Diagnosis: Granulocytic leukemia versus infection
Submitter: C. E. Smith
RTLA 905A & B. Tiger salamander, Ambys toma tigrinum
Material; Two pieces of tissue; 1 color transparency
Diagnosis: 905A - Epidermal papilloma
905B - Intradermal melanophoroma
Submitter: F. L. Rose
7
RTLA 906. Tiger
Material :
Diagnos is :
Submitter:
salamander, Ambys toma tigrinum
Four pieces of tissue; 2 color transparencies
Intradermal melanophoroma
F. L. Rose
RTLA 907. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One piece of tissue; 1 color transparency
Epidermal papilloma
F. L. Rose
RTLA 908. Tiger salamander, Ambys toma tigrinum
Material: One piece of tissue; 1 color transparency
Diagnosis: Epidermal papilloma
Submitter: F. Lo Rose
RTIA 90 9 o Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
Four pieces of tissue; 1 color transparency
Polypoid dermal fibroma
F. L. Rose
RTLA 910. Tiger salamander, Ambys toma tigrinum
Material: One piece of tissue; 1 color transparency
Diagnosis: Epidermal papilloma
Submitter: F. L. Rose
RTLA 911. Tiger salamander, Ambys toma tigrinum
Material: One piece of tissue; 1 color transparency
Diagnosis: Epidermal papilloma
Submitter: Fc Lo Rose
RTLA 912. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One piece of tissue; 1 color transparency
Epidermal papilloma
Fo Lo Rose
RTLA 913. Tiger salamander, Ambys toma tigrinum
Material: One piece of tissue; 1 color transparency
Diagnosis: Epidermal papilloma
Submitter: Fo L. Rose
RTLA 914. Tiger salamander, Ambys toma tigrinum
Material: One piece of tissue; 1 color transparency
Diagnosis: Epidermal papilloma
Submitter: F. Lo Rose
RTLA 915. Tiger salamander, Ambys toma tigrinum
Material: One piece of tissue; 1 color transparency
Diagnosis: Epidermal papilloma
Submitter: F. L. Rose
RTLA 916. Tiger salamander, Ambys toma tigrinum
Material: One piece of tissue; 1 color transparency
Diagnosis: Intradermal melanophoroma
Submitter: F. L. Rose
8
RTLA 917. Largemouth bass, Mlcropterus salmoides
Material: One piece of testicular tissue; 1 black and white photograph
Diagnosis: Leiomyoma
Submitter: Ro L. Herman
RTLA 918. American smelt, Osmerus mordax
Material: Six microscope slides; 2 black and white photographs
Diagnosis: Cavernous hemangioma
Submitter: J„ W. Cornick
RTLA 919. Amphiuma means
Material: Two microscope slides
Diagnosis: Granuloma in response to some crystalline material;
possibly urates
Submitter: M. Balls
RTLA 920. Leopard frog, Rana pipiens
Material: One gross specimen
Diagnosis: Widely disseminated septate fungal infection
Submitter: R. P. Dempster
RTLA 921. Australian rock oyster, Crassostrea commercialis
Material: Two microscope slides
Diagnosis: Epidermal papilloma of mantle
Submitter: P. H. Wolf
RTLA 922. Ocean pout, Macrozoarces americanus
Material: One piece of tissue from a growth on the lip; 1 microscope
slide; 2 color transparencies
Diagnosis: Epidermal papilloma
Submitter: R„ Eo Wolke
RTLA 923. Gunner, Tautogolabrus adspersus
Material: One gross specimen with lip tumor
Diagnosis: Well-differentiated ameloblastic odontoma
Submitter: S. E. Shumway
RTLA 924. Barred sand bass, Paralabrax nebulifer
Material: One gross specimen with deformed gill rakers
Diagnosis: Developmental anomaly
Submitter: M. J. Sherwood
RTLA 925 o California tonguefish, Symphurus atricauda
Material: One gross specimen
Diagnosis: Cutaneous hamartoma
Submitter: M« Jo Sherwood
RTLA 926o Dover sole. Micros tomus pac if icus
Material: One gross specimen with multiple growths predominantly on
the eyed side
Diagnosis: Epidermal papilloma
Submitter: M. J. Sherwood
9
RTLA 927. Salt water crocodile, Crocodylus porosus
Material: Four pieces of liver tissue
Diagnosis: Severe fatty metamorphosis of the liver
Submitter: J. C. Harshbarger and Mo Landolt
RTLA 928. Rainbow trout (Steelhead), Salmo gairdneri
Material: A piece of body wall with a gelatin-like growth between
the skin and underlying muscle
Diagnosis: Fibrosarcoma
Submitter: G. R. Bell
RTLA 929. Walleye, Stizostedion vitreum vitreum
Material: Two nodules in skin
Diagnosis: Fibromas with foci of ossification associated with lympho-
cystis which occurred elsewhere in the same fish
Submitter: E. Enamait
RTLA 930. Oyster, Ostrea lurida
Material: Four microscope slides
Diagnosis: Diffuse mesenchymal sarcoma
Submitter: M. C. Mix
RTLA 931. Rainbow trout (Steelhead), Salmo gairdneri
Material: One microscope slide from a gill tumor
Diagnosis: Neoplasm of bipotential gill epithelium, manifest in some
areas as an ameloblastoma and in other areas as a gill
arch epithelioma
Submitter: H. Wolf
RTLA 932. Rainbow trout, Salmo gairdneri
Material: Fourteen microscope slides; 1 color photograph
Diagnosis: Chloroma
Submitter: H. Wolf
RTLA 933 . Drosophila melanogas ter
Material: Two microscope slides
Diagnosis: Prohemocytic leukemia
Submitter: E. A. F. Gateff
RTLA 934. Carp.
Material :
Diagnos is :
Submitter :
Cyprinus carpio
Seventy-four microscope slides
Sertoli cell tumor
R. Sonstegard
RTLA 935. "Ishimochi, ” Argyrosomus argentatus
Material: Nine black and white photographs; 3 paraffin blocks;
six microscope slides
Diagnosis: Melanoma
Submitter: 1. Kimura
Reprint: Kimura, Ikuo e_t £l. Melanoma on the skin in a teleost
fish, Argyrosomus argentatus. Abstracts: Xlth Inter¬
national Cancer Congress, Florence, Italy, 20-26 October
1974, 2: 174-175. 1974.
10
RTLA 936. Firebellied newt, CynoT:)S pyrrho^aster
Material: One microscope slide
Diagnosis: Epidermal papilloma
Submitter: Sc V. Bryant
Reprint: Bryant, Susan Vc Spontaneous Epidermal Tumor in an Adult
Newt, Cynops pyrrhogas ter . Cancer Res., 623-625. 1973,
RTLA 937. Northern pike, Esox luc Lus
Material: Two gross specimens irradiated with 400 R, one of which
was also covered with cutaneous black spots, plus an un¬
treated control
Diagnosis: Black spot disease (granulomas) due to encysted metacer-
caria presumably of Neodiplos timum cuticola . Blood pic¬
ture from irradiated fish in normal range.
Submitter: E. R. Brown
RTLA 938. Northern spiky dogfish, Squalus b la invilli
Material: Large growth with metastases and some surrounding normal
liver; 3 color transparencies
Diagnosis: Probable neurilemmoma (Schwannoma)
Submitter: Pe M. Hine
RTLA 939. Snapper, Chrysophrys auratus
Material: Portion of backbone with a large ovoid growth deriving
from the area of the backbone
Diagnosis: Mycotic granuloma
Submitter: P. M. Hine
RTLA 940. Chinook salmon, Oncorhynchtis tshawytscha
Material: A large ovarian mass (solid growth adjacent to the
ovary) and roe
Diagnosis: Normal testis; fish is bisexual
Submitter: J. G. Hnath
RTLA 941. Butterfly fish
Material: One gross specimen with black growth involving second
and third dorsal spines
Diagnosis: Benign melanoma arising from dermal melanophores
Submitter: A. C. Smith
RTLA 942. Rainbow trout (Steelhead), Salmo gairdneri
Material: A growth and muscle from abdominal wall
Diagnosis: Neurofibroma (Schwannoma)
Submitter: G. R. Bell
RTLA 943. Armored catfish, Corydoras sp.
Material: Three microscope slides of the spinal cord
Diagnosis: Parasitized by Myxosporida (Myxobolus sp.)
Submitter: G. E. Cosgrove
RTLA 944. Tiger salamander, Ambys toma tigrinum
Material: One gross specimen with 4 skin lesions
Diagnosis: 1, 3, & 4 - Epidermal papilloma; 2 - normal variation
Submitter: F. L. Rose
11
RTLA
RTIA
RTLA
RTLA
RTLA
RTLA
RTLA
RTLA
RTLA
RTLA
945. Tiger
Material :
Diagnosis :
Submitter :
salamander, Amby stoma tigrinum
One gross specimen with 3 skin lesions
1 - Early intradermal melanocytoma ; 2 - epideirmal
papilloma; 3 - epidermal hyperplasia
F, L. Rose
946. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 4 skin lesions
1, 2, & 4 - Epidermal papilloma; 3 - epidermal
inclusions cysts
F. L, Rose
947. Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with distended abdomen
Paraovarian serous cyst
F. L. Rose
948. Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 2 skin lesions
1 - Epidermal papilloma; 2 - intradermal melanocytoma
F. L. Rose
949. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 4 skin lesions
1 & 3 - Intradermal melanocytoma; 2 & 4 - outer (papillary)
layer of dermis is absent
F. Lc Rose
950„ Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 5 skin lesions
1, 3 & 4 - Intradermal melanocytoma; 2 - epidermal
melanocytoma; 5 - invasive dermal melanocytoma
F. Lo Rose
951. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with multiple skin lesions
Epidermal hyperplasia
F. Lo Rose
952. Tiger salamander, Ambys toma tigrinum
Material: One gross specimen with a skin lesion
Diagnosis: Epidermal papilloma
Submitter: F„ L. Rose
953. Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with a skin
Intradermal melanocytoma
F. L. Rose
lesion
954. Tiger salamander, Ambys toma tigrinum
Material: One gross specimen with a skin lesion
Diagnosis: Invasive dermal melanocytoma
Submitter: F. L. Rose
12
RTLA
955. Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen
Ectopic lung
F. L. Rose
RTLA 956. Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with a skin
Intraderma 1 melanocytoma
F. Lo Rose
lesion
RTLA 957. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 3 skin
1 - Exceptionally thin dermis;
3 invasive dermal melanocytoma
F. L„ Rose
les ions
2 - indeterminable;
RTLA 958 o Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 4 skin lesions
1 - Thin dermis; 2 - epidermal papilloma;
melanocytoma; 4 - intradeirmal fibroma
Fo L. Rose
3
intraderma 1
RTLA
959. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with cyst on gill
Hematoma
F„ Lo Rose
RTLA
960. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with skin lesions
Polycystic epidermal papilloma; epidermal papilloma;
epidermal inclusion cysts
F. L. Rose
RTLA
961c Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with multiple skin lesions
Epidermal inclusion cysts
Fo Lo Rose
RTLA 962. Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with a skin lesion
Intraderma 1 melanocytoma
F. Lo Rose
RTLA
963. Tiger
Material :
Diagnos is :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with a skin lesion
Intradermal melanocytoma
F. L. Rose
RTLA 964. Tiger
Material ;
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with small white spot on tail
Indeterminable due to postmortem sloughing of epidermis
Fo Lo Rose
13
RTLA 965. Tiger
Material :
Diagnosis :
Submitter :
salamander, Amby stoma tigrinum
One gross specimen with papillary skin lesions
Indeterminable due to postmortem sloughing of epidermis
Fo L. Rose
RTLA 966. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with a skin
Early intradermal melanocytoma
F. L. Rose
lesion
RTLA 967. Tiger
Material ;
Diagnosis :
Submitter:
salamander, Ambys toma tigrinum
One gross specimen with a skin
Early intradermal melanocytoma
Fo Lo Rose
lesion
RTLA 968. Tiger salamander, Ambys toma tigrinum
Material: One gross specimen with a skin lesion
Diagnosis: Invasive dermal melanocytoma
Submitter: F. L. Rose
RTLA 969. Tiger salamander, Ambys toma tigrinum
Material: One gross specimen with a skin lesion
Diagnosis: Invasive dermal melanocytoma
Submitter: F. L. Rose
RTLA 970o Red-footed tortoise, Geochelone carbonaria
Material: Two microscope slides
Diagnosis: Parathyroid adenoma
Submitter: F„ L. Frye
RTLA 971 o Brown bullhead, Ictalurus nebulosus
Material: One microscope slide
Diagnosis: Epidermal hyperplasia versus epidermal papilloma
Submitter: J. L„ Gaines, Jr.
RTLA 972o Angelfish, Pterophyllum scalare
Material: One gross specimen; 2 black and white photographs
Diagnosis: Fibropapillomatous polyps engulfing normal tooth
buds (germs) and associated with underlying new
bone formation
Submitter: P. M. Hine
RTLA 973. Sea hare, Aplysia californica
Material: Two opaline glands -- one pathologic and one normal
Diagnosis: Mycotic granuloma
Submitter: D„ 0. Carpenter
Reprint: [Classic article] Eales, N. B. Transactions of the
Liverpool Biological Society, Vol. 35, pp. 183-266. 1921.
RTLA 974. Rainbow trout, Salmo gairdneri
Material: One microscope slide of gill tumor
Diagnosis: Basal cell papilloma versus ameloblastic epithelioma
Submitter: R„ J. Roberts
14
RTLA 975. Western fence lizard, Sceloporus occidentalis
Material: One microscope slide (liver, kidney and heart tissue)
Diagnosis: Lower nephron nephrosis
Submitter: Fo L. Frye
RTLA 976. Rainbow trout, Salmo gairdneri
Material: One piece of tissue; 2 microscope slides
Diagnosis: Leiomyoma
Submitter: J. van de Kerkhoff
RTLA 977. Hawksbill sea turtle, Eretmochelys imbricata
Material: A growth removed from the left fore flipper
Diagnosis: Bacterial granuloma
Submitter: D. Allen and R. Lloyd
RTLA 978. Starfish, Asterina sp.
Material: Part of D ray with a raised growth
Diagnosis: Developmental anomaly
Submitter: F. C. Hotchkiss
RTLA 979. Atlantic sturgeon, Ac ipenser oxyrhynchus
Material: One microscope slide
Diagnosis: Parafollicular serous cyst adjacent to a smaller
perifollicular pseudocyst
Submitter: J. A. Quick, Jr. and J. A. Huff
RTLA 980 o Atlantic sturgeon, Ac ipenser oxyrhync hus
Material: One microscope slide
Diagnosis: Perifollicular pseudocyst
Submitter: J„ A„ Quick, Jr. and J. A. Huff
RTLA 981. Oyster, Ostrea lurida
Material: Six microscope slides
Diagnosis: Hematopoietic neoplasm
Submitter: M. C. Mix
RTLA 982. Cave isopod, Speoc irolana bolivari
Material: Three gross specimens with sac-like growths
protruding between the 4th and 5th walking legs
Diagnosis: Possible distended abdomens of an ectoparasite
Submitter: T. E„ Bowman
RTLA 983. Australian rock oyster. Grasses trea commercial is
Material: Four microscope slides
Diagnosis: Hematopoietic neoplasm
Submitter: P. H. Wolf
RTLA 984. Red rattlesnake, Cro talus ruber
Material: A portion of a large paralyzing mass located on the dorsum,
dorsal and lateral to the spinal column
Diagnosis: Undifferentiated sarcoma
Submitter: E. Ao Holzinger
15
RTIA
RTIA
RTLA
RTLA
RTLA
RTLA
RTLA
RTLA
RTLA
RTLA
RTLA
985. American crocodile, Crocodylus acutus
Material: Two microscope slides; 2 paraffin blocks
Diagnosis: Parasitized by Capillaria recurva
Submitter: E. Elkan
986. Eastern garter snake, Thamnophis sirtalis
Material: Two microscope slides
Diagnosis: Parasitized by Ophiotaenia perspicua
Submitter: E. Elkan
987. Emerald tree snake, Ahaetulla pras ina
Material: Four microscope slides; 1 paraffin block
Diagnosis: Parasitized by Sphaerechinorhynchus (?) serpenticola
Submitter: Eo Elkan
988. Atlantic salmon, Salmo salar
Material: Two tissue blocks
Diagnosis: Marked thyroid hyperplasia
Submitter: J. G. Hnath
989. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with cyst-like growth on head
Subdermal serous cyst
F. L. Rose
990. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with a skin
Dermal fibroma
F, L. Rose
lesion
991. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with a skin
Dermal fibrosarcoma
F. L. Rose
lesion
992. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 2 skin
Epidermal papilloma
F. L. Rose
lesions
993. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 4 skin
1 6c 3 - Epidermal papilloma; 2
melanocytoma
F. L. Rose
lesions
- pending;
4
intraderma 1
994. Tiger
Material :
Diagnosis :
Submitter :
salamander, Ambys toma tigrinum
One gross specimen with 2 skin lesions
1 - Intradermal fibroma; 2 - epidemal papilloma
F. L. Rose
995. Tiger salamander, Ambys toma tigrinum
Material: One gross specimen with 2 cyst-like growths on head
Diagnosis: 1 6c 2 - Serous cysts
Submitter: F. L. Rose
16
RTIA
996. Tiger
Material ;
Diagnosis :
Submitter :
salamander, Ambystoma tigrinum
One gross specimen with 4 skin lesions
1 - Subdermal serous cyst; 2 - hyperplastic stratum papillosum
of dermis; 3 intradermal fibroma; 4 - intraderma 1 melanophoroma
F, L. Rose
RTIA
997, Tiger
Material :
Diagnosis ;
Submitter :
salamander, Ambystoma tigrinum
One gross specimen with a skin lesion
Probable epidermal papilloma
F. Lo Rose
RTIA
998. Tiger
Material t
Diagnosis i
Submitter i
salamander, Ambystoma tigrinum
One gross specimen with cyst-like growth
Subdermal serous cyst
Fo L. Rose
RTIA 999. Tiger
Material ;
Diagnosis :
Submitter :
salamander, Ambystoma tigrinum
One gross specimen with a skin lesion
Dermal myxosarcoma
F, L. Rose
RTIA 1000. Sea bream, Sparus auratus
Material; One microscope slide; 1 black and white photograph
Diagnosis: Oral papillomatosis involving odontogenic epithelium and
associated with marked proliferation of odontoblastic tissue
Submitter: !<, Paperna
RTIA 1001. Smallmouth bass, Micropterus dolomieui
Material: One microscope slide; 2 color transparencies
Diagnosis: Scarring probably due to an infection or to a physical or
chemical injury
Submitter: H, Rothenbacher
RTIA 100 2 o Chinook salmon, Oncorhynchus tshawytscha
Material: An anal fin and surrounding musculature bearing a growth
Diagnosis; Mesenchymal neoplasm; cell type indeterminable due to poorly
preserved tissue
Submitter: P. M, Hine
RTIA 1003. Rainbow trout, Salmo gairdneri
Material: One microscope slide; 1 paraffin block; 14 color transparencies
Diagnosis: Nephroblastoma
Submitter: H, Wolf
RTIA 1004. Clam,
Material :
Diagnosis :
Submitter ;
Reprint :
Macoma balthica
Two microscope slides
Highly invasive carcinoma of gill epithelium
F o G . Ke m
Christensen, Darryl J., C. Austin Farley, and Frederick G. Kern.
Epizootic Neoplasms in the Clam Macoma balthica (L.) From
Chesapeake Bay. J. Natl. Cancer Inst., ^(6): 1739-1749. 1974.
17
RTLA 1005. Hard-shell clam (Quahog), Mercenaria mercenaria
Material: Three microscope slides; 1 paraffin block
Diagnosis: Chlamydia infection in digestive diverticula
Submitter: S. V. Otto
RTIA 100b. Hard-shell clam (Quahog), Mercenaria mercenaria
Material: One microscope slide; 1 paraffin block
Diagnosis: Chlamydia infection in digestive diverticula
Submitter: S. V. Otto
RTLA 1007. Hard-shell clam (Quahog), Mercenaria mercenaria
Material: One microscope slide
Diagnosis: Gill inclusion disease
Submitter: S. Vo Otto
RTLA 1008A & B.
Material :
Diagnosis :
Submitter :
Clam, Anodonta corpulent!
Six clam hemisections -- 1 pathologic and 5 normal
Hematopoietic response to bacterial infection
Go E. Cosgrove
RTLA 1009A & B.
Material :
Diagnosis :
Submitter :
Eastern box turtle, Terrapene Carolina
A. Apical half of enlarged, dense, white right lung
B. Apical half of normal left lung
Hyperplastic inflammatory or acute hypersensitivity reaction
Go Eo Cosgrove
RTLA 1010. Pacific tree frog, Hyla regilla
Material: One microscope slide; 2 color transparencies
Diagnosis: Chondomyxoma
Submitter: F. L. Frye
RTLA 1011. Lake trout, Salvelinus namaycush
Material: One microscope slide; a portion of growth found in the mouth,
upper jaw area
Diagnosis: Ossifying myxofibroma
Submitter: T. P., T. Evelyn
RTLA 1012o Northern pike, Esox luc ius
Material: One microscope slide; a portion of a growth on top of the skull
Diagnosis: Malignant melanoma
Submitter: To P. To Evelyn
RTLA 1013o Winter flounder, Pseudopleuronectes americanus
Material: One fish head with a smooth, spherical fluid-filled cyst
emerging from the left eye socket and displacing the eye
Diagnosis: Serous cyst
Submitter: B. B, Collette and K. W. Collette
RTLA 1014. Benthocomes tes robustus
Material: Four gross specimens; one with growth above operculum --
3 normal
Diagnosis: Protozoan cyst
Submitter: Ro Schoknecht
18
RTLA 1015. Ocean pout, Macrozoarces americanus
Material: Liver, heart, complete alimentary tract, gall bladder,
testes with growth, and spleen
Diagnosis: Adenocarcinoma of the spermatic duct
Submitter: Bo Bo Collette
RTLA 1016, Pacific garter snake, Thamnophis sirtalis
Material: One microscope slide
Diagnosis: Malignant chromophoroma
Submitter: F, L. Frye
RTLA 1017 o Root-knot nematode, Meloidogyne incognita
Material: Four black and white photographs showing caudal enlargements
Diagnosis: Teratoid anomalies
Submitter: R. M. Sayre
Reprint: Sayre, Richard M, Observations on Aberrant Root-Knot
Nematode Larvae. Program & Abstracts of the Joint Meeting
XIII Society of Nematologists VII Organization of Tropical
American Nematologists, 18-23 August 1974, Riverside,
California, p. 24, 1974.
RTLA 1018. Sea peach, Halocynthia pyriformis
Material: Tunic lesion near siphon
Diagnosis: Injury and repair of tunic epithelium
Submitter: R. S. Anderson
RTLA 1019. Sea peach, Halocynthia pyriformis
Material: One gross specimen with lesion near siphon
Diagnosis: Injury and repair of tunic epithelium
Submitter: R. S. Anderson
RTLA 1020. Sea
Material :
Diagnosis :
Submitter :
peach, Halocynthia pyriformis
One gross specimen with teardrop-shaped extension below siphon
Probable infectious lesion of tunic
R. A. Anderson
RTLA 1021. Amazon molly, Poec ilia formosa
Material: Four microscope slides
Diagnosis: Marked thyroid hyperplasia versus thyroid carcinoma
Submitter: G. E. Cosgrove
RTLA 1022, Chinook salmon, Oncorhync hus tschawytscha
Material: Three microscope slides
Diagnosis: Acute granulocytic leukemia
Submitter: W. T. Yasutake
RTLA 1023. Chinook salmon, Oncorhync hus tschawytscha
Material: Three microscope slides
Diagnosis: Acute granulocytic leukemia
Submitter: W. T, Yasutake
RTLA 1024. Tuxedo swordtail, Xiphophorus helleri
Material: Nine black and white photographs; 4 color transparencies;
3 microscope slides
Diagnosis: Melanoma
Submitter: T, Ishikawa
19
RTLA. 1025, Rockfish ("red snapper"), Sebastes sp.
Material: A large, soft mass of tissue on the lower jaw
Diagnosis: Dermal f ibropapilloma
Submitter: G. R, Bell
RTLA 1026. Lake trout, Salvelinus namaycush
Material: A growth protruding from the body wall
Diagnosis: Epidermal papilloma
Submitter: G. E. Hoskins
RTLA 1027. Goldfish, Carassius auratus
Material: One specimen with greatly distended abdomen
Diagnosis: Multiloculated serous cyst of either mesenteric or
ovarian origin
Submitter: W, G. Banfield
RTLA 1028, Guppy, Poecilia reticulata
Material: Two microscope slides
Diagnosis: Marked thyroid hyperplasia (thyroid toxin type) coesixtent
with visceral granulomas caused by acid-fast organisms
Submitter: S, Cohen
RTLA 1029. Oyster, Ostrea lurida
Material: Two microscope slides
Diagnosis: Hematopoietic neoplasm
Submitter: M. C. Mix
RTLA 1030. African toad, Bufo sp.
Material: Five microscope slides
Diagnosis: Hematopoietic neoplasm
Submitter: R. L. Snyder
RTLA 1031. Northern pike, Esox luc ius
Material: Ten microscope slides
Diagnosis: Lymphoma
Submitter: 0. Ljungberg
Reprint: Winqvist, G,, 0, Ljungberg, and Birgitta Ivarsson. Electron
Microscopy of Sarcoma of the Northern Pike (Esox luc ius L),
In: Unifying Concepts of Leukemia, Bibl. haeraat. No. 39,
Ro M» Dutcher and L. Chieco-Bianchi (ed.), pp. 26-30,
Karger, Basel, 1973.
RTLA 1032. Northern pike, Esox luc ius
Material: Three microscope slides
Diagnosis: Lymphoma
Submitter: 0. Ljungberg
Reprint: [See RTLA 1031]
RTLA 1033. Northern pike, Esox luc ius
Material: Nine microscope slides
Diagnosis: Lymphoma
Submitter: 0. Ljungberg
Reprint: [See RTLA 1031]
20
RTLA 1034. Northern pike, Esox luc ius
Material; One microscope slide
Diagnosis; Lymphoma
Submitter; 0. Ljungberg
Reprint; [See RTLA 1031]
RTLA 1035. Northern pike, Esox luc ius
Material; One color photograph of gross specimen
Diagnosis; Lymphoma
Submitter; 0. Ljungberg
Reprint; [See RTLA 1031]
RTLA 1036. European eel, Anguilla anguilla
Material; Five pieces of tissue
Diagnosis; A diffusely infiltrating, highly undifferentiated gastric
neoplasm
Submitter; P. Ghittino
RTLA 1037. Iguana iguana
Material; One microscope slide
Diagnosis; Hydronephrosis
Submitter; F. L. Frye
RTLA 1038. Coho salmon, Oncorhynchus kisutch
Material; Two pieces of tumor; 1 color photograph
Diagnosis; Neoplasm of mesenchymal tissue, but cell type indeterminable
due to freezing artifacts
Submitter; G. E. Hoskins
RTLA 1039. Chinook salmon, Oncorhynchus tshawytscha
Material; One fish head including a piece of the right side which had
been removed to show the growth
Diagnosis; Hematopoietic neoplasm (probable thymic lymphoma)
Submitter; G. E. Hoskins
RTLA 1040. Chinook salmon, Oncorhynchus tshawytscha
Material; Tumor with piece of gill attached
Diagnosis; Neoplasm of mesenchymal tissue, but cell type indeterminable
due to freezing artifacts
Submitter: G. E. Hoskins
RTLA 1041. Snapper, Chrysophrys auratus
Material; One block of kidney tissue
Diagnosis; Granuloma
Submitter: P. M. Hine
RTLA 1042. Snapper, Chrysophrys auratus
Material; One block of kidney tissue; 2 microscope slides
Diagnosis: Granuloma
Submitter: P. M. Hine
RTLA 1043. Rainbow trout, Salmo gairdneri
Material: One block of kidney tissue; 4 microscope slides; 1 black and
white photograph
Diagnosis; Malignant lymphoma
Submitter; P. M. Hine
21
RTLA 1044. Brown trout, Salmo tmtta
Material: Large growth with attached stomach; 4 microscope slides;
3 black and white photographs
Diagnosis: Leiomyoma
Submitter: P. M. Hine
RTIA
1045. Coho
Material :
Diagnosis :
Submitter :
salmon, Oncorhynchus kisutch
Three pieces of tissue with lesions on the skin
Abscess of scale pockets; etiology undetermined
Jo Go Hnath
RTLA 104b. Lake trout, Salvelinus namaycush
Material: Tissue from a kidney tumor and from a tumor on gill arches
Diagnosis: Malignant well-differentiated lymphocytic lymphoma
Submitter: Jo Go Hnath
RTLA 1047. Yellow bullhead, Ictalurus natalis
Material: One gross specimen with black spots and raised areas
on the head
Diagnosis: Epidermal hyperplasia
Submitter: J, A. Couch and Bream Fishermen Association
RTLA 1048. Yellow bullhead, Ictalurus natalis
Material: One gross specimen with black spots and raised areas
on the head
Diagnosis: Incipient epidermal papillomas
Submitter: Jo Ao Couch and Bream Fishermen Association
RTLA 1049. Yellow bullhead, Ictalurus natalis
Material: One gross specimen with black spots and raised areas
on the head
Diagnosis: Epidermal hyperplasia
Submitter: J. A. Couch and Bream Fishermen Association
RTLA 1050. Indian monitor lizard, Varanus bengalensis
Material: Two microscope slides
Diagnosis: Metaplastic bile ducts probably due to toxicosis
Submitter: Fo L. Frye
RTLA 1051. Hybrid frog, Rana pa lus tris x pipiens
Material: One microscope slide
Diagnosis: Renal adenocarcinoma; induced by 5090 x G fraction
of Luck^ tumor
Submitter: Do J. Mulcare
Reprint: Mulcare, Donald Jo Non-Specific Transmission of the Luckd
Tumor. In: Biology of Amphibian Tumors, M. Mizell (ed.),
ppo 240-253, Springer-Verlag , New York, 1969o
RTLA 105 2 o Leopard frog, Rana pipiens
Material: One microscope slide of blister on kidney
Diagnosis: Invasive tumor vesicle induced by virus rich 5090 x G
fraction of Luck^ tumor
Submitter: D. Jo Mulcare
Reprint: [See RTLA 1051]
22 -
RTLA 1053. Hybrid frog, Rana pipiens x pa lustris
Material: One microscope slide of blister on kidney
Diagnosis: Non-invasive kidney vesicle induced by virus rich 5090 x G
fraction of Luckd tumor
Submitter: D, J. Mulcare
Reprint: [See RTLA 1051]
RTLA 1054. Pickerel frog, Rana pa lustris
Material: One microscope slide
Diagnosis: Involuted tumor vesicle induced by injecting an embryo with
a 5090 X G fraction of Luckd tumor
Submitter: D. J. Mulcare
Reprint: [See RTLA 1051]
RTLA 1055. Pickerel frog, Rana pa lustris
Material: One microscope slide
Diagnosis: Adenocarcinoma of mesonephros induced by 5090 x G fraction
of Luck^ tumor
Submitter: D, J, Mulcare
Reprint: [See RTLA 1051]
RTLA 1056. Hybrid frog, Rana pipiens x pa lustris
Material: One microscope slide
Diagnosis: Solid renal adenocarcinoma induced by 5090 x G fraction
of Luckd tumor
Submitter: D. J. Mulcare
Reprint: [See RTLA 1051]
RTLA 1057A & B.
Material :
Diagnosis :
SuDmitter :
Reprint :
Pickerel frog, Rana pa lustris
Two microscope slides of 2 kidney lobes
Renal adenocarcinoma induced in the adult by an implant of
Luckd tumor into dorsal lymph space
D. Jc Mulcare
[See RTLA 1051]
RTLA 1058 o Green frog, Rana clamitans
Material: One microscope slide
Diagnosis: Mesonephric adenocarcinoma induced by a 5090 x G fraction
of Luckd tumor injected into the embryo
Submitter: D. J. Mulcare
Reprint: [See RTLA 1051]
RTLA 1059. Sea bream, Sparus auratus
Material: One gross specimen with lip tumor
Diagnosis: Ameloblastic fibro-odontoma
Submitter: I. Paperna
RTLA 1060. Sea bream, Sparus auratus
Material: One gross specimen with lip tumor
Diagnosis: Ameloblastic fibro-odontoma
Submitter: I. Paperna
RTLA 1061. Sea
Material :
Diagnosis :
Submitter:
bream, Sparus auratus
Segment of fish head with lip tumor
Ameloblastic fibro-odontoma
I. Paperna
23
RTLA 1062A, B, & C. Oyster, Ostrea lurida
Material: Tissue samples of gill, mantle, and digestive gland
Diagnosis: Normal
Submitter: M. C. Mix
RTLA 10b3. Walleye, Stizostedion vitreum vitreum
Material: Head with large growth posterior to the left eye
Diagnosis: Ossifying fibroma
Submitter: W, J<, Buc
RTLA. 10b4. Colorado River toad, Bufo alvarius
Material: Three pieces of tissue: liver, kidney, and possibly spleen
Diagnosis: Mycotic granuloma
Submitter: Go C, Blasiola, Jro
RTLA 10b5. Hard-shell clam, Mercenaria mere enaria
Material: Fixed digestive diverticula tissue
Diagnosis: Chlamydia infection
Submitter: J. C. Harshbarger, S. C. Chang, and S. V. Otto
RTLA 1066, Hard-shell clam, Mercenaria mere enaria
Material: Fixed digestive diverticular tissue
Diagnosis: Chlamydia infection
Submitter: J, C, Harshbarger, S. C. Chang, and S. V, Otto
RTLA 1067. Hard-shell clam, Mercenaria mercenaria
Material: Fixed digestive diverticula tissue
Diagnosis: Chlamydia infection
Submitter: J. C, Harshbarger, S, C. Chang, and S, V. Otto
RTLA lObSo Hard-shell clam, Mercenaria mere enaria
Material: Fixed digestive diverticula tissue
Diagnosis: Chlamydia infection
Submitter: J, C, Harshbarger, S, C, Chang, and S, V. Otto
RTLA 1069. Ruin lizard, Lacerta sicula
Material: Six microscope slides
Diagnosis: Fibrosarcoma
Submitter: E. Elkan
RTLA 1070o Trevally (jack?), Caranx lutescens
Material: Tissue around vent; 3 black and white photographs
Diagnosis: Neurofibrosarcoma
Submitter: P. M. Hine
RTLA 1071. Pacific cod, Gadus macrocepha lus
Material: One fish head with a tumorous growth on the inside
of the gill covers
Diagnosis: Parabranchial adenoma
Submitter: C, R„ Forrester
RTLA 1072. Pacific cod, Gadus macrocepha lus
Material: One fish head with a tumorous growth on the inside
of the gill covers
Diagnosis: Parabranchial adenoma
Submitter: C. R. Forrester
24
RTLA 1073* Pacific cod, Gadus macrocephalus
Material: One fish head with a tumorous growth on the inside
of the gill covers
Diagnosis: Parabranchial adenoma
Submitter: C, R* Forrester
RTLA 1074. Pacific cod, Gadus macrocepha lus
Material: One fish head with a tumorous growth on the inside
of the gill covers
Diagnosis; Parabranchial adenoma
Submitter: C. R. Forrester
RTIA 1075. Pacific cod, Gadus macrocephalus
Material: One fish head with a tumorous growth on the inside
of the gill covers
Diagnosis: Parabranchial adenoma
Submitter: C, R, Forrester
RTIA 107b, Pacific cod, Gadus macrocephalus
Material: One fish head with a tumorous growth on the inside
of the gill covers
Diagnosis: Parabranchial adenoma
Submitter: C. R. Forrester
RTIA 1077. Pacific cod, Gadus macrocephalus
Material: One fish head with a tumorous growth on the inside
of the gill covers
Diagnosis; Parabranchial adenoma
Submitter: C. R. Forrester
25
INDEX OF NEOPLASM - ANIMAL GROUP - AND RTLA NUMBER
Adenocarcinoma: Amphibian - 1051-8; Fish - 1015
Ameloblastoma: Fish - 931, 974, 1059-61
Basal cell papilloma: Fish - 974
Carcinoma: Mo Husk - 1004
Chloroma: Fish - 932
Chondomyxoma : Amphibian - 1010
Chromophoroma : Reptile - 1016
Epidermal papilloma: Amphibian - 905, 907-15, 935, 944-6, 948, 952, 958, 960,
992-4, 997; Fish - 922, 971-2, 999, 1026, 1048; Mollusk - 921
Epithelioma: Fish - 931
Fibroma: Amphibian - 990, 994, 958, 996; Fish - 929, 1025, 1063
Fibrosarcoma: Reptile - 1069; Amphibian - 991; Fish - 928, 1036
Hamartoma: Fish - 925
Hemangioma: Fish - 918
Leiomyoma: Fish - 917, 976, 1044
Lymphoma /Lymphos a rc oma : Amphibian - 1030; Fish - 901, 903-4, 1022-3, 1031-5,
1039-40, 1046; Mollusk - 981, 983, 1029; Arthropod - 933
Malignant melanoma: Amphibian - 954, 957, 968-9; Fish - 1012
Melanophoroma : Amphibian - 905-6, 916, 945, 948-50, 953, 956, 958, 962-3,
966-7, 993, 996; Fish - 935, 941, 1024
Myxosarcoma: Amphibian - 999
Nephroblastoma: Fish - 900, 902, 1003
Neurofibroma /Neurilemmoma : Shark - 938; Fish - 942
Neurofibrosarcoma: Fish - 1070
Odontoma: Fish - 923, 1000, 1059-61
Ossifying myxofibroma: Fish - 1011
Parabranchial adenoma: Fish - 1071-7
Parathyroid adenoma: Reptile 970
26
Sarcoma; Reptile - 984; Fish - 899, 1002, 1038, 1040; Mollusk - 930
Sertoli cell tumor: Fish ^ 934
Thyroid hyperplasia and/or carcinoma: Fish - 893-8, 988, 1021, 1028
27
PHYLUM CHORDATA
PHYLOGENETIC INDEX o i r ,; .jv/l
Class Reptilia ' ■ ■ ■
Order Chelonia (turtles) - RTLA 970, 977, 1009
Order Squama ta (lizards, snakes) - RTLA 975, 984, 986-7, 1016, 1037,
1050, 1069
Order Loricata (alligators, crocodiles) - RTLA 927, 985
Class Amphibia
Order Caudata (salamanders) - RTLA 905-16, 919, 936, 944-69, 989-99
Order Anura (toads, frogs) - RTLA 920, 1010, 1030, 1051-8, 1064
Class Osteichthyes
Order Salmoniformes
Family Salmonidae (salmon, trout, whitefish) - RTLA 899-904, 928,
931-2, 940, 942, 974, 976, 988, 1002-3, 1011, 1022-3, 1026, 1038-40,
1043-6
Family Esocidae (pike, pickerel) - RTLA 937, 1012, 1031-5
Family Osmeridae (smelts) - RTLA 918
Order Perc if ormes
Family Serranidae (sea basses) - RTLA 924
Family Centrarchidae (sunf ishes , . bass ) - RTLA 917, 1001
Family Percidae (perches) - RTLA 929, 1063
Family Carangidae (jacks, pompanos) - RTLA 1070
Family Sparidae (porgies) - RTLA 1000, 1059-61
Family Sc iaenidae (drums) - RTLA 888-92
Family Labridae (wrasses) - RTLA 923
Family Lut janidae (snappers) - RTLA 939, 1041-2
Family Scorpaenidae (scorpionf ish, rockfish) - RTLA 1025
Family Chaetodontidae (butterfly fishes) - RTLA 941, 972
28
Order Cypriniformes (suckers, roaches, goldfish) - RTLA 934, 1027
Order Siluriformes (catfish) - RTLA 943, 971, 1047-9
Order Ophidioidae - RTLA 1014
Order Pleuronectiformes (sole) - RTLA 925-6, 1013
Order Atheriniformes (killifish, platys, needlefish, mollies, top
minnows) - RTLA 893-8, 1021, 1024, 1028
Order Gad iformes (cod) - RTLA 922, 1015, 1071-7
Order Angui Hi formes (eels) - RTLA 1036
Order Ac ipenser iformes (sturgeons) - RTLA 979-80
Not c lass if ied - RTLA 935
Class Chondrichthyes
Order Squaliformes (sharks) - RTLA 938
SUB PHYLUM TUNICATA
RTLA 1018-20
PHYLUM ECHINODERMATA
Class Asteroidea (starfish) - RTLA 978
PHYLUM MOLLUSCA
Class Gastropoda
Subc lass Pulmonata (snails) - RTLA 973
Class Bivalvia (mussels, clams, scallops, oysters) - RTLA 921, 930, 981,
983, 1004-8, 1029, 1062, 1065-8
PHYLUM ARTHROPODA
Class Insec ta
Order Diptera (flies) - RTLA 933
Class Crustacea
Order Isopoda - RTLA 982
29
PHYLUM NEMATODA
Class Secernentea
Order Tylenchida - RTLA 1017
30 -
INDEX OF SPECIMENS BY SCIENTIFIC AND COMMON NAMES
RTLA NO.
A
Acipenser oxyrhynchus
African toad
Ahaetulla prasina
Amazon molly
Ambystoma ti^rinum
American crocodile
American smelt
Amphiuma means
Angelfish
Anguilla anguilla
Anodonta corpulent!
Aplysia californica
Argyrosomus argentatus
Armored catfish
Asterina sp.
Atlantic salmon
Atlantic strugeon
Australian rock oyster
B
Barred sand bass
Benthocomestes robustus
Brown bullhead
Brown trout
Bufo sp.
Bufo alvarius
Butterfly fish
C
California tonguefish
Caranx lutescens
Carassius auratus
Carp
Cave isopod
Chinook salmon
Chrysophrys auratus
Chum salmon
Coho salmon
Colorado River toad
Corydoras sp.
Crassostrea commerc ialis
Crocodylus acutus
Crocodylus porosus
979, 980
1030
987
893-898, 1021
905-916, 944-969, 989-999
985
918
919
972
1036
1008A & B
973
935
943
978
988
979, 980
921, 983
924
1014
971
1044
1030
1064
941
925
1070
1027
934
982
903, 940, 1002, 1022, 1023,
1039, 1040
949, 1041, 1042
902
1038, 1045
1064
943
921, 983
985
927
- 31
RTLA NO.
Cro talus ruber 984
Gunner 923
Cynops pyrrhogaster 936
Cyprinus carpio 934
D
Dover sole 926
Drosophila melanogaster 933
E
Eastern box turtle
Eastern garter snake
Emerald tree snake
Eretmochelys imbricata
Esox luc ius
European eel
1009A & B
986
987
977
937, 1012,
1036
1031-1035
Firebellied newt
936
G
Gadus macrocepha lus
Geochelone carbonaria
Gold fish
Green frog
Guppy
H
Halocynthia pyriformis
Hard-shell clam
Hawksbill sea turtle
Hyla regilla
1
Ictalurus natal is
Ic talurus nebulosus
Iguana iguana
Indian monitor lizard
1071-1077
970
1027
1058
1028
1018-1020
1005-1007, 1065-1068
977
1010
1047-1049
971
1037
1050
L
Lacerta sicula
Lake trout
Largemouth bass
Leiostomus xanthurus
Leopard frog
1069
1011, 1026,
917
888-892
920
1046
- 32 -
RTLA NO.
M
Macoma balthlca
Macrozoarces amerlcanus
Meloldogyne Incognita
Mercenarla mercenaria
Micropterus dolomieui
Mic ropterus salmoldes
Microstomas pacificus
N
Northern pike
Northern spiky dogfish
0
Ocean pout
Oncorhynchus keta
Oncorhynchus kisutch
Oncorhynchus nerka
Oncorhynchus tshawytscha
Osmerus mordax
Ostrea lurida
P
Pacific cod
Pacific garter snake
Pacific tree frog
Para lab rax nebulifer
Pickerel frog
Poecilia formosa
Poecilia reticulata
Pseudopleuronectes americanus
Pterophyllum scalare
a
Quahog
R
Rainbow trout
Rainbow trout (Steelhead)
Rana c lamitans
Rana pa lustris
Rana palustris x pipiens
Rana pipiens
Rana pipiens x pa lustris
1004
922, 1015
1017
1005-1007, 1065-1068
1001
917
926
937, 1012, 1031-1035
938
922, 1015
902
1038, 1045
904
903, 940, 1002, 1022, 1023,
1039, 1040
918
930, 981, 1029, 1062A, B, & C
1071-1077
1016
1010
924
1057A & B
893-898, 1021
1028
1013
972
1005-1007, 1065-1068
899, 900, 901, 932, 974, 976,
1003, 1043
928, 931, 942
1058
154, 155, 1057A & B
1051
920, 1052
1053, 1056
33
Red-footed tortoise
Red rattlesnake
Rock fish
Root -knot nematode
Ruin lizard
S
Salmo s^irdneri
Salmo salar
Salmo trutta
Salt water crocodile
Salve linus namaycush
Sceloporus occ identalis
Sea bream
Sea hare
Sea peach
Sebastes sp»
Smallmouth bass
Snapper
Sockeye salmon
Sparus auratus
Speoc irolana bolivari
Spot
Squa lus blainvilli
Stizostedion v it ream vitreum
Symphurus atricauda
T
Tautogolabrus adspersus
Terrapene Carolina
Thamnophis sirtalis
Tiger salamander
Tuxedo swordtail
V
Varanus bengalens is
W
Walleye
Western fence lizard
Winter flounder
X
Xiphophorus helleri
Y
Yellow bullhead
970
984
1025
1017
1069
899-901, 928, 931, 932, 942,
974, 976, 1003, 1043
988
1044
927
1011, 1026, 1046
975
1000, 1059-1061
973
1018-1020
1025
1001
939, 1041, 1042
904
1000, 1059-1061
982
888-892
938
929, 1063
925
923
100 9A & B
986, 1016
905A & B-916, 944-969,
989-999
1024
1050
929, 1063
975
1013
1024
1047-1049
- 34
LIST OF CONTRIBUTORS
ALLEN, D.
National Aquarium
U.S. Department of the Interior
Department of Commerce Building
14th Between E & Constitution
Avenue, N.Wo
Washington, D.Co 20230
RTLA 977
ANDERSON, R. S.
Donald S. Walker Laboratory
Sloan-Kettering Institute for
Cancer Research
145 Boston Post Road
Rye, New York 10580
RTLA 1018-1020
BALLS, M.
Department of Human Morphology
The Medical School
University of Nottingham
Nottingham NG7 2RD, England
RTLA 919
BANFIELD, W« G.
Laboratory of Pathology
National Cancer Institute
National Institutes of Health
Building 10, Room 8B-19
Bethesda, Maryland 20014
RTLA 1027
BELL, G. R„
Pacific Biological Station
Fisheries & Marine Service
Department of the Environment
P.O. Box 100
Nanaimo, B„C. V9R 5K6, Canada
RTLA 903, 928, 942, 1025
BREAM FISHERMEN ASSOCIATION
1333 North Spring Street
Pensacola, Florida 32501
RTLA 1047-1049
BROWN, E. R.
Department of Microbiology
The Chicago Medical School
University of Health Sciences
2020 West Ogden Avenue
Chicago, Illinois 60612
RTLA 937
BRYANT, So Vo
Department of Developmental & Cell Biology
University of California
Irvine, California 92664
RTLA 936
BUC, W. J.
Grayling Field Office
Michigan Department of Natural Resources
P.O. Box 507
Grayling, Michigan 49738
RTLA 1063
CARPENTER, Do 0.
Neurobiology Department
Armed Forces Radiobiology Research Institute
Defense Nuclear Agency
Bethesda, Maryland 20014
RTLA 973
CHANG, S. C.
Registry of Tumors in Lower Animals
National Museum of Natural History
Smithsonian Institution
Washington, D.C. 20560
RTLA 1065-1068
BLASIOIA, Go Co JRo
Steinhart Aquarium
California Academy of Sciences
Golden Gate Park
San Francisco, California 94118
RTLA 1064
BOWMAN, To Eo
Division of Crustacea
National Museum of Natural History
Smithsonian Institution
Washington, D.Co 20560
RTLA 982
COHEN, S.
Permanente Medical Group
13652 Cantara Street
Panorama City, California 91402
RTLA 1028
COLLETTE, Bo B.
NOAA, UoS, Department of Commerce
National Museum of Natural History
Smithsonian Institution
Washington, D.C. 20560
RTLA 1013, 1015
- 35
COLLETTE, Ko W„
c/o B. B. Collette
RTLA 1013
CORNICK, J. Wc
Halifax Laboratory
Fisheries & Marine Service
Department of the Environment
P.O. Box 429
Halifax, N.S. B3J 2R3, Canada
RTLA 918
COSGROVE, G. E.
Biology Division
Oak Ridge National Laboratory
P.O. Box Y
Oak Ridge, Tennessee 37831
RTLA 943, 1008, 1009, 1021
COUCH, J. A.
Gulf Breeze Laboratory
Office of Research & Monitoring
U.S. Environmental Protection
Agency
Sabine Island
Gulf Breeze, Florida 32561
RTLA 1047-1049
FORRESTER, G. R.
Pacific Biological Station
Fisheries & Marine Service
Department of the Environment
P.O. Box 100
Nanaimo, B.C. V9R 5K6, Canada
RTLA 1071-1077
FRYE, F. L.
Berkeley Dog & Cat Hospital
2126 Haste Street
Berkeley, California 94704
RTLA 970, 975, 1010, 1016, 1037, 1050
GAINES, Jo L. JR.
School of Medicine
The University of Alabama in Birmingham
University Station
Birmingham, Alabama 35294
RTLA 971
GATEFF, E. A. F.
Biologisches Institut I (Zoologie) der
Albert-Ludwigs-Universit^t
78 Freiburg IM Breisgau, Schanzlestrasse 9
West Germany
RTLA 933
DEMPSTER, Rc P.
Steinhart Aquarium
Galifornia Academy of Sciences
Golden Gate Park
San Francisco, California 94118
RTLA 920
GHITTINO, Po
Fish Disease Laboratory
Istituto Zooprofilattico Sperimentale
Via Bologna, 148
10154 Torino, Italy
RTLA 1036
ELKAN, E.
Department of His topatho logy
Mount Vernon Hospital
Northwood
Middlesex HA 6 2RN, England
RTLA 985-987, 1069
ENAMAIT, E.
c/o Albert Powell Hatchery
Route One, Box 180
Hagerstown, Maryland 21740
RTLA 929
EVELYN, T. Po T.
Pacific Biological Station
Fisheries & Marine Service
Department of the Environment
P.O. Box 100
Nanaimo, B.G. V9R 5K6, Canada
RTLA 902, 1011, 1012
HARSHBARGER, J. G.
Registry of Tumors in Lower Animals
National Museum of Natural History
Smithsonian Institution
Washington, D.G. 20560
RTLA 1065-1068
HART, Ro W.
The College of Medicine Facilities
The Ohio State University Hospitals
410 West 10th Avenue
Columbus, Ohio 43210
RTLA 893-898
HERMAN, R. L.
Eastern Fish Disease Laboratory
U.S. Department of the Interior
Leetown, Route One
Kearneysville, West Virginia 25430
RTLA 917
- 36 -
HINE, P. M.
Fisheries Research Division
Ministry of Agriculture & Fisheries
P.O. Box 19062
Wellington, New Zealand
RTLA 938, 939, 972, 1002, 1041-1044,
1070
HOLZINGER, E. W.
Diagnostic Assistance Laboratory
College of Veterinary Medicine
The University of Georgia
Athens, Georgia 30602
RTLA 984
HOSKINS, Go E.
Pacific Biological Station
Fisheries & Marine Service
Department of the Environment
P.O. Box 100
Nanaimo, B.C. V9R 5K6, Canada
RTIA 1026, 1038-1040
HOTCHKISS, Fo Ho C.
Division of Natural Sciences
State University of New York
College at Purchase
Purchase, New York 10577
RTLA 978
HNATH, J. Go
Wolf Lake Pathobiology Laboratory
Wolf Lake Hatchery
Michigan Department of Natural
Resources
Route One
Mattawan, Michigan 49071
RTL4 940, 988, 1045, 1046
HUFF, Jo A.
Marine Research Laboratory
State of Florida Department of
Natural Resources
100 Eighth Avenue, S.E.
St. Petersburg, Florida 33701
RTLA 979, 980
ISHIKAWA, To
Department of Experimental
Pathology
Cancer Institute
Kami-Ikebukuro, Toshima-ku
Tokyo, Japan
RTLA 1024
KERN, F. G.
Biological Laboratory
National Marine Fisheries Service, NOAA
U.S. Department of Commerce
Oxford, Maryland 21654
RTLA 1004
KIMURA, I.
Laboratory of Viral Oncology
Research Institute, Aichi Cancer Center
Chikusa-ku, Nagaya, Japan
RTIA 935
LANDOLT, M. L.
Washington Cooperative Fisheries
Research Unit
College of Fisheries WH-10
University of Washington
Seattle, Washington 98195
RTLA 927
LJUNGBERG, 0.
Department of Anatomy & Histology
Royal Veterinary College & National
Veterinary Institute
S-104 05 Stockholm, Sweden
RTLA 1031-1035
LLOYD, R.
National Aquarium
U.S. Department of the Interior
Department of Commerce Building
14th Between E & Constitution Avenue, N.W.
Washington, D.C. 20230
RTLA 977
MIX, M. C.
Department of General Science
Oregon State University
Corvallis, Oregon 97331
RTLA 930, 981, 1029, 1062
MULCARE, D. J,
College of Arts & Sciences
Southeastern Massachusetts University
North Dartmouth, Massachusetts 02747
RTIA 1051-1058
OTTO, S. V„
Maryland Department of Natural Resources
c/o Biological Laboratory
U.S. Department of Commerce
Oxford, Maryland 21654
RTLA 1005-1007, 1065-1068
37
OVERSTREET, R. M.
Parasitology Section
Gulf Coast Research Laboratory
P.Oo Drawer AG
Ocean Springs, Mississippi 39564
RTLA 888-892
PAPERNA, I.
The Heinz Steinitz Marine Biology
Laboratory
The Hebrew University of Jerusalem
P.O. Box 469
Eilat, Israel
RTLA 1000, 1059-1061
QUICK, J. Ao JRo
Marine Research Laboratory
State of Florida Department of
Natural Resources
100 Eighth Avenue, SoE.
St. Petersburg, Florida 32304
RTLA 979, 980
ROBERTS, R. J.
Unit of Aquatic Pathobiology
University of Stirling
Stirling FK9 4LA, Scotland
RTLA 974
ROSE, F. L„
Department of Biological Sciences
Texas Tech University
P.O. Box 4149
Lubbock, Texas 79409
RTLA 905-916, 944-969, 989-999
ROTHENBACHER , H„
Department of Veterinary Science
The Pennsylvania State University
115 Animal Industries Building
University Park, Pennsylvania 16802
RTLA 1001
SAYRE, R. M„
Nematology Laboratory
Agricultural Research Center, West
U<,S. Department of Agriculture
Beltsville, Maryland 20705
RTLA 1017
SCHOKNECHT, R.
Museum of Comparative Zoology
at Harvard College
Cambridge, Massachusetts 02138
RTLA 1014
SHERWOOD, M. J.
Southern California Coastal Water Research
Proj ect
1500 East Imperial Highway
El Segundo, California 90245
RTLA 924-926
SHUMWAY, S. E.
N.E.R.C. Unit
Marine Science Laboratories
University College of North Wales
Menai Bridge
Anglesey LL59, 5EH, Wales
RTLA 923
SMITH, Ao C.
Department of Clinical Pathology
University of Hawaii School of Medicine
St. Francis Hospital
2260 Liliha
Honolulu, Hawaii 96817
RTLA 941
SMITH, C. Eo
Fish Cultural Development Center
U.S. Department of the Interior
Route 2, Box 333
Bozeman, Montana 59715
RTLA 899-901, 904
SNYDER, R. L.
Penrose Research Laboratory
Philadelphia Zoological Garden
34th Street & Girard Avenue
Philadelphia, Pennsylvania 19104
RTLA 1030
SONSTEGARD, R.
Department of Microbiology
University of Guelph
Guelph, Ontario, Canada
RTLA 934
VAN DE KERKHOFF, J.
KIWA, Mariahoeve
De Wiers 17
Nieuwegein, The Netherlands
RTLA 976
WOLF, H,
Fish Disease Laboratory
California Department of Fish & Game
2111 Nimbus Road
Rancho Cordova, California 95670
RTLA 931, 932, 1003
WOLF, P»
New South Wales State Fisheries
Laboratories
211 Kent Street
Sydney 2000, Australia
RTLA 921, 983
WOLKE, R. E.
Seagrant Pathology Laboratory
University of Rhode Island
Kingston, Rhode Island 02881
RTLA 922
YASUTAKE, W. T.
Western Fish Disease Laboratory
Fish & Wildlife Service
UoS. Department of the Interior
Building No. 204
Naval Support Activity
Seattle, Washington 98115
RTLA 1022, 1023
•1^- ■•- ■■.•,::,;.\t
-.u.,
TEAR OUT ACCESSION SHEET
PLEASE SUBMIT TO:
Dr. John C, Harshbarger
Registry of Tumors in Lower Animals
National Museum of Natural History
Room W216-A
Smithsonian Institution
Washington, D.C., 20560, USA
DATE RECD. _
CONTRIBUTOR'S N0„
RTLA NOo _
USNM NO. _
NIH HISTOPATH NO.
COMMON NAME _ FAMILY _
PHYLUM _ _ GENUS _
CLASS _ SPECIES _ ;
ORDER _
CATEGORY: NEOPLASM _ INFLAMMATION _ INFEGTION _ PARASITIC _ TOXIC
DEVELOPMENTAL _ TRAUMATIC _ NORMAL _ OTHER _
CONTRIBUTOR (NAME & ADDRESS): COLLECTOR (NAME & ADDRESS):
ITEMS SUBMITTED (QUANTITY):
GROSS MATERIAL _ PHOTOGRAPHS _
SLIDES _ REPRINTS _
BLOCKS _ _ OTHER _
ORIGIN OF ANIMAL: MARINE _ FRESHWATER _ ESTAURINE
WHERE COLLECTED _
TERRESTRIAL
date collected _ SEX _ AGE _ STAGE OF LIFE CYCLE
HOW KILLED _ FIXATION _
GROSS DESCRIPTION _
MICROSCOPE DX
COMMENTS (e.gc, possible exposure to chemical pollutants or infectious agents, in¬
cidence and duration of this condition in the population, etc.)
(Please use reverse side, if more space is needed)
■■
■ ’''''rh
.'ll
r¥'>Sa
I
w
j'/O .
fqaR33
]Lr)Ver'+
ACTIVITIES REPORT
REGISTRY OF TUMORS IN LOWER ANIMALS:
1975 SUPPLEMENT
JOHN C. HARSHBARGER, DIRECTOR
PREPARED FOR DISTRIBUTION BY:
REGISTRY. OF TUMORS IN LOWER ANIMALS
NATIONAL MUSEUM OF NATURAL HISTORY
ROOM W-216A
SMITHSONIAN INSTITUTION
WASHINGTON, D.C. 20560
Contract No. NOl-CB-33874; Contractor: Smithsoi
CONTENTS
SPECIMEN COLLECTION . 1
TABLE I - DISTRIBUTION OF LESIONS AMONG
SPECIMENS ACCESSIONED . 2
REFERENCE LIBRARY . 4
PAPERS PUBLISHED SINCE 1974 . 4
OTHER ACTIVITIES IN 1975 . 5
PERSONNEL . . . 6
ACCESSIONS . 7
INDEX OF NEOPLASM - ANIMAL GROUP - AND
RTLA NUMBER . 28
PHYLOGENETIC INDEX . 30
INDEX OF SPECIMENS BY SCIENTIFIC AND
COMMON NAMES . 33
LIST OF CONTRIBUTORS . 38
TEAR OUT ACCESSION SHEET
LAST PAGE
1
The activities of the Registry during 1975 reflected an increased interest
in the cause and significance of neoplasia in invertebrate and cold-blooded
vertebrate animals. As pointed out in the two previous activities reports
(copies of which are still available) there are numerous proven and hypothe¬
sized benefits from studying neoplasms in lower animals including the dis¬
covery of: new carcinogens, indicators of carcinogens in the environment,
vectors of cancer viruses, reservoirs of chemical carcinogens, multipliers
of carcinogens in the food chain, models for the study of mechanisms of
neoplastic transformation, sources of anti-cancer compounds, and models for
screening the carcinogenicity and mutagenicity of new chemicals. Protection
of animal populations from epizootic neoplasia and research spinoff in re¬
lated fields can be added to this list.
SPECIMEN COLLECTION
The specimen collection is the most important component of the Registry’s
mission and we invite contributions of any material showing neoplasms or
related diseases in cold-blooded vertebrates and invertebrates. The ma¬
terial will be processed as required and where applicable a set of micro¬
scope slides will be returned with the diagnosis. Almost all of the cases
received add to the information on geographic and phylogenetic distribu¬
tion of these diseases and their manifestation within the organism. In ad¬
dition, many of the cases have special significance as they relate to one
of the benefits mentioned above. Unfortunately a report such as this does
not portray the total significance of each case, but in conjunction with
the literature it will give one a fair estimation of where we stand.
In 1975 the specimen collection increased by 305 accessions, which repre¬
sented a 62% increase over those received in 1974. The complete list of
specimens with the diagnosis, name of contributor, and pertinent reference
when applicable, is included in this report. Table I gives a breakdown of
the major phylogenetic groups with the ratio of neoplastic to non-neoplas¬
tic lesions. The bulk of the specimens are bony fish and bivalve mollusks.
Approximately two-thirds of the diagnosed material was neoplastic, but
mollusca and arthropoda continue to be the only invertebrate phyla from
which verifiable neoplasms are known.
Among the accessions of special interest were 47 hagfish cases having
hepatocellular, cholangiocellular , and/or islet cell adenomas and adeno¬
carcinomas. These cases, representing the only known neoplasms of this
primitive vertebrate, were discovered in a Baltic Fjord by Sture Falkmer.
Incidence decreased from 5.8% (liver lesions) and 0.5% (islet organ le¬
sions) in 1972 to 0.6% and 0.1% respectively in 1974. The cause has not
been determined.
Also of note were 102 cases from the soft-shell clam, Mya arenarla , pri¬
marily with germinomas and hematopoietic neoplasms. These animals were
from an area where spillage of refined petroleum products has occurred.
Incidence has averaged 4-5% in about 3,000 animals surveyed since 1971.
Incidence of approximately 850 animals collected away from the oil spill
site is 0. 3-0.4%.
DISTRIBUTION OF LESIONS AMONG SPECIMENS ACCESSIONED
2
• o^
O fO
c o
0) c
a w
OJ -H
P-(
3
Other cases of interest included: (1) a parabranchial body adenoma in a
rockfish (RTLA 1079) received from Gordon Bell and Gary Hoskins. These
are well known in Pacific and Atlantic cod but were previously unknown in
rockfish; (2) a hematopoietic neoplasm in an Australian oyster, Crassostrea
commercialis , (RTLA 1117) from Peter Wolf. Mr. Wolf has discovered well
over 100 epidermal papillomas in the mantle of this oyster but this is only
the second hematopoietic lesion; (3) ossifying dermal fibromas in mullet
(RTLA 1111) and southern flounder (RTLA 1112) were contributed by Robin
Overstreet. Donald Lightner has also found lesions of this type in mullet
(RTLA 807 and 821) and Tom. Wright and Dave Tomljanovich have found them in
sauger (RTLA 823) . Frank Schwartz contributed an ossifying fibroma in the
jaw of a crevalle jack (RTLA 1233); (4) Fredric Frye contributed a second
palatine chondromyxof ibroma from a tree frog (RTLA 1080) ; (5) Robert Wolke
discovered a second striped bass nephroblastoma (RTLA 1124) ; (6) the first
metastatic fish nephroblastoma occurred in a crucian carp, Carassius carassius ,
(RTLA 1153) submitted by David Bucke; (7) a metastatic pancreatic carcinoma fn
a tiger salamander, Amby stoma tigrinum, was submitted by Francis Rose (RTLA
1226) . Approximately 50% of the salamanders living in the same sewage set¬
tling lagoon have skin neoplasms, some of which are highly invasive, but
this is the first case of a metastatic cancer in this population; (8) the
first plasma cell tumor in a reptile was in a cotton mouth moccasin sub¬
mitted by E.P. Finnie (RTLA 1176); (9) three additional cases of benign
polypoid neoplasms were discovered in bivalve mollusks. One in an Ostrea
lurida (RTLA 1168) and one in a Crassostrea virginica (RTLA 1228) discovered
by Michael Mix and by Sara Otto respectively originated from connective tis¬
sue proximal to the pericardium. The third case was a myoma of the foot of a
surf clam, Spisula solidissma, (RTLA 1227) discovered by Louis Leibovitz; (10)
two cases of bile duct adenof ibrosis in white perch (RTLA 1226 and 1234) were
discovered by Todd Beckerman and R.P. Morgan, II. Similar lesions can be
induced in rat livers with hepatotoxic chemicals which suggest the perch may
have been responding to an environmental pollutant. A similar case in a
Siganus rivulatus (RTLA 1236) was submitted by Ilan Paperna; (11) during a
routine autopsy of an apparently healthy spiny dogfish shark caught for ex¬
perimental purposes, a papilloma of the choroid plexus (RTLA 1221) was dis¬
covered by Anthony Guarino, David Prieur, and Joseph Fenstermacher ; (12) a
komodo dragon received as a diplomatic present to the U.S. and housed at the
National Zoo in Washington, D.C., began exhibiting intestinal disorders in
1973 and died in 1975 of congestive heart failure. Autopsy showed adenocar-
cinomatous lesions in colon, spleen, adrenal and pancreas, plus tumor emboli
in blood vessels. The case (RTLA 1166), investigated by Richard Montali of
the National Zoo, is the only neoplasm known from this reptilian species.
An ancient encapsulated hematoma was also found in its foot pad by Charles
Ross as the hide was being preserved; (13) material was received from thyroid
hyperplasias and neoplasias in a variety of fish. It is difficult to make a
definitive diagnosis of adenocarcinoma in fish thyroids because fish fre¬
quently get goiterous hyperplasias from lack of iodine or exposure to thy¬
roid toxins such as thiourea. Since fish thyroids are unencapsulated, the
hyperplastic follicles from goiters often invade but do not destroy nor¬
mal tissues and can even be seen separating muscle fibers. RTLA 1099-1103
were Amazon mollies from Ronald Hart, with greatly enlarged thyroids. The
hyperplastic follicles showed extensive tissue damage and local invasion thus
favoring an interpretation of thyroid carcinoma. RTLA 1155 and 1157 were
roaches from David Bucke with probable thyroid carcinomas although postmortem
. 4 -
change prevented an unqualified diagnosis. RTLA 1167 was an opaleye with a
thyroid adenoma submitted by Roger Herman. RTLA 1208 was a Coris f lavovittata
with a thyroid adenoma from Robert Bourke. RTLA 1219 was a golden trout with
either a thyroid or a renal adenocarcinoma from Charlie Smith and RTLA 1224
were several spots with thyroid hyperplasias from Gerry Cosgrove; (14) five
fish neural sheath tumors were received: neurilemmomas in a sculpin from G.N.
Swinney (RTLA 1078); in a goldfish from Ron Roberts (RTLA 1091); in a rainbow
smelt from Vance Logan and Paul Odense (RTLA 1163) ; and in a snapper from
Mike Sigel (RTLA 1378). A neurilemmal sarcoma was submitted in a Pseudo-
tropheus tropheops from George Blasiola, Jr. (RTLA 1270); (15) epidermal
papillomas from Dover sole (RTLA 1082-4) and a white croaker (RTLA 1086)
were submitted by Dilworth Chamberlain. An epidermal papilloma from a bull¬
head (RTLA 1376) was received from Kenneth Wolf; (16) epizootic multiple
myopathic granulomas of unknown etiology in skeletal muscle of walleyes (RTLA
1136-46) are being studied by Philip Economon; (17) a testicular leiomyoma in
a kahawai was submitted by P.M. Hine (RTLA 1172); (18) Ted Meyers submitted
tissue from the heart of an Atlantic sturgeon showing normal hematopoiesis
associated with the epicardium of the heart (RTLA 1118); and, (19) an in¬
vasive melanoma from a chinook salmon was submitted by John Hnath (RTLA 1269) .
REFERENCE LIBRARY
Approximately 150 papers were added to the comprehensive library on neoplasms
in lower animals bringing the total to 2,950. Except for recent acquisitions
and articles that need to be translated, all papers have been abstracted by
selected key words and computerized.
PAPERS SINCE 1974
Dawe, C.J. and J.C. Harshbarger. Neoplasms in Feral Fishes: Their Signifi¬
cance to Cancer Research. In: The Pathology of Fishes, W.E. Ribelin and
G. Migaki (ed.), Chapter 35, pp. 871-94. The University of Wisconsin
Press: Madison and London. 1975.
Frye, F.L., J.D. Carney, J.C. Harshbarger, and R.F. Zeigel. Malignant
Chromatophoroma in a Western Terrestrial Garter Snake. J. Amer. Vet. Med.
Assoc., ]^: 557-8. 1975.
Harshbarger, J.G. Registry of Tumors in Lower Animals. In: 0. Bessey, Status
of Marine Biomedical Research. Environ. Health Perspect., ]3: 152-4. 1976.
Harshbarger, J.C., S.E. Shumway, and G.W. Bane. Variably Differentiating
Oral Neoplasms, Ranging from Epidermal Papilloma to Odontogenic Amelo¬
blastoma, in Gunners Tautogolabrus adspersus (Osteichthyes ; Perciformes;
Labridae) . In: Progress in Experimental Tumor Research, Vol. 20, Neoplasms
in Aquatic Animals as Indicators of Environmental Carcinogens. F. Homberger
(ed.), pp. 113-28. Karger: Basel. 1976.
Billups, L.H. and J.C. Harshbarger. Section XII: "Reptiles" of Chapter 6,
"Naturally Occurring Neoplastic Diseases of Laboratory Animals". In: CRC
Handbook of Laboratory Animal Science, Vol. 3, E.C. Melby, Jr. and N.”.
Altman (ed.). CRC Press: Cleveland. (In press).
5
Harshbarger, JoCo Spontaneous Neoplasms in Amphibians , a Section of Chapter
1; "Tumors,” in: Pathology of Laboratory Animals , Vol. 2, Ko Benirschke,
F„Mo Gamer, ToCc Jones, and Co Kozma (ed.)o Springer-Verlag ; New Yorko
(In press)o
OTHER ACTIVITIES IN 1975
1. Hosted and addressed a Marine Biomedical Research Meeting, sponsored by
the National Institute of Environmental Health Sciences on 13-14 February
1975 [Bessey, 0. Status of Marine Biomedical Research, Environ., Health
Perspect., 147-63, 1976; also summarized as Marine Biomedical Sci¬
entists Exam.ine Harvest of Knowledge from the Sea, The NIH Record, 27 (6) ;
4-5, 25 March 1975]o
2o Served as Secretary of the UICC Committee on Comparative Oncology (chaired
by Code Dawe of the UoSo National Cancer Institute) o
3o Conducted research on integumentary neoplasms in cunners, catfish, and
salamanders under the auspices of the above Committee.,
4„ Presented the report, "Malignant Lymphomas of Fish in the Collection of
the Registry of Tumors in Lower Animals," at the First International
Workshop on Malignant Lymphoma in Esocidae held in Stockholm on 9-11
October 1975o
5. Attended the Vllth International Symposium on Comparative Research on
Leukemia and Related Diseases held in Copenhagen on 13-17 October 1975.
6o Collected catfish specimens and consulted with Dro John Couch (Environ¬
mental Research Laboratory, UoSo Environmental Protection Agency, Gulf
Breeze, Florida on 5-10 December 1975) on a collaborative study of epi¬
dermal and melanophore neoplasms of catfish„ Also gave a seminar to
the Laboratory's staffo
7o Consulted with personnel of the Mt . Desert Island Biological Laboratory,
Salsbury Cove, Maine on 29-30 July 1975 and presented a seminar on the
current status and benefits that may accrue from the study of neoplasms
in invertebrate and cold-blooded vertebrate animals emphasizing the ac¬
tivities of the Registry of Tumors in Lower Animals.
8o Presented two papers at, and co-authored a third for, the Vlllth An¬
nual Meeting of the Society for Invertebrate Pathology and attended
the Executive Council Meeting as the Society's Secretary on 18-21
August 1975 in Corvallis, Oregon.
9o Participated in the planning and addressed a Workshop on Molluscan
Pathology held at the Wye Institute, Wye Mills, Maryland on 3-5 Sep¬
tember 1975o
lOo Served as Secretary of the Washington, DoC., Chapter of Sigma Xi, The
Scientific Research Society of North America o
6
11. Served on the Interagency Collaborative Group on Environmental Carcino¬
genesis (chaired by H.F. Kraybill of the U.S. National Cancer Institute)
12. Served as Secretary for the Society for Invertebrate Pathology.
13. Served as a member of the Committee on Animal Models and Genetic Stocks
of the National Research Council of the National Academy of Sciences.
14. Participated in a cooperative investigation of the etiology of several
diseases of bivalve mollusks, supported in part by the U.S. Food and
Drug Administration.
15. Served as a member of the Planning Committee for a New York Academy of
Sciences sponsored Conference entitled: "Aquatic Pollutants and Bio¬
logical Effects With Emphasis on Neoplasia" to be held 27-29 September
1976 in New York City.
16. Participated in a meeting to assess the need for a new journal and a new
society for comparative pathology held at the Eastern Virginia Medical
School in Norfolk, Virginia, hosted by Daniel Cowan and Sanford Vernick,
on 1 December 1975.
17. Was interviewed on several occasions by reporters interested in writing
semi-popular articles on the biomedical effects of environmental pollu¬
tion. Some of the resulting articles were: (1) Ember, Lois. The Specter
of Cancer, Environ. Sci. Tech., ^(13): 1117-21, 1975; (2) Brett, Abigail
Trafford. Fish: Man’s Early Warning System, The Washington Post, section
B, page 3, Sunday, 14 September 1975; and, (3) Pendelton, Deedee. Fish
Tumors: Carcinogenic Indicators? Sci. News, 107(10) : 157-8, 8 March 1975
PERSONNEL
The Project Officer for the contract is Dr. Clyde J. Dawe, Head, Comparative
Oncology Section, Laboratory of Pathology, National Cancer Institute, Na¬
tional Institutes of Health, Bethesda, Maryland, 20014.
The Principal Investigator for the contract is Dr. W. Duane Hope, Chairman,
Department of Invertebrate Zoology, National Museum of Natural History,
Smithsonian Institution, Washington, D.C., 20560.
The staff of the Registry is
John C. Harshbarger, Ph.D.
Sing Chen Chang, Ph.D.
Phyllis M. Schellenger, B.S.
Linda J. Cullen, B.A.
Judith E. Foster, B.S.
Marilyn -^latick, B.S.
as follows:
- Director
- Electron Microscopist
- Registrar
- Histopathology Technician
- Bibliographer and Histopathology Technician
- Bibliographer
7
ACCESSIONS
RTLA 1078. Sculpin, Cottus gobio
Material: Posterior portion of specimen with a growth below the
dorsal fin
Diagnosis: Neurilemmoma
Submitter: G. N. Swinney
RTLA 1079. Rockfish, Sebastes sp.
Material: Cleithrum area with a spongy, convoluted growth
Diagnosis: Parabranchial body adenoma
Submitter: G. E. Hoskins
RTLA 1080. Pacific tree frog, Hyla regilla
Material: A piece of tissue from palate
Diagnosis: Chondromyxoma
Submitter: F. L. Frye
RTLA 1081. Speckled sanddab, Citharichthys stigmaeus
Material: One gross specimen with missing right eye
Diagnosis: Probable physical injury
Submitter: D. W. Chamberlain
RTLA 1082. Dover sole, Microstomus pacificus
Material: One gross specimen with a lesion on the lower lip and
a lesion on the caudal fin
Diagnosis: Epidermal papillomas coexistent with extensive in¬
flammation
Submitter: D. W. Chamberlain
RTLA 1083. Dover sole, Microstomus pacificus
Material: One gross specimen with a growth located in a mid-lateral
position below the lateral line and involving a portion
of the anal fin
Diagnosis: Epidermal papilloma
Submitter: D. W. Chamberlain
RTLA 1084. Dover sole, Microstomus pacificus
Material: One gross specimen with three growths — one each on
the pectoral, caudal, and anal fins
Diagnosis: Epidermal papillomas
Submitter: D. W. Chamberlain
RTLA 1085r- White seaperch, Phanerodon furcatus
Material: One gross specimen with an eroded operculum on the
left side
Diagnosis: Possible mechanical Injury
Submitter: D. W. Chamberlain
RTLA 1086. White croaker, Genyonemus lineatus
Material: One gross specimen with two similar growths attached to
the upper lip in opposite corners of the mouth
Diagnosis: Epidermal papillomas
Submitter: D. W. Chamberlain
- 8 -
RTLA 1087. Largescale sucker, Catostomus macrocheilus
Material: Anal fin and adjoining body wall and growth
Diagnosis: Myoblastoma
Submitter: C. D. Becker
RTLA 1088-9. Mussel, Mytilus edulis
Material: One gross specimen each with a growth on the foot
Diagnosis: Parasitic abscess
Submitter: S. E. Shumway
RTLA 1090. Brown trout, Salmo trutta
Material: Caudal peduncle with a black, gelatinous growth
Diagnosis:, Myxofibrosarcoma
Submitter: P. M. Hine
RTLA 1091. Goldfish, Carassius auratus
Material: Two microscope slides; 1 color transparency
Diagnosis: Neurilemmoma or a neurofibroma
Submitter: R. J. Roberts
RTLA 1092. Hard-shell clam, Mercenaria mercenaria
Material: Fixed digestive diverticula tissue; 3 microscope slides
Diagnosis: Chlamydia inclusions
Submitter: S. V. Otto, J. C. Harshbarger, and S. C. Chang
RTLA 1093. Sitana ponticeriana
Material: One microscope slide; 1 color transparency
Diagnosis: Bacterial granuloma of the dermis accompanied by
epidermal hyperplasia
Submitter: G. Matz
RTLA 1094. Carp, Cyprinus carpio
Material: One microscope slide
Diagnosis: Fibromyxoma versus inflammatory polyp
Submitter: G. Migaki
RTLA 1095. Croaker
Material: One eye with a mass of tissue at the margins
Diagnosis: Edematous conjunctiva due to infection with trematode-
llke parasites
Submitter: W. Kandrashoff
RTLA 1096. Striped (black) mullet, Mugil cephalus
Material: Crooked pectoral fin
Diagnosis: Double fracture of fin spine associated with parasitic
granulomas
Submitter: W. Kandrashoff
RTLA 1097-8. Menhaden, Brevoortia sp.
Material: One crooked caudal fin each
Diagnosis: Double fracture of fin spine associated with parasitic
granulomas
Submitter: W. Kandrashoff
9
RTLA 1099-1103.
Material:
Diagnosis :
Submitter:
Amazon molly, Poecllia formosa
One gross specimen each
Marked hyperplasia versus carcinoma of thyroid
R. W. Hart
RTLA 1104. Sea urchin
Material: One gross specimen with enlarged deformed spines
Diagnosis: Pending
Submitter: M. E. Downey
RTLA 1105. Amazon molly, Poecllia formosa
Material: Twenty-four gross specimens
Diagnosis: Normal
Submitter: R. W. Hart
RTLA 1106. Tunicate, Ascidiella sp.
Material: One partially dissected specimen with an abnormally
enlarged cerebral ganglion/neural gland region
Diagnosis: Multiple cysts containing protozoa
Submitter: L. M. Laird
RTLA 1107. Corn
Material :
Diagnosis:
Submitter :
Reprint :
snake, Elaphe guttata guttata
Four microscope slides; 2 paraffin blocks
Parasitic granuloma of algal (Protothecosa sp.) etiology
G. C. Crispens, Jr.
Crispens, Charles G. , Jr. and Ken R. Marion. Algal In¬
fection in a Corn Snake (Elaphe guttata guttata) . Lab.
Anim. Sci. , 2^: 788-9. 1975.
RTLA 1108. Shortfin eel, Anguilla australis
Material: Head with swollen lips and tail with patches of mucus;
3 microscope slides; 2 black and white photographs
Diagnosis: Hyperplastic epidermis with hypertrophic goblet cells
Submitter: P. M. Hine
RTLA 1109. Scissorstail, Rasbora trilineata
Material: One gross specimen with a growth involving the right
side of the head anterior to the eye
Diagnosis: Adenocarcinoma of unknown origin
Submitter: G. C. Blasiola, Jr.
RTLA 1110. Shortfin eel, Anguilla australis
Material: A piece of skin with attached underlying tissue con¬
taining a cyst-like structure
Diagnosis : Pending
Submitter: P. M. Hine and N. C. Boustead
RTLA 1111. Striped mullet, Mugil cephalus
Material: Two microscope slides
Diagnosis: Dermal fibroma with areas of ossification
Submitter: R. M. Overstreet
Reprint: Edwards, R. H. and R. M. Overstreet. Mesenchymal Tumors of
Some Estuarine Fishes of the Northern Gulf of Mexico. I.
Subcutaneous Tumors, Probably Fibrosarcomas, in the Striped
Mullet, Mugil cephalus. Bull. Mar. Sci., 33-40. 1976.
10
RTLA 1112. Southern flounder, Paralichthys lethostigma
Material: Two microscope slides
Diagnosis; Subcutaneous fibroma
Submitter; R. M. Overstreet
Reprint: Overstreet, Robin M. and Robert H. Edwards. Mesenchjrmal
Tumors of Some Estuarine Fishes of the Northern Gulf of
Mexico. II. Subcutaneous Fibromas in the Southern Floun¬
der, Paralichthys lethostigma, and the Sea Catfish, Arius
felis. Bull. Mar. Sci., 41-48. 1976.
RTLA 1113. Sea catfish, Arius felis
Material: Two microscope slides
Diagnosis: Subcutaneous chondro fibroma
Submitter: R. M. Overstreet
Reprint: (See RTLA 1112)
RTLA 1114 . Boa constrictor
Material; Two paraffin blocks
Diagnosis: Intussusception (ileal)
Submitter: E. Elkan
RTLA 1115. Boa constrictor
Material; One paraffin block
Diagnosis: Possible Anitschkow myocyte tumor
Submitter: E. Elkan
RTLA 1116. Boa constrictor
Material: Two paraffin blocks
Diagnosis; Lymphocytic thyroiditis resembling Hashimoto's disease
Submitter; E. Elkan
RTLA 1117. Sydney rock oyster, Crassostrea commercialis
Material: Two microscope slides
Diagnosis: Hematopoietic neoplasm co-existent with a haplosporldan
infection
Submitter: P. H. Wolf
RTLA 1118. Atlantic sturgeon, Acipenser oxyrhynchus
Material: One microscope slide; 1 paraffin block
Diagnosis; Normal hematopoietic tissue peripheral to heart
Submitter: T. R, Meyers
RTLA 1119. Coho salmon, Qncorhynchus kisutch
Material: One microscope slide; 2 black and white photographs;
1 color transparency
Diagnosis: Glochidia from Margarltlf era margarltif era producing
epithelial and stromal hyperplasia from host
Submitter: T. R. Meyers
Reprint: Master's thesis; Susceptibility of Juvenile Salmonid
Fishes to Infection with Glochidia of Margaritifera
margaritifera (L.) (Pelecypoda: Margaritanidae) .
11
RTLA 1120. Chinook salmon, Oncorhynchus tshawytscha
Material: One microscope slide; 3 black and white photographs;
1 color transparency
Diagnosis: Glochidia from Margaritif era margaritif era producing
epithelial and stromal hyperplasia from host
Submitter: T. R. Meyers
Reprint : (See RTLA 1119)
RTLA 1121. Summer flounder, Paralichthys dentatus
Material: One microscope slide
Diagnosis: Stephanostomum sp. metacercariae — encysted
Submitter: T. R. Meyers
RTLA 1122. Copepod, Lernaeenicus radiatus
Material: One gross specimen with thin, white, wing-like material
streaming from the abdomen
Diagnosis: Parasitic fungi
Submitter: T. R. Meyers
RTLA 1123. Striped bass, Morone saxatilis
Material: One piece of tissue containing a segment of a 10x4x1.5 cm
reddish-brown lesion in flank muscle; 2 microscope slides;
2 paraffin blocks
Diagnosis: Scar
Submitter: D. E. Zwerner
RTLA 1124. Striped bass, Morone saxatilis
Material: Four pieces of tissue; 1 microscope slide
Diagnosis: Nephroblastoma
Submitter: R. E. Wolke
RTLA 1125-6. Oyster, Crassostrea virginica
Material: Three microscope slides each; 1 paraffin block each
Diagnosis: Rickettsia-like inclusions
Submitter: S. V. Otto
RTLA 1127-30. Soft-shell clam, Mya arenaria
Material: Three microscope slides each; 1 paraffin block each
Diagnosis: Rickettsia-like inclusions
Submitter: S. V. Otto
RTLA 1131. Boa constrictor
Material: Four microscope slides; 1 paraffin block
Diagnosis: Subcutaneous multiple mycotic granulomas
Submitter: C. G. Crispens, Jr.
RTLA 1132. American toad, Bufo americanus
Material: Two microscope slides from small yellow growth near tympanum
Diagnosis: Probably a type of xanthosis
Submitter: C. L. Counts, III
RTLA 1133. Tiger salamander, Ambystoma tigrinum
Material: One piece of tissue
Diagnosis: Fibrosarcoma
Submitter: F. L. Rose
12
RTLA 1134. Mussel shrimp, Gigantocypris muelleri
Material: Left seventh limb
Diagnosis: Probable physical injury
Submitter: L. S. Kornicker
RTLA 1135. Red-spotted newt, Notophthalmus vlrldescans
Material: One gross specimen from which a growth had been removed
from the neck and the excised growth; 2 microscope slides
1 paraffin block; 2 black and white photographs
Diagnosis: Neural neoplasm — type undetermined
Submitter: C. L. Counts, III
RTLA 1136. Walleye, Stizostedion vitreum vltreum
Material: One piece of tissue; 1 microscope slide; 1 paraffin
block; 1 laboratory report
Diagnosis: Multiple myopathic granulomas — etiology undetermined
Submitter: P. P. Econoraon
RTLA 1137-9. Walleye, Stizostedion vitreum vitreum
Material: One piece of tissue each
Diagnosis: Normal
Submitter: P. P. Economon
RTLA 1140. Walleye, Stizostedion vitreum vitreum
Material: Two pieces of tissue; 1 laboratory report
Diagnosis: Multiple myopathic granulomas — etiology undetermined
Submitter: P. P. Economon
RTLA 1141. Walleye, Stizostedion vitreum vitreum
Material: Three pieces of tissue; 4 color transparencies; 3 black
and white photographs; 1 laboratory report
Diagnosis: Multiple myopathic granulomas — etiology undetermined
Submitter: P. P. Economon
RTLA 1142-5. Walleye, Stizostedion vitreum vitreum
Material: One piece of tissue each; 1 laboratory report each
Diagnosis: Multiple myopathic granulomas — etiology undetermined
Submitter: P. P. Economon
RTLA 1146. Walleye, Stizostedion vitreum vitreum
Material: Two pieces of tissue; 4 microscope slides; 10 color
transparencies; 1 laboratory report
Diagnosis: Multiple myopathic granulomas — etiology undetermined
Submitter: P. P. Economon
RTLA 1147. Yellow rat snake, Elaphe obsolete quadrivittata
Material; One gross specimen with distended oviduct
Diagnosis: Acute bacterial infection, inf lamination, and necrosis
Submitter: I. L. C. Gorman
RTLA 1148. Geoduck, Panope generosa
Material: A pigmented lesion from the siphon
Diagnosis: Adherent material
Submitter: A. C. Smith
13
RTLA 1149. Chum
Material:
Diagnosis:
Submitter :
salmon, Oncorhynchus keta
A portion of the tail with a large growth
Osteoma
G. R. Bell
RTLA 1150. Tropical red-eared turtle, Chrysemys ornata callirostris
Material: One piece of tissue; 4 microscope slides; 1 black and
white photograph
Diagnosis: Multiple granulomas of spleen with amyloid deposits —
etiology unknown
Submitter: E. Elkan
RTLA 1151. Lake trout, Salvelinus namaycush
Material: Five pieces of liver tissue; 5 microscope slides
Diagnosis: Hemangioendothelioma arising from blood vessels in
the liver
Submitter: C. E. Smith
RTLA 1152. Rainbow trout, Salmo gairdneri
Material: A growth severed into 2 pieces
Diagnosis: Nephroblastoma
Submitter: J. G. Hnath
RTLA 1153. Crucian carp, Carassius carassius
Material: Fixed tissue; 1 microscope slide; 2 color transparencies
Diagnosis: Nephroblastoma metastatic to pancreas
Submitter: D. Bucke
RTLA 1154. Common bream, Abramis brama
Material: Two pieces of tissue; 2 microscope slides
Diagnosis: Lymphosarcoma
Submitter: D. Bucke
RTLA 1155. Roach, Rutilus rutilus
Material: Four microscope slides; 2 paraffin blocks; 2 color
transparencies
Diagnosis: Probable thyroid adenocarcinoma
Submitter: D. Bucke
RTLA 1156. Tench, Tinea tinea
Material: Two microscope slides; 2 black and white photographs
Diagnosis: Well-differentiated rhabdomyosarcoma
Submitter: D. Bucke
RTLA 1157. Roach, Rutilus rutilus
Material: Two microscope slides; 1 paraffin block; 1 color
transparency
Diagnosis: Probable thyroid adenocarcinoma
Submitter: D. Bucke
RTLA 1158. Rainbow trout, Salmo gairdneri
Material: Two microscope slides
Diagnosis: Hepatoma
Submitter: D. Bucke
14
RTLA 1159. European eel, Anguilla anguilla
Material: One color transparency of a 8 cm lesion in ventral muscle
Diagnosis: Myositis
Submitter: D. Bucke
RTLA 1160-2. Crucian carp, Carassius carassius
Material: One microscope slide each
Diagnosis: Polycystic kidney
Submitter: D. Bucke
RTLA 1163. Rainbow smelt, Osmerus mordax
Material: One piece of tissue; 5 microscope slides; 5 electron
micrographs; 2 black and white photographs
Diagnosis: Neurilemmoma
Submitter: V. H. Logan and P. H. Odense
RTLA 1164. Sea turtle, Eretmochelys imbricate
Material: Two small growths from the corner of the right eye
Diagnosis: Inflammation associated with bacterial infection
Submitter: R. Bourke
RTLA 1165. Palani, Acanthurus dusumieri
Material: Skin from the head region of 2 palani with spreading
scale-like lesions
Diagnosis: Loss of epidermis - no inflammation - possible parasitic
etiology
Submitter: R. Bourke
RTLA 1166. Komodo dragon, Varanus komodoensis
Material: A round hard lump from a toe; 4 color transparencies;
8 microscope slides; 1 pathology record
Diagnosis: Toe - ancient encapsulated hematoma; pancreas - islet
cell tumor; colon - carcinoma; spleen - metastatic
mucinous adenocarcinoma; adrenal - pheochromocytoma;
thyroid - multiple follicular adenomas; testis -
cystic interstitial cell tumor
Submitter: C. A. Ross (toe) and R. J. Montali (other material)
RTLA 1167. Opaleye, Girella nigricans
Material: One piece of tissue; 1 microscope slide
Diagnosis: Thyroid adenoma
Submitter: R. L. Herman
RTLA 1168. Oyster, Ostrea lurida
Material: Eight pathologic microscope slides; 1 normal control
microscope slide; 3 black and white photographs
Diagnosis: Multilobed polypoid neoplasm of pericardial mesothelium
associated with a marked proliferation of connective
tissue differentiating into heart muscle
Submitter: M. C. Mix
RTLA 1169. Soft-shell clam, Mya arenaria
Material: One microscope slide
Diagnosis: Diffuse sarcoma of possible amoebocyte stem cell origin
Submitter: P. P. Yevich
A
15
RTLA 1170. Mussel, Mytilus edulis
Material: Two microscope slides; 1 black and white photograph
Diagnosis: Fibroma
Submitter: P. H. Wolf
RTLA 1171. Mud turtle, Kinosternon sub rub rum
Material: A growth from an eyelid
Diagnosis: Conjunctival epidermoid cyst
Submitter: F, Blasdell
RTLA 1172. Kahawai, Arripis trutta
Material: Testicular lesion
Diagnosis: Leiomyoma
Submitter: P. M. Hine
RTLA 1173. Rainbow trout, Salmo gairdneri
Material: One microscope slide; 5 color transparencies
Diagnosis: Multiple, minute granulomas in visceral fat due to an in¬
fectious agent, a toxin, or a sensitizing dietary by-product
Submitter: H. Wolf
RTLA 1174. Bullsnake, Pltuophis sp.
Material: Two microscope slides
Diagnosis: Intestinal polyposes/intestinal papillomatoses
Submitter: F. L. Frye
RTLA 1175. Fat-tailed gecko, Eublepharls macularis
Material: One microscope slide; 1 paraffin block
Diagnosis: Pseudocystic lesion of apparent bacterial etiology which
is associated with and may be of ovarian origin
Submitter: C. G. Crispens, Jr.
RTLA 1176. Cotton mouth moccasin, Agkistrodon piscivorus
Material: Twenty-five microscope slides
Diagnosis: Plasma cell tumor which was leukemic in the terminal phase
Submitter: E. P. Finnie
RTLA 1177. Atlantic hagfish, Myxine glutinosa
Material: Three b & w and 11 color transparencies of gross liver
tumors; 8 color photomicrographs
Diagnosis: Hepatocellular and cholanglocellular carcinomas
Submitter: S. Falkmer
Reprint: Falkmer, Sture Tumor Pathology of the Hagfish, Myxine
glutinosa, and the River Lamprey, Lampetra f luviatilis : A
Light Microscopical Study with Particular Reference to the
Occurrence of Primary Liver Carcinoma, Islet Cell Tumors, and
Epi(^ermoid Cysts of the Skin. In: Progress in Experimental Tu¬
mor Research, Vol. 20, Neoplasms in Aquatic Animals as Indi¬
cators of Environmental Carcinogens, F. Homberger (ed.), pp.
216-250. Karger: Basel. 1976.
RTLA 1178. Atlantic hagfish, Myxine glutinosa
Material: One paraffin block; 1 color photomicrograph
Diagnosis: Hepatocellular carcinoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
16
RTLA 1179. Atlantic hagfish, Myxlne glutlnosa
Material: One paraffin block; 1 color photomicrograph
Diagnosis: Cholangiocellular carcinoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1180. Atlantic hagfish, Myxine glutinosa
Material: Two paraffin blocks; 1 color photomicrograph
Diagnosis: Nodular hepatocellular hyperplasia versus adenoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1181. River lamprey, Lampetra f luviatilis
Material: Three microscope slides; 1 paraffin block; 3 color
transparencies
Diagnosis: Well-differentiated hepatocellular neoplasm
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1182. Atlantic hagfish, Myxine glutinosa
Material: One paraffin block; 1 color photomicrograph
Diagnosis: Islet tumor
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1183. Atlantic hagfish, Myxine glutinosa
Material: One piece of tissue
Diagnosis: Normal
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1184. Atlantic hagfish, Myxine glutinosa
Material: Four pieces of tissue
Diagnosis: Incipient hepatocellular neoplasm
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1185. Atlantic hagfish, Myxine glutinosa
Material: Two pieces of tissue
Diagnosis: Normal
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1186. Atlantic hagfish, Myxine glutinosa
Material: Five pieces of tissue
Diagnosis: Multiple hepatocellular neoplasms and cholangiohyperplasias
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1187. Atlantic hagfish, Myxine glutinosa
Material: Five pieces of tissue
Diagnosis: Normal
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
17
RTLA 1188. Atlantic hagfish, Myxlne glutinosa
Material; Four pieces of tissue
Diagnosis: Normal
Submitter: S. Fallmier
Reprint: (See RTLA 1177)
RTLA 1189. Atlantic hagfish, Myxlne glutinosa
Material: Three pieces of tissue
Diagnosis; Epidermoid cyst
Submitter; S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1190. Atlantic hagfish, Myxine glutinosa
Material: Three pieces of tissue
Diagnosis : Cholangioma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1191. Atlantic hagfish, Myxine glutinosa
Material; Two pieces of tissue
Diagnosis : Cholangioma
Submitter; S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1192. Atlantic hagfish, Myxine glutinosa
Material: Nine pieces of tissue
Diagnosis: Cholangiohyperplasia
Submitter: S. Falloaer
Reprint: (See RTLA 1177)
RTLA 1193. Atlantic hagfish, Myxine glutinosa
Material: Three pieces of tissue
Diagnosis: Normal
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1194. Atlantic hagfish, Myxine glutinosa
Material: Two pieces of tissue
Diagnosis: Moderately well-differentiated hepatocellular carcinoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1195. Atlantic hagfish, Myxine glutinosa
Material: Three pieces of tissue
Diagnosis: Epidermoid cyst
Submitter: S. Falkmer
Reprint: (See RTLA £177)
RTLA 1196. Atlantic hagfish, Myxine glutinosa
Material: One piece of tissue
Diagnosis; Well-differentiated hepatocellular carcinoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
18
RTLA 1197. Atlantic hagfish, Myxine glutinosa
Material: One piece of tissue
Diagnosis: Normal
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1198. Atlantic hagfish, Myxine glutinosa
Material: One piece of tissue
Diagnosis: Well-differentiated hepatocellular neoplasm; granuloma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1199. Atlantic hagfish, Myxine glutinosa
Material: One piece of tissue
Diagnosis: Well-differentiated hepatocellular neoplasm
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1200. Atlantic hagfish, Myxine glutinosa
Material: Four pieces of tissue
Diagnosis: Cholangioma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1201. Atlantic hagfish, Myxine glutinosa
Material: One gross specimen
Diagnosis: Normal
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1202. Atlantic hagfish, Myxine glutinosa
Material: One gross specimen
Diagnosis: Multiple nodular well-differentiated hepatocellular
neoplasm
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1203. Atlantic hagfish, Myxine glutinosa
Material: One gross specimen
Diagnosis: Hemorrhage
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1204. English sole, Parophrys vetulus
Material: A wedge of body wall and attached dorsal fin with a
growth involving both the pigmented and unpigmented sides
of the fish and dorsal fin
Diagnosis: A large, ulcerated, excavating, inflammatory lesion
involving the dermis, subcutaneous connective tissue,
and skeletal muscle in response to two types of meta¬
zoan parasites
G. R. Bell
Submitter :
19
RTLA 1205. Rainbow trout, Salmo gairdneri
Material: Enlarged kidney, spleen, liver, and heart tissue
Diagnosis: Probable lymphoma
Submitter: P. M. Hine
RTLA 1206. Helmeted turtle, Pelomedusa subruta
Material: Three microscope slides; 1 laboratory report
Diagnosis: Myelogenous leukemia
Submitter: R. J. Montali
RTLA 1207. Toad, Pipa pipa
Material: One gross specimen
Diagnosis: Infestation by helminths; cause of death undetermined
Submitter: I. L. C. Gorman
RTLA 1208. Coris f lavovittata
Material: Right gill arch with attached growth
Diagnosis: Thyroid adenoma
Submitter: R. Bourke
RTLA 1209. Lake trout, Salvelinus namaycush
Material: A piece of tissue from a growth attached to the
exterior body wall
Diagnosis: Well-differentiated lipoma
Submitter: G. R. Bell
RTLA 1210. Atlantic salmon, Salmo salar
Material: Liver and gall bladder with 2 cyst-like growths; 1
microscope slide; 1 black and white photograph
Diagnosis: Pseudocysts of possible parasitic origin in the liver
Submitter: C. E. Smith
RTLA 1211A & B.
Material :
Diagnosis :
Submitter :
Milkfish, Chanos chanos
Normal adipose eyelid (RTLA 1211A) ; ■ opaque adipose
eyelid (RTLA 1211B)
Severe pigmentation and opaqueness of eyelid
A. C. Smith
RTLA 1212A & B.
Material:
Diagnosis :
Submitter :
Albula vulpes
Opaque adipose eyelid (RTLA 1212A) ; normal adipose
eyelid (RTLA 1212B)
Mild pigmentation and opaqueness of eyelid
A. C. Smith
RTLA 1213A & B.
Material :
Diagnosis :
Submitter :
Tilapia mossamblca
"Anemic" liver tissue (RTLA 1213A) ; normal liver
tissue (RTLA 1213B)
Postmortem change
A. C. Smith
RTLA 1214. Ceylonese pond frog, Rana hexadactylus
Material: One gross specimen
Diagnosis: A massive disseminated infection by a septate spore¬
forming fungus
Submitter: G. C. Blasiola, Jr.
20
RTLA 1215. Rat snake, Elaphe obsoleta
Material: One gross specimen
Diagnosis: Cause of death undetermined
Submitter: I. L. C. Gorman
RTLA 1216. Rat snake, Elaphe obsoleta
Material: One gross specimen
Diagnosis: Acanthocephalan worm and bacteria in lungs; pneumonia
Submitter: I. L. C. Gorman
RTLA 1217. Rock sole, Lepidopsetta billneata
Material: A piece of body wall with attached growth
Diagnosis: Epidermal papilloma associated with dermal parasitic
granulomas
Submitter: G. R. Bell
RTLA 1218. Lingcod, Ophiodon elongatus
Material: A large piece of body wall
Diagnosis: Lymphocystis
Submitter: G. R. Bell and G. E. Hoskins
RTLA 1219. Golden trout, Salmo aguabonita
Material: Two pieces of tissue; 4 microscope slides; 2 color trans¬
parencies; 2 black and white photographs
Diagnosis: Renal versus thyroid adenocarcinoma
Submitter: C. E. Smith
RTLA 1220. Striped bass, Morone saxatilis
Material: Viscera with attached growth
Diagnosis: Probable leiomyoma; inadequately preserved for a
definitive diagnosis
Submitter: M. W. Smith
RTLA 1221. Spiny dogfish, Squalus acanthias
Material :
Diagnosis :
Submitter :
Reprint :
Seven microscope slides; 1 paraffin block; 39 color
transparencies; 83 b & w photographs; 7, 4X5" &
5, 35 mm b & w negatives
A choroid plexus papilloma
A. M. Guarino and D. J. Prieur
Prieur, David J. , Joseph D. Fenstermacher , and Anthony M.
Guarino. A Choroid Plexus Papilloma in an Elasmobranch,
Squalus acanthias. J. Natl. Cancer Inst., 1207-09. 1976.
RTLA 1222. White perch, Morone americana
Material: One microscope slide; 1 color transparency
Diagnosis: Well-vascularized, ulcerated, fibrous hyperplasia of the
dermis associated with inflammation
Submitter: T. Beckerman and R. P. Morgan, II
RTLA 1223. Guppy, Poecllia reticulata
Material: Two microscope slides
Diagnosis: (1) Multiple visceral and body wall granulomas; (2) cholan-
gioma in liver
Submitter: G. E. Cosgrove
21
RTLA 1224. Spot, Leiostomus xanthurus
Material: Three microscope slides from 3 fish; 1 color photograph
Diagnosis: (1) Thyroid hyperplasia in all fish; (2) gill hyperplasia
in one fish
Submitter: G. E. Cosgrove
RTLA 1225. White perch. Mo rone americana
Material: Two microscope slides; 2 color transparencies
Diagnosis: Bile duct adenof ibrosis of probable hepatotoxin origin
Submitter: T. Beckerman and R. P. Morgan, II
RTLA 1226. Tiger salamander, Amby stoma tigrinum
Material: Viscera; internal growth just anterior to the stomach
Diagnosis: Metastatic pancreatic carcinoma
Submitter: F. L. Rose
RTLA 1227. Surf clam, Spisula solidissima
Material: A portion of the foot with attached growth; 2 color
transparencies; 1 black and white photograph
Diagnosis: Multiple polypoid myomas of the foot
Submitter: L. Leibovitz
RTLA 1228. Oyster, Crassostrea virginica
Material: A growth with adjacent tissue
Diagnosis: Polypoid vesicular tumor and associated inflammation
Submitter: S. V. Otto
RTLA 1229. American alligator. Alligator misslssippiensis
Material: Growth from anterior to left nares
Diagnosis: Pending
Submitter: C. A. Ross
RTLA 1230. Panamint rattlesnake, Crotalus mltchelli
Material: Four microscope slides; 2 paraffin blocks
Diagnosis: Multiple subcutaneous mycotic granulomas
Submitter: G. G. Grispens, Jr.
RTLA 1231. Striped bass, Morone saxatilis
Material: Three microscope slides; 4 color transparencies
Diagnosis: Infectious granulomas in liver and spleen
Submitter: T. Beckerman and R. P. Morgan, II
RTLA 1232A & B.
Material :
Diagnosis :
Submitter :
Milkfish, Chanos chanos
Four pieces of stomach tissue — 2 pathologic; 2 normal
Gastritis
A. G. Smith
RTLA 1233. Grevalle jack, Caranx hippos
Material: Seventeen microscope slides
Diagnosis: Fibroma
Submitter: F. J. Schwartz
Reprint: Schwartz, Frank J. A Grevalle Jack, Caranx hippos (Pisces.
Carangldae) , With Mandibular Calcified Connective Tissue
Fibroma. Chesapeake Sci., ]^(1) : 72-3. 1975.
22
RTLA 1234. White perch, Morone americana
Material: One microscope slide; 5 color transparencies
Diagnosis: Bile duct adenof ibrosis associated with a protozoan
infection
Submitter: T. Beckerman and R. P. Morgan, II
RTLA 1235. Carp, Cyprinus carpio (?)
Material: One microscope slide
Diagnosis: Focal spermatocytoma/early seminoma
Submitter: D. Bucke
RTLA 1236. Siganus rivulatus
Material: Two pieces of liver tissue; 3 microscope slides
Diagnosis: Probable cholangiof ibrosis
Submitter: I. Paperna
RTLA 1237. Sea bream, Sparus auratus
Material: One microscope slide; epon embedded tissue
Diagnosis: Extracellular inclusions (cores of granulomas) in
the gills
Submitter: I. Paperna
RTLA 1238. Eastern box turtle, Terrapene Carolina
Material: One gross specimen (alive) with 2 greatly enlarged
areas involving both sides of the head, posterior
to the eyes; the jaws were misaligned by the swelling
Diagnosis: Mastoid granuloma
Submitter: R. Eschelman
RTLA 1239. Eastern box turtle, Terrapene Carolina
Material: A growth removed from the right side of the head
near the ear
Diagnosis: Bacterial granuloma
Submitter: W. Frair
RTLA 1240. Dover sole. Micros tomus pacificus
Material: Dorsal fin with small yellow nodules; 1 microscope
slide
Diagnosis: Possibly some type of fat storage disease
Submitter: G. E. Hoskins and G. R. Bell
RTLA 1241. American crocodile, Crocodylus acutus
Material: One microscope slide; 1 color transparency; 1
pathology record
Diagnosis: Lipoma versus some type of fat storage disease
Submitter: R. J. Montali
RTLA 1242. Boa constrictor
Material: One microscope slide; 2 color transparencies; 1
necrospy record
Diagnosis: Renal adenocarcinoma
Submitter: R. J. Montali
23
RTLA 1243. Atlantic cutlassfish, Trichiurus lepturus
Material: A piece of body wall with growth around the vent
Diagnosis: Ulcerated, excavating (muscle), inflammatory lesion
mostly composed of fibrocytes, a mixed population of
leukocytes, and a large population of several species
of bacteria; some type of worm was also present
Submitter: D. J. Ebert
RTLA 1244. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Moderately well-differentiated hepatocellular neoplasm
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1245. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Hepatocellular and cholangiocellular — mixed carcinoma
"adenoma" and hamartoma (?)
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1246. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Hepatocellular and cholangiocellular - adenoma (?)
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1247. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Hepatocellular and cholangiocellular - hepatocellular
carcinoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1248. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Hepatocellular and cholangiocellular - bleedings
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1249. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 2 paraffin blocks
Diagnosis: Hepatocellular and cholangiocellular - adenoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1250. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 2 paraffin blocks
Diagnosis: Hepatocellular and cholangiocellular - cholangiocellular
carcinoma + nodular hyperplasia (?)
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
24
RTLA 1251. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 3 paraffin blocks
Diagnosis: Hepatocellular and cholangiocellular - cholangiocellular
carcinoma + nodular hyperplasia
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1252. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Hepatocellular and cholangiocellular - cholangiocellular
carcinoma + nodular hyperplasia
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1253. Atlantic hagfish, Myxine glutinosa
Material: Three microscope slides
Diagnosis: Hamartoma (?) - insuloma-hamartoma (cyst only)
Submitter: S. Falkmer *
Reprint: (See RTLA 1177)
RTLA 1254. Atlantic hagfish, Myxine glutinosa
Material: Three microscope slides; 1 paraffin block
Diagnosis: Hamartoma (?) - insuloma-hamartoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1255. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Hamartoma (?) - insuloma-hamartoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1256. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Hamartoma (?) - poorly-differentiated Insuloma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1258. Atlantic hagfish, Myxine glutinosa
Material: Three microscope slides; 1 paraffin block
Diagnosis: Hamartoma (?) - highly-differentiated insuloma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1259. Atlantic hagfish, Myxine glutinosa
Material: Two microscope slides; 2 paraffin blocks
Diagnosis: Adenocarcinoma - solid tumor - mucus granuloma (?)
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1260. Atlantic hagfish, Myxine glutinosa
Material: Two microscope slides; 1 paraffin block
Diagnosis: Adenocarcinoma - solid tumor
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
25
RTLA 1261. Atlantic hagflsh, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Cutaneous leiomyosarcoma - fibroma (?)
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
sarcoma
RTLA 1262. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide
Diagnosis: Cutaneous leiomyosarcoma - leiomyosarcoma
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1263. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Cutaneous leiomyosarcoma - sessile skin polyp, con¬
taining ganglion cells (?) myelomeningocoele (?) "myxoma'
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1264. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide
Diagnosis: Cutaneous leiomyosarcoma - fibroma of the tentacles
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1265. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide
Diagnosis: Non-neoplastic cysts
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1266. Atlantic hagfish, Myxine glutinosa
Material: One microscope slide; 1 paraffin block
Diagnosis: Non-neoplastic cysts
Submitter: S. Falkmer
Reprint: (See RTLA 1177)
RTLA 1267. Shortfin eel, Anguilla australis
Material: Fixed material; 2 black and white photographs
Diagnosis: Hepatoma
Submitter: P. M. Hine
RTLA 1268A & B.
Material:
Diagnosis :
Submitter:
American lobster, Homarus americanus
Normal and abnormal structures from diseased animal
(RTLA 1268A) ; same structures from control animal
(RTLA 1268B)
Developing egg masses that adhered to the appendages
and coxa during spawning
S. A. MacLean
RTLA 1269. Chinook salmon, Oncorhynchus tschawytscha
Material: Piece of body wall with a large, black, granular growth
Diagnosis: Melanoma
Submitter: J. G. Hnath
26
RTLA 1270. Pseudo tropheus tropheops
Material: Gross specimen with a growth on the body wall
Diagnosis: Neurilemmal sarcoma
Submitter: G. C. Blasiola, Jr.
RTLA 1271. Hard-shell clam, Mercenaria mercenaria
Material: One paraffin block
Diagnosis: Intracellular inclusions
Submitter: S, V. Otto
RTLA 1272. Mussel, Modiolus modiolus
Material: Four microscope slides
Diagnosis: Benign neoplasm of vesicular connective tissue
Submitter: R. J. Roberts
RTLA 1273. Coho salmon, Oncorhynchus kisutch
Material: One gross specimen with a large growth on the left side
Diagnosis: Nephroblastoma
Submitter: G. E. Hoskins and G. R. Bell
RTLA 1274-1374.
Material:
Diagnosis :
Submitter :
Soft-shell clam. My a arenaria
One hundred twenty-five microscope slides; 211 paraffin
blocks
Approximately one-third of the cases have been examined;
all are germinomas
P. P. Yevich
RTLA 1375. Creek chub, Semotilus atromaculatus
Material: One gross specimen with 4 lesions: 1 under the right
lower jaw; 1 on the left lateral body wall, posterior
to the vent; 1 on the left peduncle; and 1 internally
(mid-ventral) attached to the body wall
Diagnosis: Protozoan cyst, Myxobolus sp. suspected
Submitter: W. J. Buc
RTLA 1376. Brown bullhead, Ictalurus nebulosus
Material: Four microscope slides
Diagnosis: Oral epidermal papilloma
Submitter: K. E. Wolf and E. J. Washuta
RTLA 1377. Chinook salmon, Oncorhynchus tshawytscha
Material: A large piece of body wall; 4 color photographs
Diagnosis: Partial reduplication of the digestive tract; develop¬
mental anomaly
Submitter: J. G. Hnath
RTLA 1378. Snapper
Material: Nineteen microscope slides
Diagnosis: Neurilemmoma
Submitter: M. M. Sigel
27
RTLA 1379. Honey bee, Apis mellif era
Material: Twenty microscope slides
Diagnosis: The following bacterial and mycotic (fungal) diseases,
protozoan and gregarine infections, mites, and louses
are represented:
American foulbrood - Bacillus larvae
European foulbrood - Streptococcus pluton ;
Bacillus laterosporus (probable secondary
invader)
Septicemia - Pseudomonas (Bacillus) apiseptica
Stonebrood - Aspergillus flavus
Chalkbrood - Ascosphaera apis
Nosema apis
Monocia apis
Varroa jacobsoni
Tropilaelaps clareae
Braula coeca
Submitter: G. E. Cantwell
Reprint: Cantwell, George E. Honey Bee Diseases, Parasites, and
Pests. In: Insect Diseases, Vol. 2, G. E. Cantwell
(ed.), pp. 501-47. Marcel Dekker: New York. 1974.
RTLA 1380. Gulf coast box turtle, Terrapene Carolina major
Material: Two microscope slides; 1 paraffin block
Diagnosis: Infectious granuloma of mixed bacterial etiology
Submitter: C. G. Crispens, Jr. and K. R. Marion
RTLA 1381. Soft-shell clam, Mya arenaria
Material: One paraffin block
Diagnosis: Teratoid anomaly
Submitter: S. V. Otto
RTLA 1382. Rainbow trout, Salmo gairdneri
Material: One microscope slide
Diagnosis: Adenocarcinoma
Submitter: B. L. Munday
RTLA 1383. "Fancy" carp (Nishikigoi) , Cyprinus sp.
Material: Forty-five microscope slides representing six cases
Diagnosis: Ovarian teratoid tumors
Submitter: T. Ishikawa
28
INDEX OF NEOPLASM - ANIMAL GROUP - AND RTLA NUMBER
Adenoma/Adenocarcinoma: Reptile - 1166 (colon, thyroid), 1242 (renal);
Amphibian - 1226 (pancreas); Fish - 1079 (pseudobranch), 1099-1103
(thyroid), 1109 (origin undetermined), 1155, 1157, 1167, 1208, 1219
(thyroid), 1382 (origin undetermined); Jawless fish - 1259-60
Anitschkow myocyte tumor: Reptile - 1115
Cholangiocellular neoplasms: lawless fish - 1177, 1179, 1190-2, 1200, 1223
1245-52
Chondrof ibroma/Chondromyxoma: Amphibian - 1080; Fish - 1113
Choroid plexus papilloma: Cartilaginous fish - 1221
Epidermal papillomas: Fish - 1082-4, 1086, 1376
Fibroma/Fibrosarcoma/Fibromyxoma : Amphibian - 1133; Fish 1090, 1094, 1111,
1233; Mollusk - 1170
Germinoma: Mollusk - 1274-1374
Hemangioendothelioma: Fish - 1151
Hematopoietic neoplasms: Reptile - 1176, 1206; Fish - 1154, 1205; Mollusk
1117, 1169
Hepatocellular neoplasms: Fish - 1158, 1267; Jawless fish - 1177-8, 1180-1
1184, 1186, 1194, 1196, 1198-9, 1202, 1244-52
Insuloma: Jawless fish - 1253-7
Intestinal polyposis: Reptile - 1174
Islet tumor: Reptile - 1166; Fish - 1182
Leiomyoma/Leiomyosarcoma: Fish - 1172, 1220; Jawless fish - 1261-4
Lipoma: Reptile - 1241; Fish - 1209
Melanoma: Fish - 1269
Myoma/Myoblastoma: Fish - 1087; Mollusk - 1168, 1227
Nephroblastoma: Fish - 1124, 1152-3, 1273
Neurilemmoma/Neurofibroma: Fish - 1078, 1091, 1163, 1270, 1378
Neuroblastoma: Amphibian - 1135
Osteoma: Fish 1149
Rhabdomyosarcoma: Fish - 1156
29
Seminoma: Fish - 1235
Teratoid ovarian neoplasm: Fish - 1383
Vesicular connective tissue tumor: Mollusk - 1228, 1272
30
PHYLOGENETIC INDEX
PHYLUM CHORDATA
Class Reptilia
Order Chelonia (turtles) - RTLA 1150, 1164, 1171, 1206, 1238, 1239
Order Squamata (lizards, snakes) - RTLA 1093, 1107, 1114-16, 1131,
1147, 1166, 1174-76, 1215, 1216, 1230, 1242
Order Loricata (alligators, crocodiles) - RTLA 1229, 1241
Class Amphibia
Order Caudata (salamanders, newts) - RTLA 1133, 1135, 1226
Order Anura (toads, frogs) - RTLA 1080, 1132, 1207, 1214
Class Osteichthyes
Order Salmoniformes
Family Salmonidae (salmon, trout, whitefish) - RTLA 1090, 1119,
1120, 1149, 1151, 1152, 1158, 1173, 1205, 1209, 1210, 1219,
1269, 1273, 1377
Family Osmeridae (smelts) - RTLA 1163
Order Perciformes
Family Percidae (perches) - RTLA 1136-46
Family Carangidae (jacks, pompanos) - RTLA 1233
Family Sciaenidae (drums, croakers) - RTLA 1086, 1095, 1224
Family Lutjanldae (snappers) - RTLA 1378
Family Scorpaenldae (scorpionf ish, rockfish) - RTLA 1079
Family Cottidae (sculpins) - RTLA 1078
Family Embiotocidae (surfperches) - RTLA 1085
Family Mugilidae (mullets) - RTLA 1096, 1111
Family Acanthuridae (surgeonf ishes) - RTLA 1165
Family Kyphosidae (sea chubs) - RTLA 1167
Family Arripidae - RTLA 1172
Family Hexagrammidae - RTLA 1218
- 31
Family Percichthyidae (temperate basses) - RTLA 1123, 1124,
1220, 1222, 1225, 1231, 1234
Family Trichiurldae (cutlassf Ishes) - RTLA 1243
Family Clchlldae (clchlids) - RTLA 1270
Family Sparldae - RTLA 1237
Order Cyprinlformes (suckers, roaches, goldfish, carps, scissors-
tail) - RTLA 1087, 1091, 1094, 1109, 1153-57, 1160-62, 1235, 1375
Order Siluriformes (catfish) - RTLA 1113, 1376
Order Pleuronectiformes (sole, flounders, sanddabs) - RTLA 1081-84,
1112, 1121, 1204, 1217, 1240
Order Atheriniformes (killifish, platys, needlefish, mollies, top
minnows) - RTLA 1099-1103, 1105, 1223
Order Anguilliformes (eels) - RTLA 1108, 1110, 1159, 1267
Order Acipenseriformes (sturgeons) - RTLA 1118
Order Clupeiformes (herrings, menhaden) - RTLA 1097, 1098
Not classified - RTLA 1208, 1211-1213, 1232, 1236
Class Chondrichthyes
Order Squaliformes (sharks) - RTLA 1221
Class Agnatha
Order Myxiniformes (hagfishes) - RTLA 1177-80, 1182-1203, 1244-66
Order Petromyzontif ormes (lampreys) - RTLA 1181
SUBPHYLUM TUNICATA
RTLA 1106
PHYLUM ECHINODERMATA
Class Echinoldea (sea urchins) - RTLA 1104
PHYLUM MOLLUSC A
Class Bivalvla (mussels, clams, scallops, oysters) - RTLA 1088, 1089,
1092, 1117, 1125-30, 1148, 1168-70, 1227, 1228, 1271, 1272, 1274-1374
PHYLUM ARTHROPODA
Subclass Copepoda (copepods) - RTLA 1122
- 32 -
Subclass Malacostraca
Order Decapoda (shrimp, lobster) - RTLA 1134, 1268
- 33
INDEX OF SPECIMENS BY SCIENTIFIC AND COMMON NAMES
RTLA NO.
Abramis brama
Acanthurus dusumieri
Aclpenser oxyrhynchus
Agklstrodon plscivorus
Albula vulpes
Alligator mlssissippiensis
Amazon molly
Amby stoma tlgrinum
American alligator
American crocodile
American lobster
American toad
Anguilla angullla
Anguilla australis
Apis mellifera
Arius f elis
Arripis trutta
Ascidiella sp.
Atlantic cutlassfish
Atlantic hagfish
Atlantic salmon
Atlantic sturgeon
1154
1165
1118
1176
1212A & B
1229
1099-1103, 1105
1226, 1133
1229
1241
1268A & B
1132
1159
1108, 1110, 1267
1379
1113
1172
1106
1243
1177-1180, 1182-1203, 1244-1256,
1258-1266
1210
1118
Boa constrictor 1114-1116, 1131, 1242
Brevoortia sp.
1097, 1098
Brown trout
1090
Bufo americanus
1132
Bullhead
1376
Bullsnake
1174
C
Caranx hippos
1233
Carassius auratus
1091
Carassius carassius
1153,
1160-1162
Carp
1094,
1235
Catostomus macrocheilus
1087
Ceylonese pond frog
1214
Chanos chanos
1211A
& B, 1232A
Chinook salmon
1120,
1269, 1377
Chrysemys ornata callirostris
1150
Chum salmon
1149
Citharichthys stigmaeus
1081
Coho salmon
1119,
1273
- 34
RTLA NO.
Common bream
1154
Copepod
1122
Coris flavovittata
1208
Corn snake
1107
Cotton mouth moccasin
1176
Cottus gobio
1078
Crassostrea commercialis
1117
Crassostrea virginica
1125,
1126,
Creek chub
1375
Crevalle jack
1233
Croaker
1095
Crocodylus acutus
1241
Crotalus mitchelli
1230
Crucian carp
1153,
1160-
Cyprinus carpio
D
Dover sole
1094,
1235
1082-1084,
Eastern box turtle
1238,
1239
Elaphe guttata guttata
1107
Elaphe obsoleta
1215,
1216
Elaphe obsoleta quadrivittata
1147
English sole
1204
Eretmochelys imbricata
1164
Eublepharis macularis
1175
European eel
17
1159
r
Fat-tailed gecko
n
1175
Kj
Genyonemus lineatus
1086
Geoduck
1148
Gigantocypris muelleri
1134
Girella nigricans
1167
Golden trout
1219
Goldfish
1091
Gulf coast box turtle
1380
Guppy
1223
H
Hard-shell clam
1092,
1271
Helmeted turtle
1206
Homarus americanus
1268A
& B
Honey bee
1379
Hyla regilla
1080
- 35
RTLA NO.
Ictalurus sp. 1376
K
Kahawai 1172
Kinosternon sub rub rum 1171
Komodo dragon 1166
L
Lake trout 1151, 1209
Lampetra f luvlatllis 1181
Largescale sucker 1087
Lelostomus xanthurus 1224
Lepidopsetta bilineata 1217
Lernaeenlcus radiatus 1122
Lingcod 1218
M
Menhaden
Mercenarla mercenaria
Microstomus pacif icus
Milkf ish
Modiolus modiolus
Morone americana
Morone saxatills
Mud turtle
Mug 11 cephalus
Mussel
Mussel shrimp
My a arenarla
Mytllus edulls
Myxlne glutlnosa
N
1097, 1098
1092, 1271
1240, 1082-1084
1211A & B, 1232A & B
1272
1222, 1225, 1234
1123, 1124, 1220, 1231
1171
1096, 1111
1088, 1089, 1170, 1272
1134
1127-1130, 1169, 1274-1374, 1381
1088, 1089, 1170
1177-1180, 1182-1203, 1244-1266
Notophthalmus vlrldescens 1135
0
Oncorhynchus keta
Oncorhynchus klsutch
Oncorhynchus tschawytscha
Opaleye
Ophlodon elongatus
Osmerus mordax
Ostrea lurlda
Oyster
1149
1119, 1273
1120, 1269, 1377
1167
1218
1163
1168
1125,
1126, 1168, 1228
36
RTLA NO.
Pacific tree frog
Palani
Panamint rattlesnake
Panope generosa
Paralichthys dentatus
Paralichthys lethostigma
Parophrys vetulus
Pelomedusa subruta
Phanerodon furcatus
Pipa pipa
Pituophis sp.
Poecilia formosa
Poecilia reticulata
Pseudo tropheus tropheops
R
1080
1165
1230
1148
1121
1112
1204
1206
1085
1207
1174
1099-1103, 1105
1223
1270
Rainbow smelt
Rainbow trout
Rana hexadactylus
Rasbora trilineata
Rat snake
Red-spotted newt
River lamprey
Roach
Rockf ish
Rock sole
Rutilus rutilus
1163
1152, 1158, 1173, 1205, 1382
1214
1109
1215, 1216
1135
1181
1155, 1157
1079
1217
1155, 1157
S
Salmo aguabonita
Salmo gairdneri
Salmo salar
Salmo trutta
Salvellnus namaycush
Scissorstail
Sculpin
Sea bream
Sea catfish
Sea turtle
Sea urchin
Sebastes sp.
Semotilus atromaculatus
Shortfin eel
Slganus rivulatus
Sitana ponticeriana
Snapper
Soft-shell clam
1219
1152, 1158, 1173, 1205, 1382
1210
1090
1151, 1209
1109
1078
1237
1113
1164
1104
1079
1375
1108, 1110, 1267
1236
1093
1378
1127-1130, 1169, 1274-1374, 1381
37
RTLA NO.
Southern flounder
1112
Sparus auratus
1237
Speckled sanddab
1081
Spiny dogfish
1221
Spisula solidissima
1227
Spot
1224
Squalus acanthias
1221
Striped bass
1123, 1124
Striped mullet
1096, 1111
Stizostedion vitreum vitreum
1136-1146
Summer flounder
1121
Surf clam
1227
Sydney rock oyster
1117
T
Tench
1156
Terrapene Carolina
1238, 1239
Terrapene Carolina major
1380
Tiger salamander
1133, 1226
Tilapia mossambica
1213A & B
Tinea tinea
1156
Toad
1207
Trichiurus lepturus
1243
Tropical red-eared turtle
1150
Tunicate
1106
V
Varanus komodoensis
1166
W
Walleye
1136-1146
White croaker
1085
White perch
1222, 1225
White seaperch
1085
Y
Yellow rat snake
1147
1220, 1231
1234
38
CONTRIBUTORS
BECKER, C. D.
Ecosystems Department
Battelle Pacific Northwest
Laboratories
Battelle Boulevard
Richland, Washington 99352
RTLA 1087
BECKERMAN, T.
Chesapeake Biological
Laboratory
Solomons, Maryland 20688
RTLA 1222, 1225, 1231, 1234
BELL, G. R.
Pacific Biological Station
Fisheries and Marine Service
Department of the Environment
P. 0. Box 100
Nanaimo, B.C., Canada V9R 5K6
RTLA 1149, 1204, 1209, 1217,
1218, 1240, 1273
BLASDELL, F.
Division of Amphibians and
Reptiles
National Museum of Natural History
Smithsonian Institution
Washington, D.C. 20560
RTLA 1171
BLASIOLA, G. C. , JR.
Steinhart Aquarium Laboratory
California Academy of Sciences
Golden Gate Park
San Francisco, California 94118
RTLA 1109, 1214, 1270
BOURKE, R.
Hawaiian Reef Tank
Sea Life, Inc.
Makapuu Point
Waimanalo, Hawaii 96795
RTLA 1164, 1165, 1208
BOUSTEAD, N. C.
Fisheries Research Division
Ministry of Agriculture and Fisheries
P. 0. Box 19062
Wellington, New Zealand
RTLA 1110
BUC, W. J.
Grayling Field Office
Michigan Department of Natural Resources
P. 0. Box 507
Grayling, Michigan 49738
RTLA 1375
BUCKE, D.
20 Queens Close
St. Ives, Cambridgeshire
England
RTLA 1153-1162, 1235
CANTWELL, G. E.
Insect Pathology Laboratory
Plant Protection Institute
Agricultural Research Service
U.S. Department of Agriculture
Beltsville, Maryland 20705
RTLA 1379
CHAMBERLAIN, D. W.
Atlantic Richfield Company
515 South Flower Street
Los Angeles, California 90047
RTLA 1081-1086
CHANG, S. C.
Registry of Tumors in Lower Animals
National Museum of Natural History
Smithsonian Institution
Washington, D.C. 20560
RTLA 1092
COSGROVE, G. E.
Biology Division
Oak Ridge National Laboratory
P. 0. Box Y
Oak Ridge, Tennessee 37831
RTLA 1223, 1224
COUNTS, C. L., Ill
Department of Biological Sciences
Marshall University
Huntington, West Virginia 25701
RTLA 1132, 1135
CRISPENS, C. G., JR.
Department of Biology
The University of Alabama in Birmingham
University Station
Birmingham, Alabama 35294
RTLA 1107, 1131, 1175, 1230, 1380
39
DOWNEY, M. E.
Division of Echinoderms
National Museum of Natural History
Smithsonian Institution
Washington, D.C. 20560
RTLA 1104
EBERT, D. J.
Department of Biology
SS Box 18
University of Southern
Mississippi
Hattiesburg, Mississippi 39401
RTLA 1243
ECONOMON, P. P.
Minnesota Department of
Natural Resources
390 Centennial Office Building
St. Paul, Minnesota 55155
RTLA 1136-1146
ELKAN, E.
Department of Histopathology
Mount Vernon Hospital
Northwood, Middlesex HA6 2RN
England
RTLA 1114-1116, 1150
ESCHELMAN, R.
Calvert Marine Museum
Solomons, Maryland 20688
RTLA 1238
FALKMER, S.
Institute of Pathology
University of Umea
S901 87 Umea 6, Sweden
RTLA 1177-1203, 1244-1266
FINNIE, E. P.
Taronga Zoo
P. 0. Box 20
Mosman, New South Wales
Australia 2088
RTLA 1176
FRAIR, W.
The King's College
Briarcliff Manor, New York 10510
RTLA 1239
FRYE, F. L.
235 Willamette Avenue
Kensington, California 94708
RTLA 1080, 1174
GORMAN, I. L. C.
Sharkey-S impson
1500-1502 West Santa Barbara Avenue
Los Angeles, California 90062
RTLA 1147, 1207, 1215, 1216
GUARINO, A. M.
Mt. Desert Island Biological Laboratory
Salsbury Cove, Maine 04672
RTLA 1221
HARSHBARGER, J. C.
Registry of Tumors in Lower Animals
National Museum of Natural History
Smithsonian Institution
Washington, D.C. 20560
RTLA 1092
HART, R. W.
The College of Medicine Facilities
The Ohio State University Hospitals
410 West 10th Avenue
Columbus, Ohio 43210
RTLA 1099-1103, 1105
HERMAN, R. L.
Eastern Fish Disease Laboratory
U.S. Department of the Interior
Leetown, Route 1, Box 17A
Kearneysville , West Virginia 25430
RTLA 1167
HINE, P. M.
Fisheries Research Division
Ministry of Agriculture and Fisheries
P. 0. Box 19062
Wellington, New Zealand
RTLA 1090, 1108, 1110, 1172, 1205, 1267
HNATH, J. G.
Wolf Lake Pathobiology Laboratory
Wolf Lake Hatchery
Michigan Department of Natural Resources
Route 1
Mattawan, Michigan 49071
RTLA 1152, 1269, 1377
HOSKINS, G. E.
Pacific Biological Station
Fisheries and Marine Service
Department of the Environment
P. 0. Box 100
Nanaimo, B.C., Canada V9R 5K6
RTLA 1079, 1218, 1240, 1273
- 40 -
ISHIKAWA, T.
Cancer Institute
Kami-Ikebukuro, Toshima-ku
Tokyo 170, Japan
RTLA 1383
KANDRASHOFF, W.
951 Euclid Avenue
Miami Beach, Florida 33139
RTLA 1095-1098
KORNICKER, L. S.
Division of Crustacea
National Museum of Natural History
Smithsonian Institution
Washington, D.C. 20560
RTLA 1134
LAIRD, L. M.
Department of Zoology
The University of Liverpool
Brownlow Street
P. 0. Box 147
Liverpool L69 3BX, England
RTLA 1106
LEIBOVITZ, L.
Department of Avian and Aquatic
Animal Medicine
New York State Veterinary College
Cornell University
Ithaca, New York 14853
RTLA 1227
LOGAN, V. H.
Halifax Laboratory
Fisheries and Marine Service
Department of the Environment
P, 0. Box 429
Halifax, N.S., Canada B3J 2R3
RTLA 1163
MACLEAN, S. A.
Pathobiology Investigations
Middle Atlantic Coastal Fisheries
Center, NMFS, NOAA
U.S. Department of Commerce
Oxford, Maryland 21654
RTLA 1268A & B
MARION, K. R.
Department of Biology
The University of Alabama in
Birmingham
University Station
Birmingham, Alabama 35294
RTLA 1380
MATZ, G.
Laboratoire de Biologle Anlmale
Faculte des Sciences
Universite d ’Angers
Avenue Lavoisier — Belle-Beille
49045 Angers Cedex, France
RTLA 1093
MEYERS, T. R.
Shelter Valley Road
R.D. 3, Lot 30
Newfield, New York 14867
RTLA 1118-1122
MIGAKI, G.
Division of Gomparative Pathology
The American Registry of Pathology
Armed Forces Institute of Pathology
Washington, D.G. 20306
RTLA 1094
MIX, M. G.
Department of General Science
Oregon State University
Gorvallis, Oregon 97331
RTLA 1168
MONTALI, R. J.
Office of Pathology
National Zoological Park
Smithsonian Institution
Washington, D.G. 20009
RTLA 1166, 1206, 1241, 1242
MORGAN, R. P., II
Chesapeake Biological Laboratory
Solomons, Maryland 20688
RTLA 1222, 1225, 1231, 1234
MONDAY, B. L.
Mt. Pleasant Laboratories
Department of Agriculture
Box 46, Launceston South
Tasmania, Australia 7250
RTLA 1382
ODENSE, P. H.
Halifax Laboratory
Fisheries and Marine Service
Department of the Environment
P. 0. Box 429
Halifax, N.S., Canada B3J 2R3
RTLA 1163
- 41
OTTO, S. V.
Maryland Department of Natural
Resources
c/o Middle Atlantic Coastal
Fisheries Center, NMFS, NOAA
U.S. Department of Commerce
Oxford, Maryland 21654
RTLA 1092, 1125-1130, 1228,
1271, 1381
OVERSTREET, R. M.
Parasitology Section
Gulf Coast Research Laboratory
P. 0. Drawer AG
Ocean Springs, Mississippi 39564
RTLA 1111-1113
PAPERNA, 1.
The Heinz Steinitz Marine
Biology Laboratory
The Hebrew University of
Jerusalem
P. 0. Box 469
Eilat, Israel
RTLA 1236, 1237
PRIEUR, D. J.
Department of Veterinary Pathology
Washington State University
Pullman, Washington 99163
RTLA 1221
ROBERTS, R. J.
Unit of Aquatic Pathobiology
University of Stirling
Stirling FK9 4LA, Scotland
RTLA 1091, 1272
ROSE, F. L.
Department of Biology
Texas Tech University
P. 0. Box 4149
Lubbock, Texas 79409
RTLA 1133, 1226
ROSS, C. A.
Department of Natural Science
The Florida State Museum
University of Florida
Gainesville, Florida 32611
RTLA 1166, 1229
SCHWARTZ, F. J.
Institute of Marine Sciences
University of North Carolina
Morehead City, North Carolina 28557
RTLA 1233
SHUMWAY, S. E.
Marine Science Laboratories
Department of Marine Biology
University College of North Wales
Menai Bridge, Anglesey LL59 5EH
Wales
RTLA 1088, 1089
SIGEL, M. M.
Laboratory of Virology
Department of Microbiology
University of Miami School of Medicine
P. 0. Box 520875
Biscayne Annex
Miami, Florida 33152
RTLA 1378
SMITH, A. C.
Department of Pathology
University of Hawaii School of Medicine
The Biomedical Science Building
1960 East-West Road
Honolulu, Hawaii 96822
RTLA 1148, 1211A & B-1213A & B, 1232A & B
SMITH, C. E.
Fish Cultural Development Center
Fish and Wildlife Service
U.S. Department of the Interior
Route 2, Box 333
Bozeman, Montana 59715
RTLA 1151, 1210, 1219
SMITH, M. W.
Fish and Wildlife Service
U.S. Department of the Interior
P. 0. Box 4586
Panama City, Florida 32401
RTLA 1220
SWINNEY, G. N.
Freshwater Fisheries Unit
Department of Zoology
The University of Liverpool
Life Sciences Building
Crown Street
Liverpool L69 3BX, England
RTLA 1078
WOLF, H.
Fish Disease Laboratory
California Department of
Fish and Game
2111 Nimbus Road
Rancho Cordova, California 95670
RTLA 1173
WOLF, K. E.
Eastern Fish Disease Laboratory
U.S. Department of the Interior
Leetown, Route 1, Box 17A
Kearneysville , West Virginia 25430
RTLA 1376
WOLF, P. H.
New South Wales State Fisheries
Laboratories
211 Kent Street
Sydney, Australia 2000
RTLA 1117, 1170
WOLKE, R. E.
Department of Animal Pathology
Agricultural Experiment Station
University of Rhode Island
Kingston, Rhode Island 02881
RTLA 1124
YEVICH, P. P.
National Marine Water Quality
Laboratory
U.S. Environmental Protection
Agency
South Ferry Road
Narragansett , Rhode Island 02882
RTLA 1169, 1274-1374
ZWERNER, D. E.
Parasitology Section
Virginia Institute of Marine
Science
Gloucester Point, Virginia 23062
RTLA 1123
TEAR OUT ACCESSION SHEET
PLEASE SUBMIT TO:
Dr. John C. Harshbarger
Registry of Tumors in Lower Animals
National Museum of Natural History
Room W216-A
Smithsonian Institution
Washington, D.C., 20560, USA
DATE RECDo _
CONTRIBUTOR'S NOo
RTLA NO. _
USNM NO. _
NIH HISTOPATH NO.
COMMON NAME _ FAMILY _
PHYLUM _ _ GENUS _
CLASS _ SPECIES _
ORDER _
CATEGORY: NEOPLASM _ INFLAMMATION _ INFECTION _ PARASITIC
DEVELOPMENTAL _ TRAUMATIC _ NORMAL _ OTHER _
CONTRIBUTOR (NAME & ADDRESS): COLLECTOR (NAME & ADDRESS):
TOXIC
ITEMS SUBMITTED (QUANTITY):
GROSS MATERIAL _ PHOTOGRAPHS _
SLIDES _ REPRINTS _
BLOCKS _ OTHER _
ORIGIN OF ANIMAL: MARINE _ FRESHWATER _ ESTAURINE
WHERE COLLECTED _
TERRESTRIAL
date collected _ SEX _ AGE _ STAGE OF LIFE GYCLE
HOW KILLED _ FIXATION _
GROSS DESCRIPTION _
MICROSCOPE DX
COMMENTS (e.go, possible exposure to chemical pollutants or infectious agents, in¬
cidence and duration of this condition in the population, etc.)
(Please use reverse side, if more space is needed)
I '
CONTENTS
OVERVIEW . 1
TABLE I - DISTRIBUTION OF LESIONS AMONG
SPECIMENS ACCESSIONED . 3
REFERENCE LIBRARY . . . . . . . . . . . . 4
PAPERS SINCE 1975 . 4
SELECTED OTHER ACTIVITIES IN 1976 . 5
PERSONNEL . 5
ACCESSIONS . 7
INDEX OF NEOPLASM - ANIMAL GROUP - AND
RTLA NUMBER . 30
PHYLOGENETIC INDEX . . . 32
INDEX OF SPECIMENS BY SCIENTIFIC AND
COMMON NAMES . 34
CONTRIBUTORS . 39
TEAR OUR ACCESSION SHEET . . . . . . Last page
Smithsonian Institution
Washington, D.C.
1977
i
OVERVIEW
During 1976 the Registry of Tumors in Lower Animals fulfilled one de¬
cade as a diagnostic center, a literature center, a specimen depository,
a research group, and a general clearinghouse for information on neoplasia
and related disorders in invertebrate and poikilothermic vertebrate animals.
Its founding in 1966 (initially approved in 1965) was made possible by funds
provided by the National Cancer Institute, due largely to the efforts of
Drs. Clyde J. Dawe, Harold L. Stewart, Thelma B. Dunn, and Mearl F. Stanton,
and by space provided at the Smithsonian Institution due largely to the ef¬
forts of Dr. Donald F. Squires.
Two hundred thirteen accessions (several containing multiple specimens)
were added to the collection. The phylogenetic and the neoplastic versus
non-neoplastic distributions are given in Table I; an itemized list com¬
prises the body of this report. Among those specimens received was ma¬
terial from the largest tumor ever found in a lower animal, a 45 lb. lipoma,
from a 400 lb. bluefin tuna (RTLA 1518) contributed by Paul P. Yevich. No
epidemiological trend has appeared to suggest a cause for the one to sev¬
eral lipomas discovered annually in fish. Another tuna (albacore) which
had an osteoma (RTLA 1384) , a type of tumor usually associated with croak¬
ers, was contributed by Jerry D. Hendricks. Mr. Yevich also contributed a
lymphocytic leukemia in a brook trout (RTLA 1519) and two significant mol-
luscan tumors including a hematopoietic neoplasm of possible amoebocytic
origin in a black quahog (RTLA 1392), and a diffuse, undifferentiated sar¬
coma in an oyster (RTLA 1435) . Other molluscan specimens received with neo¬
plastic and non-neoplastic lesions were: a mussel from J. M. Ward, A. Guarino,
and W. L. Doyle which had a vesicular connective tissue tumor of the gonad
(RTLA 1474); an Asiatic clam from Brian S. Morton with granulomas associ¬
ated with incubating larvae (RTLA 1391) ; a three-ridge naiad from Fred Hink
and Carol Stein showing inflammatory polyps of the vesicular connective tis¬
sue (RTLA 1396); and, hard clams from Sara Otto, Sing C. Chang, and me, con¬
taining chlamydial inclusions (RTLA 1414-1418) . Chlamydia are obligate,
intracytoplasmic, zoonotic procaryotes believed to have evolved from bac¬
teria. They produce psittacosis in many species of birds and a type of pneu¬
monia in humans. This discovery suggests that hard clams and possibly other
mollusks play an intermediate host role, which could have large economic and
public health significance. A large number of soft clams were received from
John Hurst (RTLA 1448-1461) and from Edward Gilfillan (RTLA 1500-1515) from
several sites in Maine polluted with various petroleum products. While many
of these animals remain to be studied, initial findings confirm Paul Yevich *s
contention that germinomas arise in some of these populations. A polyoma
type virus was also found. A soft clam specimen from the Northeast U.S.
coast with a diffuse hematopoietic neoplasm was contributed by Robert Brown
(RTLA 1413).
Eight fish cases (RTLA 1478-1485) from coastal waters of southeast
Florida were contributed by Walter Kandrashoff who has observed an ...creaoe
in fish anomalies over the years as water in this area has become more pol¬
luted. Two of the lesions were neoplastic — a neurilemmoma in a mangrove
snapper and a mesothelioma in a carp. The other lesions appeared to be para¬
sitic or traumatic. Neurilemmomas had previously been reported in snappers
from southwest Florida (Key West/Dry Tortugas) by Lucke in 1942 and are reg¬
ularly received by the Registry from many species from widespread locations.
_2-
Other examples in this report include goldfish from I. M. Obdeyn (RTLA
1436) and R. R. Cowden (RTLA 1393), a brown trout from Barry J. Stevenson
(RTLA 1476), two sockeye salmon from Gordon R. Bell (RTLA 1492 and 1493),
and a black bullhead from C. Dale Becker (RTLA 1496). A rare albino Afri¬
can lungfish from N. Herwig with a pigmented malignant melanoma (RTLA 1495)
and a probable neurofibrosarcoma in a blue gourami from D. 0. Carpenter
(RTLA 1401) represent two additional neural tumors.
Another block of cases (RTLA 1531-1597) resulted from an Ohio River
Valley Water Sanitation Commission survey of the Ohio and Kanawha Rivers
coordinated by Bill Klein. Surprisingly, only about four neoplastic le¬
sions (papillomas) were found in this heavily industrialized watershed.
Since the method of collection was to rotenone lock chambers, it is quite
possible that the older bottom feeders most likely to have tumors are
least likely to migrate through lock chambers, and a different sampling
method will be needed to collect these fish.
Interesting reptile lesions received included a l5niiphoblastic leu¬
kemia in an Indian monitor lizard from J. N. Shively (RTLA 1499), a fibro¬
blastic sarcoma in a gopher snake from G. Pendlebury (RTLA 1400), a pan¬
creatic adenocarcinoma in a snake (Spilotes sp.) from Fred Frye (RTLA
1387), a parathyroid adenoma versus hyperplasia in a Greek tortoise from
Fred Frye (RTLA 1402), and papillomatosis in an emerald lizard from 0. F.
Jackson (RTLA 1389) .
An epidermal papilloma versus a low grade papillary carcinoma of a
tautog was contributed by Richard Wolke (RTLA 1434) . Five flatfish epi¬
dermal papillomas were received: one from an unpolluted area of Baja
California contributed by Marjorie Sherwood (RTLA 1390), and four from
Japan contributed by Keiichi Oishi (RTLA 1486 and 1516) and Takeo Harada
(RTLA 1487 and 1517) . A paper soon to be published in the "Journal of the
National Cancer Institute" by Wellings et al gives evidence that the X-cells
in these flatfish tumors and in cod pseudobranch tumors may be unicellular
organisms. Other possible unicellular organisms in fish are the rodlets
in the frequently seen rodlet cells several examples of which were contri¬
buted by E. K. Miller (RTLA 1463-1467). While some people think the rod-
lets are most likely some type of protozoans, I can see similarities to
some of the insect viruses.
In addition to the hematopoietic neoplasms already mentioned, Elisabeth
Gateff contributed two mutant Drosophila with "malignant blood neoplasms"
(RTLA 1489 and 1490). Dr. Gateff has identified more than 15 mutants on
three chromosomes that result in neoplasms of various origins. Hemato¬
poietic fish neoplasms also included a lymphosarcoma in a cutthroat trout
from Charlie Smith (RTLA 1399) and a northern pike from Gary Hoskins (RTLA
1442) .
Liver lesions included a hepatoma in a largescale sucker from C. Dale
Becker (RTLA 1395), a hepatoma or possibly a hepatoblastoma in a rainbow
trout from Charlie Smith (RTLA 1469) , diethylnitrosamine Induced hepatomas
in Medaka from Takatoshi Ishikawa (RTLA 1426) . Michael Sigel contributed
a tiger shark with multiple biliary duct cysts (RTLA 1412) .
DISTRIBUTION OF LESIONS AMONG SPECIMENS ACCESSIONED
/-*S
S'?
/--N
fO
00
iH
s
•
0
tH
a^
CO
tn
LT)
tH
as
0
rH
•
<o
04
rH
3
u
■o-
CN
v£5
rH
rH
LO
CM
CM
CO
o
cs
CO
<3-
iH
H
(H
CM
O'
T3
0)
M
O
tH
fi
60
■W cti
o
O
CM
o
o
in
o
0
O -H
2 'XS
CM
iH
CO
w
w
c
M
W
M
o
o
o
•H
w
4J
B^
ra
as
3
H
iH
r-.
00
&.
<t
LT)
O
'wt
OJ
e
CM
O
iH
rH
CN
o
CM
CM
1
tH
0
fi
tH
o
a
O'.
•H
Bv?
•<r
CM
CO
CO
<3-
m
V-r
v— t
iH
a
o
O
o
o
00
CM
0
<r
o
rH
<!•
iH
0)
IS
3
3
0
H
a
u
•H
MH
0)
3
x)
0 TJ
fi
«
cn
3
o
3
0)
OJ
•H
•H
4J
4^
Ph
•xs
H 3
60
1— 1
4-1
3
3
o
•H
3 0
o a
•H
•H
O
3
M
tH
tH
3 3
fH 3
4_)
•H
f— 1
4:
3
3
a 60
o
a.
B-
3
3
3
rH
4J
3
4-J
H 3
^ u
<v
O
42
3
O
3
0
3 "H
Pj 60
cd
<
PQ
CO
H
s
c
<
H
P-! TS
-4-
Muscle tumors were represented by a rhabdomyoma in a brown trout from
Barry J. Stevenson (RTLA 1477) and a leiomyosarcoma in a sockeye salmon
from Gordon Bell (RTLA 1475). Other cases of interest include a thyroid
adenoma in a butterfly fish from Michael Lagios (RTLA 1439) and in a striped
killifish from John Grizzle (RTLA 1525). A poorly-differentiated rainbow
trout nephroblastoma was contributed by Harold Wolf (RTLA 1446) . A rain¬
bow trout with an ectopic reduplication of visceral organs was received
from John Hnath (RTLA 1423) and Bob Anderson sent a sea peach showing ex¬
cess tunic production in response to a hydrozoan (RTLA 1406) .
REFERENCE LIBRARY
Approximately 200 papers were added to the comprehensive library on
neoplasms in lower animals bringing the total to 3,150. Except for re¬
cent acquisitions and articles that need to be translated, all papers have
been abstracted by selected key words and computerized.
PAPERS SINCE 1975
Billups, L. H. and Harshbarger, J. C. "Reptiles" a Section of the Chapter,
"Naturally Occurring Neoplastic Diseases". In: CRC Handbook of Laboratory
Animal Science, Vol. 3, E. C. Melby, Jr. and N. H. Altman (ed.), pp. 343-
356, (CRC Press, Inc., Cleveland 1976).
Leibovitz, L. , Harshbarger, J. C. , and Chanley, P. A Polypoid Myoma of the
Foot of a Surf Clam (Spisula solidisslma) . In: Proceedings of the First
International Colloquium on Invertebrate Pathology and IXth Annual Meet¬
ing Society for Invertebrate Pathology, Queen’s University at Kingston,
Canada, 1976, pp. 148-150, (Queen's University 1976).
Harshbarger, J. C. , Shuraway, S. E. , and Bane, G. W. Variably Differentia¬
ting Oral Neoplasms, Ranging from Epidermal Papilloma to Odontogenic
Ameloblastoma, in Gunners { (Tautogolabrus adspersus) Osteichthyes ; Per-
ciformes: Labridae}. In: Progress in Experimental Tumor Research, Vol.
20, F. Homburger (ser. ed.). Tumors in Aquatic Animals, C. J. Dawe, D. G.
Scarpelli, and S. R. Wellings (vol. ed.), pp. 113-128, (Karger, Basel 1976).
Harshbarger, J. C. Description of Polyps and Epidermal Papillomas in Three
Bivalve Mollusk Species. Mar. Fish. Rev., 25-29. 1976.
Harshbarger, J. C. "Spontaneous Neoplasms in Amphibians" and "Spontaneous
Neoplasms in Reptiles," two Sections of Chapter 1: "Tumors". In: Pathol¬
ogy of Laboratory Animals , Vol. 2, K. Benirschke, F. M. Garner, T. C.
Jones, and C. Kozma (ed.), (Springer-Verlrg, Nex: York; In press).
Harshbarger, J. C. The Role of the Registry of Tumors in Lower Animals in
the Study of Environmental Carcinogenesis in Aquatic Animals. Ann. N. Y.
Acad, Sci. (In press).
Anderson, R. S., Jordan, L. A., and Harshbarger, J. C. Tunic Abnormalities
of the Urochordate Halocynthia pyriformis (Rathke). J. Invertebr, Pathol.
(In press) .
-5-
Harshbarger, J. C. , Chang, S. C., and Otto, S. V. Chlamydiae (with Phages),
Mycoplasmas, and Rickettsiae in Chesapeake Bay Bivalves. Science. (In
press) .
Rose, F. L. and Harshbarger, J. C, Neoplastic and Possibly Related Skin
Lesions in Neotenic Tiger Salamanders, Amby stoma tlgrinum, from a
Sewage Lagoon. Science. (In press).
SELECTED OTHER ACTIVITIES IN 1976
1. Convened a symposium on invertebrate tumors at the Annual Meeting of
the Society for Invertebrate Pathology, Kingston, Ontario, Canada,
August 1976, and co-authored one of the presentations at that symposium.
2. Served as Secretary of the Society for Invertebrate Pathology until
August 1976 and subsequently as a member of the Permanent Program
Committee.
3. Served as Secretary of the Washington, D.C. Chapter of Sigma Xi, The
Scientific Research Society of North America.
4. Served as a member of the Planning Committee, as a Session Chairman,
and as a speaker at the New York Academy of Sciences Conference en¬
titled; ’’Aquatic Pollutants and Biological Effects with Emphasis on
Neoplasia,” held 27-29 September 1976.
5. Served as a member of the Committee on Animal Models and Genetic Stocks
of the National Research Council of the National Academy of Sciences.
6. Served as a member of the Interagency Collaborative Group on Environ¬
mental Carcinogenesis (chaired by H. F. Kraybill of the U.S. National
Cancer Institute).
7. Participated in a cooperative investigation of the etiology of several
diseases in bivalve mollusks, supported in part by the U.S. Food and
Drug Administration, which has resulted in the discovery of chlamydiae,
mycoplasmas, rickettsiae, and polyoma viruses in these animals.
8. Made a field survey of fish collected from nine sites on the Ohio River
and one site on the Kanawha River, for tumors, as part of the annual
fish survey conducted by the Ohio River Valley Water Sanitation Com¬
mission.
PERSONNEL
The Project Officer for the contract is Dr. Clyde J. Dawe, Head, Com¬
parative Oncology Section, Laboratory of Pathology, National Cancer Insti¬
tute, National Institues of Health, Bethesda, Maryland, 20014.
The Principal Investigator for the contract is Dr. W. Duane Hope,
Chairman, Department of Invertebrate Zoology, National Museum of Natural
-6-
History, Smithsonian Institution, Washington, D.C., 20560.
The Staff of the Registry is as follows;
John C. Harshbarger, Ph.D. - Director
Sing Chen Chang, Ph.D. - Electron Microscopist
Phyllis M. Schellenger, B.S. -- Registrar
Linda J. Cullen, B.A. - Histopathology Technician
Judith E. Foster, B.S. -- Research Assistant
Marilyn S. Slatick, B.S. ~ Bibliographer
ACCESSIONS
RTLA 1384. Albacore, Thunnus alalunga
Material: Three separate, but consecutive segments of the vertebral
column — 2 "normal"; 1 pathologic — pathologic segment
has an attached ossified growth
Habitat: Northeastern Pacific Ocean
Diagnosis: Osteoma
Submitter: J. D. Hendricks
RTLA 1385. Iguana iguana
Material: Four microscope slides; 1 pathology record
Habitat: Pet; California
Diagnosis: Lymphoma; poorly-differentiated lymphocytic type
Submitter: F. L. Frye
RTLA 1386. Indian monitor lizard, Varanus bengalensis
Material: Five microscope slides
Diagnosis: Osteocartilaginous exostoses
Submitter: F. L. Frye
Reprint: Frye, Fredric L. and Frank Dutra, Multiple Osteocartilagi¬
nous Exostoses in a Monitor Lizard, Vet. Med. Small Anim.
Clin., 68: 1414-1416. 1973.
RTLA 1387. Spilotes sp.
Material: One microscope slide
Diagnosis: Pancreatic adenocarcinoma
Submitter: F. L. Frye
RTLA 1388. Clemmys sp.
Material: Three microscope slides
Diagnosis: Verrucal papillomatosis
Submitter: F. L. Frye
RTLA 1389. Green lizard, Lacerta viridis
Material: Two, 35 mm color transparencies; 1 pathology record
Diagnosis: Squamous keratotic papillomatosis
Submitter: 0. F. Jackson
RTLA 1390. Dover sole, Microstomus pacif Icus
Material: Granular raised growths which were scattered over the
body wall and fins
Habitat: Pacific Ocean off Baja California
Diagnosis: Papilloma
Submitter: M. J. Sherwood
Reprint: Sherwood, Marjorie J. and Alan J. i,e ,ins. Occurrence of
Tumor-Bearing Dover Sole (Microstomus pacif icus) Off
Point Arguello, California and Off Baja California, Mexico.
Trans. Am. Fish. Soc., 105(4): 561-563. 1976.
-8-
RTLA 1391. Asiatic clam, Corbicula fluminea
Material: Nine microscope slides representing 4 cases
Habitat: Plover Cove Reservoir, Hong Kong
Diagnosis: Inflammatory granulomas
Submitter: B. Morton
Reprint: Morton, Brian. The Occurrence of Inflammatory Granulomas
in the Ctenidial Marsupium of Corbicula fluminea (Muller
1774) (Mollusca; Bivalvia) - Consequence of Larval In¬
cubation. (In preparation).
RTLA 1392. Black quahog, Artica islandica
Material: Fourteen microscope slides (pathologic);
slides ("normal”)
Habitat: Rhode Island Sound
Diagnosis: Hematopoietic neoplasm, amoebocytic type
Submitter: P. P. Yevich
12 microscope
RTLA 1393. Goldfish, Carassius auratus
Material: Five microscope slides
Habitat: Outdoor pool
Diagnosis: Neurilemmoma
Submitter: R. R. Cowden
RTLA 1394. Longear sunfish, Lepomis megalotis
Material: Gross specimen
Habitat: Laboratory
Diagnosis: Prolapsed rectum
Submitter: W. E. Smith
RTLA 1395. Largescale sucker, Catostomus macrocheilus
Material: "Diseased" liver including the spleen and part of the
intestine
Habitat: Columbia River, Washington
Diagnosis: Well-differentiated hepatoma
Submitter: C. D. Becker
RTLA 1396. Three-ridge naiad, Amblema plicata
Material: One pathologic and one "normal" specimen including soft
tissues and 4 shells; 2 black and white photographs
Habitat: Mohican River, Ohio
Diagnosis: Inflammatory polyp
Submitter: W. F. Hink and C. B. Stein
RTLA 1397. Rainbow trout, Salmo gairdneri
Material: Two pieces of tissue from a growth attached to the lower
jaw; 2 microscope •^lides
Habitat: Fish Cultural Development Center, Bozeman, Montana
Diagnosis : Fibroma
Submitter: C. E. Smith
RTLA 1398. Lake trout, Salvelinus namaycush
Material: A piece of tissue from a growth; 4 microscope slides;
2, 35 mm color transparencies
-9-
RTLA 1398 (contd.)
Habitat: Flathead Lake, Montana
Diagnosis :
Fibrolipoma
Submitter:
C. E. Smith
RTLA 1399. Lahontan cutthroat trout, Salmo clarki
Material :
Habitat ;
Diagnosis ;
Submitter:
Two pieces of tissue from a growth; 2 microscope slides
Lahontan National Fish Hatchery, Gardnerville, Nevada
L^phosarcoma
C . E . Smith
RTLA 1400. Great Basin gopher snake, Pituophis melanoleucus deserticola
Material:
Fourteen microscope slides from a growth in the cloacal
region; 1 black and white photograph
Habitat :
Diagnosis :
Submitter :
Near Bruneau Dunes State Park, Idaho
Fibroblastic sarcoma
G. Pendlebury
RTLA 1401. Blue gourami, Trichogaster trlchopterus sumatranus
Material; One gross specimen with a growth near the base of the tail
Diagnosis: Sarcoma of probable neural origin; neurilemmal sarcoma
Submitter: D. 0. Carpenter
RTLA 1402. Greek tortoise, Testudo graeca
Material ;
Diagnosis :
Submitter :
One microscope slide
Parathyroid adenoma versus compensatory hyperplasia
F. L. Frye
RTLA 1403, 1404,
Material :
, 1408-1411, 1419, 1421, 1422. Iguana iguana
Two to four microscope slides each; pathology reports for
4 cases
Diagnosis :
Metabolic disorder characterized collectively by minerali¬
zation of renal vessels, dilation of renal tubules, crys¬
tals in lumens of renal tubules and in spleen, histiocytic
islands in spleen, collections of mature lymphocytes in
liver sinusoids
Submitter:
F. L. Frye
RTLA 1405. Rummy nose tetra, Hemigrannus rhodostomus
Material:
Habitat :
One gross specimen with a protrusion on the right side
The specimen arrived at a San Antonio, Texas, pet shop from
a tropical fish wholesaler with the growth already present
Diagnosis :
Submitter:
Two cysts containing worm parasites
N. Herwig
RTLA 1406, Sea
Material :
Habitat :
Diagnosis :
Submitter:
peach, Halocynthia pyriformis
One gross specimen with an exuberant growth of the tunic
Bay of Fundy
Excess tunic production in response to a hydrozoan
R. S. Anderson
RTLA 1407. Coho salmon, Oncorhynchus kisutch
Material; One microscope slide
-10-
RTLA 1407 (contd.)
Habitat: Pacific Biological Station, Nanaimo.
Diagnosis: Undifferentiated sarcoma
Submitter: G. E, Hoskins
>. C. , Canada
RTLA 1408-1411. (See RTLA 1403)
RTLA 1412. Tiger shark, Galeocerdo cuvieri
Material: Three microscope slides; 1 pathology report
Diagnosis: Multiple biliary duct cysts
Submitter: M. M. Sigel
RTLA
1413. Soft-shell clam, Mya arenaria
Material: Three microscope slides
Diagnosis: Diffuse neoplasm of hyaline hemocyte origin
Submitter: R. Brown
RTLA 1414-1418.
Material:
Habitat :
Diagnosis :
Submitter :
Reprint :
Hard-shell clam, Mercenaria mercenaria
Digestive tissue
Maryland part of Chincoteague Bay
Chlamydiae inclusions
S. V. Otto, J. C. Harshbarger, and S. C. Chang
Harshbarger, John C., Sing Chen Chang, and S. V. Otto.
Chlamydiae (with Phages), Mycoplasmas, and Rickettsiae
in Chesapeake Bay Bivalves. Science. (In press).
RTLA 1419. (See RTLA 1403)
RTLA 1420. Pacific pond turtle, Clemmys marmorata '
Material: Two microscope slides
Diagnosis: Intranuclear virus inclusions in liver, kidney, and spleen
Submitter: F. L. Frye
RTLA 1421 and 1422. (See RTLA 1403)
RTLA 1423. Rainbow trout, Salmo gairdneri
Material: One tissue block
Habitat: Little Manistee River, Michigan
Diagnosis: Ectopic reduplication of visceral organs
Submitter: J. G. Hnath
RTLA 1424. Bullsnake, Pituophis melanoleucus
Material: 'Two microscope slides; 1 color transparency
Diagnosis: Algal infection. Prototheca sp., versus fungal infection
Submitter: T. E. Hamm
RTLA
1425. Carp
Material:
Habitat :
Diagnosis :
Submitter :
, Cyprinus carpio
One piece of tissue; 2 microscope slides; 2 color trans¬
parencies
Private pond in Mystic, Connecticut
Leiomyoma versus teratoma
R. E. Wolke
-11-
RTLA
1426. Cisco
Material :
Habitat :
Diagnosis :
Submitter:
j Coregonus artedil
Section of liver tissue
Smith Bay, on the eastern shore of the northern end of
Lake George, New York
Cholangioma or cholangiocarcinoma
C. J. George
RTLA 1427. American anole, Anolis carolinensis
Material: Gross specimen with liimp on neck;
Habitat: Pet; Maryland
Diagnosis: Epithelial lined cyst of probable
Submitter:
etiology unknown
F . McQuay
2 microscope slides
pharyngeal origin —
RTLA 1428. Iguana iguana
Material: Two microscope slides
Habitat: Raised in captivity since 1965;
Diagnosis: Pyelonephritis
Submitter: F. L. Frye
California
RTLA 1429. Pacific pond turtle, Clemmys marmorata
Material: Two microscope slides
Diagnosis: Intranuclear virus-like inclusions in liver, kidney, and
spleen
Submitter: F. L. Frye
RTLA 1430 & 1431. Mt. Whitney rainbow trout, Salmo gairdneri
Material: One microscope slide each
Diagnosis: Chronic inflammation and fibrosis with hyperplasia of
overlying lip epidermis, probably due to traiama
Submitter: H. Wolf
RTLA 1432. Earthworm
Material: Two vials — one containing multiple minute white cysts —
the other containing 3 gross earthworm specimens
Diagnosis: Simultaneous infections of protozoa, nematodes, and
bacteria
Submitter: D. Armstrong, E. L. Cooper, and E. Stein
RTLA 1433. Pacific halibut, Hippoglossus stenolepis
Material: A piece of a large tumor
Diagnosis: Traumatic cyst in body wall
Submitter: G. E. Hoskins
RTLA 1434. Tautog (Black fish), Tautoga onitis
Material: Four pieces of tissue excised from a growth; 2 ih _jlOSc^ pe
slides; 1, 35 mm color transparency
Diagnosis: Epidermal papilloma versus low-grade papillary carcinoma
of the jaw
Submitter: R. E. Wo Ike
RTLA 1435. American oyster, Crassostrea virginica
-12-
RTLA 1435 (contd.)
Material: Two microscope slides
Habitat: New Haven area of Long Island Sound
Diagnosis: Diffuse undifferentiated mesenchymal sarcoma
Submitter: P. P. Yevich
RTLA 1436. Goldfish, Carassius auratus
Material: Four microscope slides; 1 paraffin block; 1 color trans¬
parency
Habitat: In summer fish lives in a garden pond; in winter in an
aquarium together with 2 other goldfishes
Diagnosis: Neurilemmoma
Submitter: I. M. Obdeyn
RTLA 1437. Red-eared turtle, Chrysemys scripta elegans
Material: One microscope slide
Diagnosis: Leukoplakia and dyskeratosis possibly transitional to a
well-differentiated squamous carcinoma
Submitter: F. L. Frye
RTLA 1438. Hard-shell clam, Mercenaria mercenaria
Material: Digestive tissue
Habitat: Maryland part of Chincoteague Bay
Diagnosis: Chlamydiae inclusions
Submitter: S. V. Otto, J. C. Harshbarger, and S. C. Chang
Reprint: (See RTLA 1414-1418)
RTLA 1439. Butterfly fish, Chelmon rostratus
Material: One microscope slide; 2 color transparencies; 3
photomicrographs; 1 pathology report
Habitat: A pet in a home aquarium
Diagnosis: Thyroid adenoma
Submitter: M. D. Lagios
electron
RTLA 1440. California moray, Gymno thorax mordax
Material: One microscope slide
Diagnosis: Epidermal papilloma of the lip
Submitter: M. D. Lagios
RTLA 1441. Chinook salmon, Oncorhynchus tschawytscha
Material: Two pieces of body wall from the caudal peduncle with
hard fibrous lumps in the muscle
Habitat: Upper Rakaia River, Canterbury, South Island, New Zealand
Diagnosis: Traumatic atrophy of the muscle
Submitter: P. M. Hine
RTLA 1442. Northern pike, Esox lucius
Material: An intact section of fish with an ulcerated lesion; 1
microscope slide; 2 color transparencies
Diagnosis: L3nnphosarcoma
Submitter: G. E. Hoskins
RTLA 1443. Rainbow trout, Salmo gairdneri
-13-
RTLA 1443 (contd»)
Material: Three microscope slides
Habitat:
Diagnosis i
Mojave River Hatchery, California
Toxicosis characterized by intestinal peritonitis, liver
edema and necrosis, and gill inflammation and microaneurysms
Submitter:
H, Wolf
RTLA 1444. American oyster, Crassostrea vlrginica
Material:
Habitat :
Diagnosis :
Submitter:
One microscope slide; 1 pathology report; 2 reprints
Herring Bay: Western shore of Chesapeake Bay
Xenoma due to ciliated thigmotrichs
S. V. Otto
RTLA 1445. Bluntnose minnow, Pimephales notatus
Material i
One gross specimen with 3, white, amorphous lesions: on
the head; below dorsal fin; and near the vent. Specimen
also had numerous cutaneous black spots scattered randomly
over the body surface and fins.
Habitat:
Diagnosis i
Trace Creek, Tennessee
Epidermal hyperplasia and black spot disease characterized
by melanophore proliferation in trematode granulomas
Submitter:
J. Grizzle
RTLA 1446. Rainbow trout, Salmo gairdneri
Material:
Habitat;
Diagnosis :
Submitter:
One microscope slide
Fish Springs Hatchery, California
Poorly-differentiated nephroblastoma
H. Wolf
RTLA 1447. Common shiner, Notropls comutus
Material :
Habitat :
Diagnosis :
Submitter i
One gross specimen
Ramapo River, New York
Protozoan cysts, probably Myxobolus sp.
C. L. Smith
RTLA 1448-1461.
Material:
Habitat;
Diagnosis ;
Soft-shell clam, Mya arenaria
Several himdred whole clams from 14 petroleum spill sites
Searsport, Maine
Germinomas (RTLA 1453-1458) , intranuclear virus-inclusions
(RTLA 1458), gill hyperplasia (RTLA 1448-1461), trematode
parasites (1448-1461) , and cytoplasmic inclusions (RTLA
1448-1451)
Submitter:
J. Hurst
RTLA 1462, Montana (Arctic) grayling, Thymallus arcticus
Material:
Diagnosis i
Two microscope slides; 1 paraffin block
Excavating fungal granuloma of mandible associated with
ectopic bone formation
Submitter:
C. E. Smith
RTLA 1463-1465.
Clownfish, Amphlprlon ocellaris
-14-
RTLA 1463-1465 (contd.)
Material; Four microscope slides each
Habitat: In vitro spawn
Diagnosis: Rodlet cells
Submitter: E. K. Miller
RTLA 1466. Planehead filefish, Monacanthus hispidus
Material: Two microscope slides
Habitat: Gulf of Mexico
Diagnosis: Rodlet cells
Submitter: E. K. Miller
RTLA 1467. Three-spot damsel, Dascyllus trimaculatus
Material: Two microscope slides
Habitat: South Pacific
Diagnosis: Rodlet cells
Submitter: E. K. Miller
RTLA 1468. Coho salmon, Oncorhynchus kisutch
Material: A large growth and adjacent body wall; 1 microscope slide;
1, 35 mm color transparency
Habitat: French Creek, Vancouver Island, B.C., Canada
Diagnosis: Fibrosarcoma
Submitter: G. E. Hoskins
RTLA 1469. Rainbow trout, Salmo gairdneri
Material: Two pieces of liver tissue; 2 microscope slides
Habitat: Mattawan State Hatchery, Michigan
Diagnosis: Possible hepatoblastoma
Submitter: C. E. Smith
RTLA 1470. Fathead minnow, Pimephales promelas
Material: Two microscope slides
Diagnosis: Liposarcoma (?)
Submitter: C. E. Smith
RTLA 1471. Medaka, Oryzias latipes
Material: Manuscript; 8 color prints; 11 black and white prints
Habitat: Obtained from a commercial breeder; maintained in labora¬
tory tanks
Diagnosis: Diethylnitrosamine induced hepatoma
Submitter: T. Ishikawa
Reprint: Ishikawa, Takatoshi, Tetsuro Shimamine, and Shozo Takayama.
Histologic and Electron Microscopy Observations on Di-
ethylnitrosamine-Induced Hepatomas in Small Aquarium Fish
(Oryzias latipes) . J. Nat. Cancer Inst., ^(4): 909-917.
1975.
RTLA 1472. Earthworm
Material: Three microscope slides
Habitat: Anderson County, Tennessee
Diagnosis: Granulomas due to nematode infestation
Submitter: G. E. Cosgrove
-15-
RTLA 1473. Fathead minnow, Plmephales promelas
ifeterial: One half of the head with multiple large ttmors; 3 black
and white photographs
Diagnosis! Liposarcoma
Submitter; C. E. Smith
RTLA 1474. Mussel, Mytilus sp.
Material! One microscope' slide
Habitat: Mt, Desert Island Biological Laboratory, Salsbury Cove,
Maine
Diagnosis: Vesicular connective tissue neoplasm in gonad of a hermaph-
orditic mussel
Submitter: J. M, Ward, A. Guarino, and W. L. Doyle
RTLA 1475. Sockeye salmon, Oncorhynchus nerka
Material; Large growth associated with the ovaries
Diagnosis: Leiomyosarcoma
Submitter; G. R, Bell
RTLA 1476. Brown trout, Salmo trutta
Material: Two microscope slides; 2 color transparencies
Habitat: Lake Benmore, New Zealand
Diagnosis: Neurileramal sarcoma
Submitter; B. Stevenson
RTLA 14/7. Brown trout, Salmo trutta
Material; Two microscope slides; | color transparencies
Habitat: Lake Rotorua, New Zealand
Diagnosis: Two lesions: neurileramal sarcoma;
rhabdomyoma
Submitter: B. Stevenson
well-differentiated
RTLA 1478. Pinfish, Lagodon (?) rhomboides (?)
Material: Gross specimen with misaligned lower jaw
Habitat; Miamarina — North Biscayne Bay adjacent to the Miami River
Florida
Diagnosis: Encystment of trematode parasites within the skeletal
muscle of the jaw
Submitter: W. Kandrashoff
RTLA 1479. Pinfish, Lagodon (?) .rhomboides (?)
Material: Gross specimen with wound-like depression predominantly
on right side, dorsally
Habitat: Miamarina -- North Biscayne Bay adjacent to the Miami River
Florida
Diagnosis: Probable trauma; tissue too autolyzed definitive diag¬
nosis
Submitter: W. Kandrashoff
RTLA 1480. Menhaden, Brevoortla sp.
Material: Two caudal fins with similar raised lesions
Habitat: North Biscayne Bay, Florida
Diagnosis: Healing fractures of the fin ribs, probably due to traioma
Submitter; W. Kandrashoff
-16-
RTLA 1481. Mangrove (gray) snapper, Lutjanus griseus
Material :
A spherical growth with some skin and scales attached from
the side of the specimen
Habitat:
Diagnosis :
Submitter:
Reef area of South Florida
Neurilemmoma
W. Kandrashoff
RTLA 1482. Black drum, Pogonias cromis
Material:
Habitat:
Diagnosis :
Submitter:
One eyeball with undilated pupil
North Biscayne Bay, Florida
Undetermined
W. Kandrashoff
RTLA 1483. Atlantic (?) bonito, Sarda (?) sarda (?)
Material:
Habitat :
Diagnosis :
Large piece of body wall with deep ulceration of skin
Just off Miami Beach, Florida
Infection and inflammation following a severe injury to
the body wall
Submitter:
W. Kandrashoff
RTLA 1484. Florida pompano, Trachinotus carolinus
Material :
Habitat :
Diagnosis :
Submitter:
Caudal fin with several lumps
Probably area around Ft. Pierce, Florida
Undetermined
W. Kandrashoff
RTLA 1485. Carp, Cyprinus carpio
Material:
Large, white spherical growth found lying free in the
abdominal cavity
^ Diagnosis:
Submitter:
Mesothelioma of probable ovarian origin
W. Kandrashoff
RTLA 1486. Kareius bicoloratus
Material: One gross specimen with a large lesion involving both the
Habitat :
dorsal and ventral sides of the fish and most of the ven¬
tral fin
Okhotsuk Sea, outside of the Komuke Lake, Mombetsu,
Diagnosis :
Submitter:
Reprint :
Hokkaido Island, Japan
Epidermal papilloma
K. Oishi
Oishi, Keiichi, Fumio Yamazaki, and Takeo Harada. Epider¬
mal Papillomas of Flatfish in the Coastal Waters of
Hokkaido, Japan. J. Fish. Res. Board Can., 33(9): 2011-
2017. 1976.
RTLA 1487. Starry flounder, Platich-ibyo stcllatus
Material :
One gross specimen with a large growth involving both the
dorsal and ventral sides of the fish and a portion of the
ventral fin
Habitat:
Diagnosis :
Okhotsuk Sea, outside of the Komuke Lake, Mombetsu,
Hokkaido Island, Japan
Epidermal papilloma
Diagnosis :
-17-
RTLA 1487 (conLd.)
Submitter: T. Harada
Reprint: (See RTLA 1486)
RTLA 1488. Rainbow trout, Salmo gairdneri
Material: One gross specimen with multiple lesions on the body wall
and in the webbing of the fins
Diagnosis: Marked basal cell hyperplasia with cellular atypia sug¬
gestive of carcinoma situ
Submitter: C. E. Smith
RTLA 1489. Drosophila melanogaster
Material; One microscope slide
Habitat: Laboratory stock
Diagnosis: Lethal (2) malignant blood neoplasm {l(2)mbn}
Submitter: E. Gateff
Reprint: Gateff, Elisabeth. Neoplasms of Genetic Origin in
Drosophila melanogaster. In: Proceedings of the First
International Colloquium on Invertebrate Pathology and
IXth Annual Meeting Society for Invertebrate Pathology,
Queen’s University at Kingston, Canada, 1976. pp. 142-
146. 1976.
RTLA 1490. Drosophila melanogaster
Material: One microscope slide
Habitat: Laboratory stock
Diagnosis: Lethal (3) malignant blood neoplasm {l(3)mbn}
Submitter: E. Gateff
Reprint: (See RTLA 1489)
RTLA 1491. Rainbow trout, Salmo gairdneri
Material: Two microscope slides
Diagnosis: Epidermal hyperplasia
Submitter: C. E. Smith
RTLA 1492. Sockeye salmon, Oncorhynchus nerka
Material: One microscope slide
Diagnosis: Neurilemmal sarcoma
Submitter: G. R. Bell
RTLA 1493. Sockeye salmon, Oncorhynchus nerka
Material: Two microscope slides
Diagnosis: Neurilemmoma
Submitter: G. R. Bell
RTLA 1494. Dolly Varden, Salvelinus malma
Material: Two microscope slides
Habitat: Ospika River, Willis ton Lake,
Diagnosis: Myxofibroma
Submitter: G. E. Hoskins
B . C . , Canada
RTLA 1495. African lungfish (albino), Protopterus dolloi
-18-
RTLA 1495 (contd.)
Material ;
A portion of intestine with the remainder of a black,
firm, oval growth; 12, 35 mm color transparencies
Habitat :
From collection at the San Antonio Zoological Gardens and
Aquarium, San Antonio, Texas
Diagnosis :
Melanosarcoma
Submitter :
N. Herwig
RTLA
1496. Black bullhead, Ictalurus melas
Material:
A large growth removed from the right side of the fish;
2 black and white photographs
Habitat :
Laboratory reared for several months
Diagnosis :
Neurilemmoma
Submitter:
C. D. Becker
RTLA
1497. Hard-
-shell clam, Mercenaria mercenaria
Material:
Digestive tissue
Habitat :
Maryland part of the Chincoteague Bay
Diagnosis :
Chlamydiae inclusions
Submitter:
S, V. Otto, J. C. Harshbarger, and S. C. Chang
Reprint :
(See RTLA 1414-1418)
RTLA
1498. Hard-
-shell clam, Mercenaria mercenaria
Material:
Digestive tissue
Habitat :
Maryland part of the Chincoteague Bay
Diagnosis :
Chlamydiae inclusions
Submitter:
S. V. Otto, J. C. Harshbarger, and S. C. Chang
Reprint :
(See RTLA 1414-1418)
RTLA
1499. Indian monitor lizard, Varanus bengalensis
Material :
Wet tissue; 4 microscope slides
Habitat:
Randolph Park Zoo, Tucson, Arizona
Diagnosis :
Ljmiphoblastic leukemia
Submitter:
J. N. Shively
RTLA
1500. Soft-
-shell clam, Mya arenaria
Material :
Twenty whole clams
Habitat :
Hezzies Point, Maine
Diagnosis:
Normal
Submitter:
E. Gilfillan
RTLA
1501-1515.
Soft-shell clam, Mya arenaria
Material :
Several hxandred whole clams, total from 15 petroleum spill
sites
Habitat:
Searsport, Maine
Diagnosis :
Germinomas (RTLi-. 1501, 1503, 1505, 1507-1510, 1513);
cytoplasmic inclusions (RTLA 1501-1515) ; gill hyperplasia
(RTLA 1501-1515)
Submitter:
E. Gilfillan
RTLA
1516. Limanda schrenki
Material :
One gross specimen with a large growth involving both the
-19-
RTLA 1516 (contd.)
dorsal and ventral sides of the caudal fin. Specimen also
Habitat :
Diagnosis :
Submitter:
had two growths attached to the webbing of the dorsal fin
and opaque, slightly raised patches of skin randomly
scattered over the body wall on the ocular side.
Notoro Lake, Abashiri City, Japan
Epidermal papilloma; parasitization by Philometra mariae
K. Oishi
RTLA 1517. Limanda schrenki
Material:
One gross specimen with a large growth involving both the
ocular and blind sides of the fish and a portion of the
dorsal fin. Specimen also had two growths attached to the
webbing of the dorsal fin.
Habitat :
Diagnosis :
Submitter:
Notoro Lake, Abashiri City, Japan
Epidermal papilloma; parasitization by Philometra mariae
T . Harada
RTLA 1518. Bluefin tunna, Thunnus thynnus
Material :
Tissue from a 45 lb. mass located on the back of the fish;
Habitat :
Diagnosis :
Submitter:
3 microscope slides; 6 paraffin blocks
Atlantic Ocean
Lipoma
P. P. Yevich
RTLA 1519. Brook trout, Salvelinus fontinalis
Material: Tissue; 10 microscope slides; 12 paraffin blocks
Diagnosis: Lymphocytic leukemia
Submitter: P. P. Yevich
RTLA 1520. South African clawed frog, Xenopus laevis
Material :
Habitat :
Diagnosis :
Six microscope slides
Laboratory
Ova regression; probably induced by hormone injection being
out of phase with the level of ovarian maturation
Submitter:
G. E. Cosgrove
RTLA 1521. Spot, Leiostomus xanthurus
Material: Gross specimen with a growth displacing the pectoral fin
Habitat :
Diagnosis :
Submitter:
Specimen also had mucus-like, opaque patches of skin
randomly scattered over the body wall.
Patuxent River, Maryland
Microsporidan xenoma
J. Peng
RTLA 1522. Chinook salmon, Oncorhynchus tsL^^.^, tscha
Material:
A portion of body wall with an attached protruding ul¬
cerated lesion
Habitat :
Diagnosis :
Submitter:
Little Manistee River, near Manistee, Michigan
Well-differentiated fibrosarcoma
J. G. Hnath
^20-
RTLA 1523. Marine toad, Bufo marinus
Material:
One gross specimen with multiple, cyst-like lesions on
liver
Habitat :
Diagnosis :
Submitter;
Probably collected in Barro Colorado Islands, Panama
Parasitic cysts containing egg-laden trematodes
G. R. Zug
RTLA 1524. Green lizard, Lacerta viridis
Material ;
Habitat ;
Diagnosis ;
Submitter ;
Three microscope slides; 2 color transparencies
Pet
Verrucal type of squamous papillomatosis
0. F. Jackson
RTLA 1525. Striped killifish, Fundulus majalls
Material:
One gross specimen with a growth protruding from under
the opercula
Diagnosis :
Submitter:
Thyroid hyperplasia (colloid goiter)
J. Grizzle
RTLA 1526. Banded cichlid (?), Cichlasoma severum
Material :
Three pieces of tissue from a growth just below skin
between swimbladder and gill chamber
Habitat :
Diagnosis :
Submitter:
Aquarium
Renal tubular carcinoma versus nephroblastoma
J. Grizzle
RTLA 1527. Largemouth bass, Micropterus salmoldes
Material :
'Two portions of body wall with nodules associated with
■ muscle just under the skin
Habitat :
Diagnosis :
Submitter :
Table Rock Reservoir, near Branson, Missouri
Multiple infectious granulomas
J. Grizzle
RTLA 1528. Largemouth bass, Micropterus salmoldes
Material: Lower jaw with growth
Diagnosis: Osteochondroma versus a healing fracture
Submitter: J. Grizzle
RTLA 1529. Gulf menhaden, Brevoortia patronus
Material ;
One gross specimen with a growth attached to the left
side of the upper jaw
Habitat :
Diagnosis :
Submitter:
Gulf Shores, Alabama
Edematous snout
J. Grizzle
RTLA 1530. Bluegill, Lepor^is iLacrochirus
Material: The caudal fin and adjacent body wall with a growth near
Habitat:
Diagnosis :
Submitter:
the base of the caudal fin
Farm pond, Haralson County, Georgia
Granuloma
J. Grizzle
-21™
RTLA 1531. Carp, Cyprinus carpio
Material; One gross specimen with a black spot at the fork of the
caudal fin
Habitat; Ohio River; Dashfield Lock and Dam (L & D)
Diagnosis; Chronic inflammatory reaction
Submitter; ORSANCO Survey
RTLA 1532. Carp, Cyprinus carpio
Material; Eroded caudal, pectoral and pelvic fins
Habitat; Ohio River; Dashfield L & D
Diagnosis; Not processed
Submitter; ORSANCO Survey
RTLA 1533. White catfish, Ictalurus catus
Material; Kidney with a white body; a small mesenteric cyst
Habitat; Ohio River; Dashfield L & D
Diagnosis; Normal stannius body; cyst not determined
Submitter; ORSANCO Survey
RTLA 1534. White catfish, Ictalurus catus
Material; Fish head with lesion under jaw
Habitat; Ohio River; Dashfield L & D
Diagnosis; Ulcerated inflammatory reaction
Submitter; ORSANCO Survey
RTLA 1535, White catfish, Ictalurus catus
Material; Stannius bodies
Habitat; Ohio River; Dashfield L & D
Diagnosis; Normal
Submitter; ORSANCO Survey
RTLA 1536. Minnow
Material; Gross specimen with a ventral lesion behind the lower jaw
Habitat; Ohio River; Hannibal L & D
Diagnosis; Bacterial granuloma
Submitter; ORSANCO Survey
RTLA 1537. Catfish
Material; A piece of tissue; fish had discolorations on the right
side, dorsally, just posterior to the operculum
Habitat; Ohio River; Hannibal L & D
Diagnosis; Dermal inflammation overlain by thinned goblet cell less
epidermis
Submitter; ORSANCO Survey
RTLA 1538. Gizzard shad, Dorosoma cepedi aaum
Material: Fish head with corneal overgrowth
Habitat; Ohio River; Hannibal L & D
Diagnosis; Hemorrhage and fibrosis
Submitter: ORSANCO Survey
RTLA 1539. Flathead catfish, Pylodictis olivaris
-22-
RTLA 1539 (contd.)
Material: Viscera
Habitat: Ohio River; Hannibal L & D
Diagnosis: Hepatic arteritis
Submitter: ORSANCO Survey
RTLA 1540. Channel catfish, Ictalurus punctatus
Material: Gut with parasite; eye lesion
Habitat: Ohio River; Hannibal L & D
Diagnosis: Cestode; paraorbital inflammation and scarring
Submitter: ORSANCO Survey
RTLA 1541. Channel catfish, Ictalurus punctatus
Material: Two pieces of anal tissue showing apparent erosion
Habitat: Ohio River; Hannibal L & D
Diagnosis: Ulcerative inflammatory reaction
Submitter: ORSANCO Survey
RTLA 1542. Channel catfish, Ictalurus punctatus
Material: Two pieces of a black skin lesion
Habitat: Ohio River; Hannibal L & D
Diagnosis: Epidermoid cyst
Submitter: ORSANCO Survey
RTLA 1543. Channel catfish, Ictalurus punctatus
Material: Skin lesion removed from lower jaw
Habitat: Ohio River; Hannibal L & D
Diagnosis: Inflammation of the dermis
Submitter: ORSANCO Survey
RTLA 1544. Bullhead, Ictalurus sp.
Material: Caudal fin with pigmented spot
Habitat: Ohio River; Hannibal L & D
Diagnosis: Partially sloughed epidermis allowed basal melanin layer
to show through
Submitter: ORSANCO Survey
RTLA 1545. Channel catfish, Ictalurus punctatus
Material: An opaque eye
Habitat: Ohio River; Hannibal L & D
Diagnosis: Inflammation and fibrosis of anterior chamber
Submitter: ORSANCO Survey
RTLA 1546. Carp, Cyprinus carplo
Material: Two opaque eyes
Habitat: Ohic l^vei , Hannibal L & D
Diagnosis: Paraorbital hemorrhage
Submitter: ORSANCO Survey
RTLA 1547. Mirror scale carp, Cyprinus carpio
Material: Right pectoral fin with pigmented spot
Habitat: Ohio River; Hannibal L & D
-23"
RTLA 1547 (contd.)
Diagnosis: Inf lamination and epideraal exfoliation due to bacterial
infection
Submitter: ORSANCO Survey
RTLA 1548. Channel catfish ^ Ictalurus punctatus
Material: Liver lesions
Habitat: Ohio River; Hannibal L & D
Diagnosis: Helminthic and protozoan granulomas
Submitter: ORSANCO Survey
RTLA
1549. Carp
Material :
Habitat :
Diagnosis :
Submitter:
Cyprinus carpio
Liver lesion
Ohio River; Hannibal L &
Granuloma
ORSANCO Survey
D
RTLA
1550. Carp
Material :
Habitat :
Diagnosis :
Submitter :
, Cyprinus carpio
Skin lesions on both sides of the
Ohio River; Pike Island L & D
Not processed
ORSANCO Survey
caudal peduncle
RTLA 1551. Spotted bass, Mlcropterus punctulatus
Material: A small piece of oral mucosa with plaque
Habitat: Ohio River; Pike Island L & D
Diagnosis: Ulcerative inflammatory reaction containing bacteria
Submitter: ORSANCO Survey
RTLA
1552. Carp,
Material:
Habitat :
Diagnosis :
Submitter:
Cyprinus carpio
Operculum with hemorrhagic raised plaque
Ohio River; Pike Island L & D
Epidermal papilloma
ORSANCO Survey
RTLA
1553. Carp,
Material :
Habitat:
Diagnosis :
Submitter:
Cyprinus carpio
Right operculum with protrusion on posterior edge
Ohio River; Pike Island L & D
Bone deformity associated with an old fracture
ORSANCO Survey
RTLA 1554. Mimic shiner, Notropis volucellus
Material: One gross specimen with a lesion near the vent
Habitat: Ohio River; Pike Island L & D
Diagnosis: Helminthic granuloma and ectopic fat
Submitter: ORSANCO Survey
RTLA 1555. Brown bullhead, Ictalurus nebulosus
Material: A portion of body wall with spots and mucus-like patches
on skin
Habitat: Ohio River; Belleville L & D
Diagnosis: Epidermis containing large numbers of alarm cells and
goblet cells
RTLA 1555 (contd.)
Submitter: ORSANCO Survey
-24-
RTLA 1556. Gizzard shad, Dorosoma cepedianum
Material: A lump
Habitat: Ohio River; Belleville L & D
Diagnosis: Not processed
Submitter: ORSANCO Survey
RTLA 1557. Brown bullhead, Ictalurus nebulosus
Material: A piece of body wall with crater-like (eroded) lesions
on the skin
Habitat: Ohio River; Belleville L & D
Diagnosis: Inflammation and ulceration of skin; atrophy of adjacent
muscle
Submitter: ORSANCO Survey
RTLA 1558. Channel catfish, Ictalurus punctatus
Material: A piece of body wall with skin lesions
Habitat: Ohio River; Belleville L & D
Diagnosis: Tissue on slides not diagnostic
Submitter: ORSANCO Survey
RTLA 1559. Channel catfish, Ictalurus punctatus
Material: Two pieces of tissue (red lesions on belly)
Habitat: Ohio River; Gallipolis L & D
Diagnosis: Ulcerative, hemorrhagic, inflammatory reaction
Submitter: ORSANCO Survey
RTLA 1560. Flathead catfish, Pylodictis olivaris
Material: A piece of tissue probably removed from the upper jaw
because of discoloration
Habitat: Ohio River; Meldahl L & D
Diagnosis: Ulcerated, inflammatory reaction
Submitter: ORSANCO Survey
RTLA 1561. Flathead catfish, Pylodictis olivaris
Material: A small piece of body wall with a small.
Habitat: Ohio River; Meldahl L & D
Diagnosis: Tissue on slides not diagnostic
Submitter: ORSANCO Survey
oval, flat lesion
RTLA 1562. Flathead catfish, Pylodictis olivaris
Material: Lump in body wall
Habitat: Ohio River; Meldahl L & D
Diagnosis: Demi inflammatory reaction
Submitter: ORSANCO Survey
RTLA 1563. Flathead catfish, Pylodictis olivaris
Material: Liver with several black pigmented areas
Habitat: Ohio River; Meldahl L & D
Diagnosis: Hemosiderosis
Submitter: ORSANCO Survey
^25™
RTLA 1564. Channel catfish, Ictalurus punctatus
Material: Two pieces of tissue; upper jaw lesion
Habitat: Ohio River; Meldahl L & D
Diagnosis: Ulcerated, inflanmatory reaction
Submitter: ORSANCO Survey
RTLA 1565. Channel catfish, Ictalurus punctatus
Jfaterial: Fatty nodules
Habitat; Ohio River; Meldahl L & D
Diagnosis: Lymphocystis
Submitter; ORSANCO Survey
RTLA 1566. Carp, Cyprinus carplo
Material; Protruding growth below eye
Habitat; Ohio River; McApline L & D
Diagnosis: Bone deformity
Submitter: ORSANCO Survey
RTLA 1567. Gizzard shad, Dorosoma cepedlanum
Material: White muscle-like tissue surrounding the right pelvic
fin; fin spines protrude through the growth
Habitat: Ohio River; McApline L & D
Diagnosis; Edematous, inflanmatory reaction
Submitter: ORSANCO Survey
RTLA 1568. Grapple, Pomoxis sp.
Material; Gross specimen with lymphocystis-
on anal and caudal fins
Habitat; Ohio River; McApline L & D
Diagnosis; Lymphocystis
Submitter: ORSANCO Survey
(tapioca) like growth
RTLA
1569. Carp
Material:
Habitat :
Diagnosis ;
Submitter I
» Cyprinus carpio
An eye completely occluded
Ohio River; Markland L & D
Eye replaced by multiple granulomas
ORSANCO Survey
RTLA 1570. Carp
Material :
Habitat ;
Diagnosis :
Submitter i
Cyprinus carplo
Eye socket with missing orbit
Ohio River; Markland L & D
Fatty replacement
ORSANCO Survey
RTLA 1571. Carp, Cyprinus carplo
Material: Darkly pigL er.ted lesion from behind the operculum
Habitat: Ohio River; Markland L & D
Diagnosis: Not processed
Submitter; ORSANCO Survey
RTLA 1572. Carp, Cyprinus carplo
Material: Two pieces of tissue; both appear to be eye remnants
Habitat: Ohio River; Markland L & D
-26-
RTLA 1572 (contd.)
Diagnosis: Inflammatory reaction
S ubmi 1 1 e r : ORS ANCO S urvey
RTLA 1573. Channel catfish, Ictalurus punctatus
Material: Slightly raised milky skin on lower jaw
Habitat: Ohio River; Gallipolis L & D
Diagnosis: Granuloma
Submitter: ORSANCO Survey
RTLA 1574. Channel catfish, Ictalurus punctatus
Material: Flush black spot on lower jaw
Habitat: Ohio River; Gallipolis L & D
Diagnosis: Epidermal hyperplasia associated with chronic inflammatory
reaction
Submitter: ORSANCO Survey
RTLA 1575. Brown bullhead, Ictalurus nebulosus
Material: Gross specimen with rugose growth on the upper lip; the
growth extended inside the mouth
Habitat: Ohio River; Belleville L & D
Diagnosis: Epidermal papilloma
Submitter: ORSANCO Survey
RTLA 1576. Channel catfish, Ictalurus punctatus
Material: A large piece of body wall with minute,
splotches
Habitat: Kanawha River; Winfield L & D
Diagnosis: Dermal papillae reach surface, normal
Submitter: ORSANCO Survey
flush, dark
RTLA 1577. Channel catfish, Ictalurus punctatus
Material: Liver with white lesions
Habitat: Kanawha River; Winfield L & D
Diagnosis: Multiple granulomas
Submitter: ORSANCO Survey
RTLA 1578. Channel catfish, Ictalurus punctatus
Material: Hemorrhagic liver
Habitat: Kanawha River; Winfield L & D
Diagnosis: Granuloma
Submitter: ORSANCO Survey
RTLA 1579. Channel catfish, Ictalurus punctatus
Material: White, mottled, dome-shaped bodies in kidney
Habit ax ; Kanawha River; Winfield L & D
Diagnosis: Normal stannius bodies
Submitter: ORSANCO Survey
RTLA 1580. Channel catfish, Ictalurus punctatus
Material: Multiple, white, dome-shaped lesions in the liver
Habitat: Kanawha River; Winfield L & D
Diagnosis: Helminthic granulomas
-27-
RTLA 1580 (contd.)
Submitter: ORSANCO Survey
RTLA 1581. Channel catfish, Ictalurus punctatus
Habitat :
Diagnosis :
Submitter:
Kanawha River;
Normal
ORSANCO Survey
Winfield L & D
RTLA 1582. Channel catfish, Ictalurus punctatus
Material: Liver and mesentery with 3 discrete,
lesions embedded in the liver
Habitat: Kanawha River; Winfield L & D
Diagnosis: Multiple granulomas
Submitter: ORSANCO Survey
white, dome-shaped
RTLA 1583. Carp, Cyprinus carpio
Material: Unattached mass from under swim bladder, near kidney
Habitat: Kanawha River; Winfield L & D
Diagnosis: Dry abscess containing bacteria
Submitter: ORSANCO Survey
RTLA 1584. Channel catfish, Ictalurus punctatus
Material: Liver with multiple, discrete, white lesions; liver
also pale around edges
Habitat: Kanawha River; Winfield L & D
Diagnosis: Granulomas
Submitter: ORSANCO Survey
RTLA 1585. Spotted sucker, Minytrema melanops
Material: Liver with very slight darkening in lobe
Habitat: Kanawha River; Winfield L & D
Diagnosis: Helminthic granulomas in mesentery
Submitter: ORSANCO Survey
RTLA 1586. Smallmouth buffalo, Ictiobus bubalus
Material: Liver
Habitat: Ohio River; Cannelton L & D
Diagnosis: Tissue on slides not diagnostic
Submitter: ORSANCO Survey
RTLA 1587. River carpsucker, Carpiodes carpio
Material: Fish head with small, white nasal protrusion
Habitat: Ohio River; Cannelton L & D
Diagnosis: Cartilaginous metaplasia of connective tissue associated
with mJerl^_ng parasitic granulomas
Submitter: ORSANCO Survey
RTLA 1588. Carp, Cyprinus carpio
Material: A dome-shaped bony projection from the hard palate
Habitat: Ohio River; Cannelton L & D
Diagnosis: Abnormal osseous projection of palatine bone
Submitter: ORSANCO Survey
-28-
RTLA 1589. Channel catfish, Ictalurus punctatus
Material :
Habitat :
Diagnosis :
Submitter:
Caudal peduncle with a white, dome-shaped protrusion
Ohio River; Cannelton L & D
Protozoan cyst
ORSANCO Survey
RTLA 1590. White catfish, Ictalurus catus
Material :
Habitat :
Diagnosis :
Submitter:
Liver with a small protrusion
Ohio River; Cannelton L & D
Multiple helminthic granulomas
ORSANCO Survey
RTLA 1591. Channel catfish, Ictalurus punctatus
Material :
A piece of body wall with flush, white blemishes in
the skin
Habitat :
Diagnosis :
Submitter:
Ohio River; Cannelton L & D
Patches of intradermal, chronic, inflammatory reaction
ORSANCO Survey
RTLA 1592. Channel catfish, Ictalurus punctatus
Material :
Liver and mesentery with several discrete, oval, white
growths
Habitat :
Diagnosis :
Submitter:
Ohio River; Cannelton L & D
Multiple granulomas
ORSANCO Survey
RTLA 1593. Buffalo, Ictiobus sp.
Material :
Posterior portion of fish with a palpable lump in muscle
dorsal to lateral line, anterior to caudal fin
Habitat :
Diagnosis :
Submitter:
Ohio River; Uniontown L & D
Hyperplastic nodule of metabolic fat
ORSANCO Survey
RTLA 1594. Buffalo, Ictiobus sp
Material:
Posterior portion of fish with a palpable lump in muscle
dorsal to lateral line, anterior to caudal fin
Habitat :
Diagnosis :
Submitter :
Ohio River; Uniontown L & D
Not processed
ORSANCO Survey
RTLA 1595. Carp, Cyprinus carpio
Material:
Habitat :
Diagnosis :
Submitter :
Liver with multiple minute black spots
Ohio River; Uniontown L & D
Multiple granulomas
ORSANCO Survey
RTLA 1596. Paddlefish, Polyodon spathula
Material :
Habitat :
Diagnosis :
Submitter:
Gastric caeca from two fish with raised, multiple lumps
Ohio River; Uniontown L & D
Helminthic granulomas in muscularis
ORSANCO Survey
RTLA 1597. White catfish, Ictalurus catus
„29~
RTLA 1597 (contd.)
Material: Liver with white lesions
Habitat :
Diagnosis :
Submitter :
Ohio River; Dashfield L & D
Helminthic granulomas
ORSANCO Survey
RTLA 1598. Coho
Material:
Habitat :
Diagnosis :
Submitter :
salmon, Oncorhynchus kisutch
Two microscope slides
Strait of Georgia, Canada
Neurofibroma
G. R. Bell
-30-
INDEX OF NEOPLASM - ANIMAL GROUP - AND RTLA NUMBER
Carcinoma situ: Fish - 1488
Cholangioma: Fish - 1426
Fibroblastic sarcoma: Reptile - 1400
Fibrolipoma: Fish - 1398
Fibroma: Fish - 1397
Fibrosarcoma: Fish - 1468, 1522
Germinoma: Mollusk - 1453-1458, 1500, 1501, 1503, 1505, 1507-1510, 1513
Hematopoietic neoplasm: Mollusk - 1392, 1413; Fish - 1399, 1442, 1519;
Arthropod - 1489, 1490; Reptile - 1385, 1499
Hepatoblastoma: Fish - 1469
Hepatoma: Fish - 1395, 1471
Leiomyoma: Fish - 1425
Leiomyosarcoma: Fish - 1475
Lipoma: Fish - 1518
Liposarcoma: Fish - 1470, 1473
Melanosarcoma: Fish - 1495
Mesenchymal sarcoma: Mollusk - 1435
Mesothelioma: Fish - 1485
Myxofibroma: Fish - 1494
Nephroblastoma: Fish - 1446, 1526
Neurilemmal sarcoma: Fish - 1401, 1476, 1477, 1492
Neurilemmoma: Fish - 1393, 1436, 1481, 1493, 1496
N_urolj.oroma: Fish - 1598
Osteocartilaginous exostoses: Reptile - 1386
Osteochondroma: Fish - 1528
Osteoma: Fish - 1384
-31-
Pancreatic adenocarcinoma: Reptile - 1387
Papillary epithelial neoplasm: Reptile - 1388, 1389, 1524; Fish - 1390, 1434,
1440, 1486, 1487, 1516, 1517, 1552, 1575
Parathyroid adenoma: Reptile - 1402
Renal tubular carcinoma: Fish - 1526
Rhabdomyoma: Fish - 1477
Sarcoma: Fish - 1407
Squamous carcinoma: Reptile - 1437
Teratoma: Fish - 1425
Thyroid adenoma: Fish - 1439
Thyroid hyperplasia (colloid goiter) : Fish - 1525
Vesicular connective tissue neoplasm: Mollusk - 1474
-32-
PHYLOGENETIC INDEX
PHYLUM CHORDATA
Class Reptilia
Order Chelonla (turtles) - RTLA 1388, 1402, 1420, 1429, 1437
Order Squamata (lizards, snakes) - RTLA 1385-1387, 1389, 1400,
1403, 1404, 1408-1411, 1419, 1421, 1422, 1424, 1427, 1428,
1499, 1524
Class Amphibia
Order Anura (toads, frogs) - RTLA 1520, 1523
Class Osteiohthyes
Order Acipenseriformes (sturgeons) - RTLA 1596
Order Anguilliformes (eels) - RTLA 1440
Order Clupeiformes (herrings, anchovies) - RTLA 1480, 1529, 1538,
1556, 1567
Order Salmoniformes
Family Salmonidae (salmon, trout, whitefish, cisco) - RTLA
1397-1399, 1407, 1423, 1426, 1430, 1431, 1441, 1443, 1446,
1462, 1468, 1469, 1475-1477, 1488, 1491-1494, 1519, 1522,
1598
Family Esocidae (pikes) - RTLA 1442
Order Cyprinlf ormes (suckers, goldfish, carp, minnows, roaches,
scissorstail) - RTLA 1393, 1395, 1405, 1425, 1436, 1445, 1447,
1470, 1473, 1485, 1531, 1532, 1536, 1546, 1547, 1549, 1550,
1552-1554, 1566, 1569-1572, 1583, 1585, 1586-1588, 1593-1595
Order Siluriformes (catfish, bullheads) - RTLA 1496, 1533-1535,
1537, 1539-1545, 1548, 1555, 1557-1565, 1573-1582, 1584,
1589-1592, 1597
Order At her inif ormes (killifish, platys, needlefish, mollies, top
minnows) - RTLA 1525
Order Perciformes
Family Centrarchidae (sunfishes, bass, crappies) - RTLA 1394
1527, 1528, 1530, 1551, 1568
-33-
Family Carangidae (jacks, pompanos) - RTLA 1484
Family Lutjanidae (snappers) - RTLA 1481
Family Sparidae (porgies, pinfish) - RTLA 1478, 1479
Family Sciaenldae (drums, croakers) - RTLA 1482, 1521
Family Chaetodontidae (butterf lyf ishes) - RTLA 1439
Family Cichlldae (cichlids) - RTLA 1526
Family Labridae (wrasses) - RTLA 1434
Family Scombridae (mackerels, tunas, bonito) - RTLA 1384, 1483,
1518
Order Pleuronectiformes (sole, flounders, sanddabs, halibut) - RTLA
1390, 1433, 1487, 1516, 1517
Order Tetraodontif ormes (trigger! ishes , filef ishes) - RTLA 1466
Not classified - RTLA 1401, 1463-1465, 1467, 1471, 1486,
1495, 1516, 1517
Class Chondpiohthyes
Order Squallformes (sharks) - RTLA 1412
SUBPHYLUM TUNIC ATA - RTLA 1406
PHYLUM ARTHROPODA
Class Inseota - RTLA 1489, 1490
PHYLUM ANNELIDA
Class Oligoohaeta (earthworms) - RTLA 1432, 1472
PHYLUM MOLLUSCA
Class Blvalvia (mussels, clams, scallops, oysters) - RTLA 1391, 1392,
1396, 1413-1418, 1435, 1438, 1444, 1448-1461, 1474, 1497, 1498,
1500-1515
-34-
INDEX OF SPECIMENS BY SCIENTIFIC AND COMMON NAMES
RTLA NUMBER
A
African lungfish 1495
Albacore 1384
Amblema plicata 1396
American anole 1427
American oyster 1435, 1444
Amphlprion ocellaris 1463-1465
Anolls carolinensls 1427
Artica islandica 1392
Asiatic clam 1391
Atlantic bonito 1483
B
Banded cichlid
Black bullhead
Black drum
Black quahog
Blue gourami
Bluefin tuna
Bluegill
Bluntnose minnow
Brevoortia sp.
Brevoortia patronus
Brook trout
Brown bullhead
Brown trout
Buffalo
Bufo marinus
Bullhead
Bullsnake
Butterf lyf ish
1526
1496
1482
1392
1401
1518
1530
1445
1480
1529
1519
1555, 1557, 1575
1476, 1477
1593, 1594
1523
1544
1424
1439
California moray
Carassius auratus
Carp
Carpiodes carpio
Catfish
Catostomus macrocheilus
Channel catfish
Chelmon rostratus
1440
1393, 1436
1425, 1485, 1531, 1532, 1546,
1549, 1550, 1552, 1553, 1566,
1569-1572, 1583, 1588, 1595
1587
1537
1395
1540-1543, 1545, 1548, 1558, 1559,
1564, 1565, 1573, 1574, 1576-
1582, 1584, 1589, 1591, 1592
1439
-35-
RTLA NUMBER
Chinook salmon
Chrysemys scripta elegans
Clchlasoma severum
Cisco
Clemmys sp,
Clemmys marmorata
Clownf ish
Coho salmon
Common shiner
Corbicula fluminea
Coregonus artedii
Crappie
Crassostrea virginica
Cyprinus carpio
1441, 1522
1437
1526
1426
1388
1420, 1429
1463-1465
1407, 1468, 1598
1447
1391
1426
1568
1435, 1444
1425, 1485, 1531, 1532, 1546, 1547,
1549, 1550, 1552, 1553, 1566,
1569-1572, 1583, 1588, 1595
Dascyllus trimaculatus
Dolly Varden
Dorosoma cepedianum
Dover sole
Drosophila melanogaster
E
1467
1494
1538,
1390
1489,
1556, 1567
1490
Earthworm
Esox lucius
1432, 1472
1442
F
Fathead minnow
Flathead catfish
Florida pompano
Fundulus maj alls
1470, 1473
1539, 1560-1563
1484
1525
Galeocerdo cuvieri
Gizzard shad
Goldfish
Great Basin gopher snake
G'"e:k tcrtoise
Green lizard
Gulf menhaden
Gymno thorax mordax
1412
1538, 1556, 1567
1393, 1436
1400
1402
1389, 1524
1529
1440
H
Halocynthia pyriformis
1406
-36-
Hard-Shell clam
Hemigrannus rhodostomus
Hippoglossus stenolepis
RTLA NUMBER
1414-1418, 1438, 1497, 1498
1405
1433
Ictalurus sp.
Ictalurus catus
Ictalurus melas
Ictalurus nebulosus
Ictalurus punctatus
Ictlobus sp.
Ictiobus bubalus
Iguana iguana
Indian monitor lizard
1544
1533-1535, 1590, 1597
1496
1555, 1557, 1575
1540-1543, 1545, 1548, 1558, 1559
1564, 1565, 1573, 1574, 1576-
1582, 1584, 1589, 1591, 1592
1593, 1594
1586
1385, 1403, 1404, 1408-1411, 1419
1421, 1422, 1428
1386, 1499
K
Kareius bicoloratus 1486
L
Lacerta viridis
Lagodon rhomboides
Lahontan cutthroat trout
Lake trout
Largemouth bass
Largescale sucker
Leiostomus xanthurus
Lepomis macrochirus
Lepomis megalotis
Limanda schrenki
Longear sunfish
Lutj anus griseus
M
1389, 1524
1478, 1479
1399
1398
1527, 1528
1395
1521
1530
1394
1516, 1517
1394
1481
Mangrove snapper
Marine toad
Medaka
Menhaden
Mercenaria mercenaria
Micropterus punctulatus
Micropterus salmoides
Microstomus pacif icus
Mimic shiner
Minnow
1481
1523
1471
1480
1414-1418, 1438, 1497, 1498
1551
1527, 1528
1390
1554
1536
RTLA NUMBER
Minytrema melanops
Mirror scale carp
Monacanthus hispidus
Montana grayling
Mt. Whitney rainbow trout
Mussel
Mya arenarla
My til us sp.
N
Northern pike
Notropis comutus
Notropis volucellus
0
Oncorhynchus kisutch
Oncorhynchus nerka
Oncorhynchus tschawytscha
Oryzias latipes
P
Pacific halibut
Pacific pond turtle
Paddlefish
Pimephales notatus
Pimephales promelas
Pinfish
Pituophis melanoleucus
Pituophis melanoleucus deserticola
Planehead filefish
Platichthys stellatus
Pogonias cromis
Polyodon spathula
Pomoxls sp .
Protopterus dolloi
Pylodictis olivaris
R
Rainbow trout
Red-eared turtle
River carpsucker
Rummy nose tetra
_S
Salmo dark!
1585
1547
1466
1462
1430, 1431
1474
1413, 1448-1461, 1500-1515
1474
1442
1447
1554
1407, 1468, 1598
1475, 1492, 1493
1441, 1522
1471
1433
1420, 1429
1596
1445
1470, 1473
1478, 1479
1424
1400
1466
1487
1482
1596
1568
1495
1539, 1560-1563
1397, 1423, 1443, 1446, 1469,
1488, 1491
1437
1587
1405
1399
-38-
Salmo gairdneri
Salmo trutta
Salvellnus fontinalis
Salvellnus malma
Salvelinus namaycush
Sarda sarda
Sea peach
Smallmouth buffalo
Sockeye salmon
Soft-shell clam
South African clawed frog
Spllotes sp.
Spot
Spotted bass
Spotted sucker
Starry flounder
Striped killifish
T
Tautog
Tautoga onitis
Testudo graeca
Three-ridge naiad
Three-spot damsel
Thunnus alalunga
Thunnus thynnus
Thymallus arcticus
Tiger shark
Trachinotus carolinus
Trichogaster trichopterus sumatranus
V
Varanus bengalensis
W
White catfish
RTLA NUMBER
1397, 1423, 1430, 1431, 1443,
1446, 1469, 1488, 1491
1476, 1477
1519
1494
1398
1483
1406
1586
1475, 1492, 1493
1413, 1448-1461, 1500-1515
1520
1387
1521
1551
1585
1487
1525
1434
1434
1402
1396
1467
1384
1518
1462
1412
1484
1401
1386, 1499
1533-1535, 1590, 1597
X
Xenopus laevis
1520
. -39-
contributors
ANDERSON, R. S.
Donald S. Walker Laboratory
Sloan-Kettering Institute for
Cancer Research
145 Boston Post Road
Rye, New York 10580
RTLA 1406
ARMSTRONG, D.
Land, Air, Water Resources (LAWR)
University of California
Davis, California 95616
RTLA 1432
BECKER, C. D.
Ecosystems Department
Battelle Pacific Northwest
Laboratories
Battelle Boulevard
Richland, Washington 99352
RTLA 1395, 1496
BELL, G. R.
Pacific Biological Station
P. 0. Box 100
Nanaimo, B. C., V9R 5K6, Canada
RTLA 1475, 1492, 1493, 1598
BROWN, R.
Agricultural Experiment Station
Department of Animal Pathology
University of Rhode Island
Kingston, Rhode Island 02881
RTLA 1413
CARPENTER, D. 0.
Neurobiology Department
Armed Forces Radiobiology
Research Institute
Defense Nuclear Agency
Bethesda, Maryland 20014
RTLA 1401
CHANG, S. C.
Registry of Tumors in
Lower Animals
National Museum of Natural History
Room W216“a
Smithsonian Institution
Washington, D. C. 20560
RTLA 1414-1418, 1438, 1497, 1498
COOPER, E, L.
Department of Anatomy
School of Medicine
University of California
Los Angeles, California 90024
RTLA 1432
COSGROVE, G. E.
Biology Division
Oak Ridge National Laboratory
P. 0. Box Y
Oak Ridge, Tennessee 37830
RTLA 1472, 1520
COWDEN, R. R.
College of Medicine
East Tennessee State University
Johnson City, Tennessee 37601
RTLA 1393
DOYLE, W. L.
Department of Anatomy
University of Chicago
1025 East 57th Street
Chicago, Illinois 60637
RTLA 1474
FRYE, F. L.
235 Willamette Avenue
Kensington, California 94708
RTLA 1385-1388, 1402-1404, 1408-1411,
1419-1422, 1428, 1429, 1437
GATEFF, E.
Biologisches Institut I (Zoologie) der
Albert-Ludwigs-Universitat
Schanzlestrasse 9
78 Freiburg IM Breisgau, West Germany
RTLA 1489, 1490
GEORGE, C. J.
Department of Biological Sciences
Union College
Schenectady, New York 12308
RTLA 1426
GILFILLAN, E.
Bigelow Laboratory for Ocean Sciences
McKown Point
West Boothbay Harbor, Maine 04575
RTLA 1500-1515
-40-
GRIZZLE, J.
Department of Fisheries and
Allied Aquacultures
School of Agriculture and
Agricultural Experiment
Station System
Auburn University
Auburn, Alabama 36830
RTLA 1445, 1525-1530
GUARINO, A.
Laboratory of Toxicology
National Cancer Institute, NIH
Building 37, Room 5B-22
Bethesda, Maryland 20014
RTLA 1474
HAMM, T. E.
Medical Center
University of Colorado
4200 East 9th Avenue
Denver, Colorado 80262
RTLA 1424
HARADA, T.
Faculty of Fisheries
Hokkaido University
Hakodate, Japan
RTLA 1487, 1517
HARSHBARGER, J. C.
Registry of Tumors in
Lower Animals
National Museum of Natural History
Room W216-a
Smithsonian Institution
Washington, D. C. 20560
RTLA 1414-1418, 1438, 1497, 1498
HENDRICKS, J. D.
Department of Food Science and
Technology
Oregon State University
Corvallis, Oregon 97331
RTLA 1384
HERWIG, N.
San Antonio Zoological Gardens
and Aquarium
3903 North St. Mary’s Street
San Antonio, Texas 78212
RTLA 1405, 1495
HINE, P. M.
Fisheries Research Division
Ministry of Agriculture and Fisheries
P. 0. Box 19062
Wellington, New Zealand
RTLA 1441
HINK, W. F.
Department of Entomology
Ohio State University
Columbus, Ohio 43210
RTLA 1396
HNATH, J. G.
Pathobiology Laboratory
Wolf Lake Fish Hatchery
Michigan Department of Natural
Resources
Route #1
Mattawan, Michigan 49071
RTLA 1423, 1522
HOSKINS, G. E.
Pacific Biological Station
P. 0. Box 100
Nanaimo , B . C . , V9R 5K6 , Canada
RTLA 1407, 1433, 1442, 1468, 1494
HURST, J.
Maine Department of Marine Resources
West Boothbay Harbor, Maine 04575
RTLA 1448-1461
ISHIKAWA, T.
Department of Experimental Pathology
Cancer Institute
Kami-Ikebukuro , Toshima-ku
Tokyo 170, Japan
RTLA 1471
JACKSON, 0. F.
Royal Free Hospital School of Medicine
University of London
8 Hunter Street
London, WCIN IBP, England
RTLA 1389, 1524
KANDRASHOFF, W.
951 Euclid Avenue
Miami Beach, Florida 33139
RTLA 1478-1485
-41»
LAGIOS, M. D.
Department of Pathology
Children's Hospital of San Francisco
P. 0. Box 3805
San Francisco, California 94119
RTLA 1439, 1440
MCQUAY, F.
Towson, Maryland 21204
RTLA 1427
MILLER, E. K.
Palms of Pasadena Hospital
P. 0. Box 6158
1501 Pasadena Avenue South
St. Petersburg, Florida 33736
RTLA 1463-1467
MORTON, B. S.
Department of Zoology
University of Hong Kong
Pokfulam Road
Hong Kong
RTLA 1391
OBDEYN, I. M.
Regentesselaan 17
Amersfoort, The Netherlands
RTLA 1436
OISHI, K.
Faculty of Fisheries
Hokkaido University
Hakodate, Japan
RTLA 1486, 1516
ORSANCO
W. L. Klein
Ohio River Valley Water Sanitation
Commission
414 Walnut Street
Cincinnati, Ohio 45202
RTLA 1531-1597
OTTO, SARA V.
State Laboratory
Maryland Department of Natural
Resources
Oxford, Maryland 21654
RTLA 1414-1418, 1438, 1444, 1497,
1498
PENDLEBURY, G. B.
304 Manora Road, Northeast
Calgary, Alberta, T2A 4R6, Canada
RTLA 1400
PENG, J.
National Cancer Institute, NIH
Building 10, Room 6B-10
Bethesda, Maryland 20014
RTLA 1521
SHERWOOD, M. J.
Southern California Coastal Water
Research Project
1500 East Imperial Highway
El Segundo, California 90245
RTLA 1390
SHIVELY, J. N.
Department of Veterinary Science
College of Agriculture
University of Arizona
Tucson, Arizona 85721
RTLA 1499
SIGEL, M. M.
Department of Microbiology
University of Miami School of
Medicine
P. 0. Box 520875, Biscayne Annex
Miami, Florida 33152
RTLA 1412
SMITH, C. E.
Fish Cultural Development Center
U.S. Department of the Interior
Route 2, Box 333
Bozeman, Montana 59715
RTLA 1397-1399, 1462, 1469, 1470,
1473, 1488, 1491
SMITH, C. L.
Department of Ichthyology
The American Museum of Natural History
Central Park West at 79th Street
New York, New York 10024
RTLA 1447
SMITH, W. E.
National Water Quality Laboratory
U.S. Environmental Protection Agency
6201 Congdon Boulevard
Duluth, Minnesota 55804
RTLA 1394
-42-
STEIN, C. B.
Museum of Zoology
Ohio State University
1813 North High Street
Columbus, Ohio 43210
RTLA 1396
STEIN, E.
Department of Anatomy
School of Medicine
University of California
Los Angeles, California 90024
RTLA 1432
STEVENSON, B,
Palmerston North Animal Health Laboratory
Palmerston North, New Zealand
RTLA 1476, 1477
WARD, J. M,
Laboratory of Toxicology
National Cancer Institute, NIH
Building 37, Room 5B-22
Bethesda, Maryland 20014
RTLA 1474
WOLF, H.
Fish Disease Laboratory
California Department of Fish and Game
2111 Nimbus Road
Rancho Cordova, California 95670
RTLA 1430, 1431, 1443, 1446
WOLKE, R. E.
Seagrant Pathology Laboratory
University of Rhode Island
Kingston, Rhode Island 02881
RTLA 1425, 1434
YEVICH, P. P.
Environmental Research Laboratory
U.S. Environmental Protection Agency
South Ferry Road
Narragansett , Rhode Island 02882
RTLA 1392, 1435, 1518, 1519
ZUG, G, R.
Division of Reptiles and Amphibians
National Museum of Natural History
Room W-205
Smithsonian Institution
Washington, D. C. 20560
RTLA 1523
TEAR OUT ACCESSION SHEET
PLEASE SUBMIT TOs
Dr* John C. Harshbarger
Registry of Tumors in Lower Animals
National Museum of Natural History
Room W216-A
Smithsonian Institution
Washington, D.C., 20560, USA
DATE RECD« _ _ _
CONTRIBUTOR'S NO,
RTLA NO, _____
USNM NO. _ _
NIH HISTOPATH NO.
COMMON NAME _ _ _ _ FAMILY _ _ _ _
PHYLUM _ _ _ _ genus _ _ _
CLASS _ _ _ _ SPECIES _ _ _
ORDER _ _ _ _ _
CATEGORY: NEOPLASM _ _ INFLAMMATION _ INFECTION _ PARASITIC
DEVELOPMENTAL _ TRAUMATIC _ NORMAL _ _ OTHER _ _
CONTRIBUTOR (NAME & ADDRESS): COLLECTOR (NAME & ADDRESS):
TOXIC
ITEMS SUBMITTED (QUANTITY):
GROSS MATERIAL _ _ _ PHOTOGRAPHS _ _
SLIDES _ _ _ _ REPRINTS ___
BLOCKS _ _ _ _ OTHER _____
ORIGIN OF ANIMAL: MARINE _ FRESHWATER _ _ ESTAURINE
WHERE COLLEGTED _ _ _ _
TERRESTRIAL
date COLLECTED _______ SEX _ AGE _ STAGE OF LIFE CYCLE
HOW KILLED _ _ _ _ FIXATION _ _ _
GROSS DESCRIPTION _ _ _ _ _ _
MICROSCOPE DX
COMMENTS (e.g,, possible exposure to chemical pollutants or infectious agents, in¬
cidence and duration of this condition in the population, etc.)
(Please use reverse side, if more space is needed)
^ 1
V \
\ ;l
I,
\ '■
)
1
i
)
)
?
i
I
)
)
i
I
)
I
i
i
)
!
')
I
I
i
) J
1
ACTIVITIES REPORT
REGISTRY OF TUMORS IN LOWER ANIMALS
1977 SUPPLEMENT
JOHN C. HARSHBARGER, DIRECTOR
PREPARED FOR DISTRIBUTION BY:
REGISTRY OF TUMORS IN LOWER ANIMALS
NATIONAL MUSEUM OF NATURAL HISTORY
ROOM W216A
SMITHSONIAN INSTITUTION
WASHINGTON, D.C. 20560
S^'THSO/V^
JUL EiJ 1987
NIH Contract #N01-CB-33874: Contractor: Smithsonian Institution
ACTIVITIES REPORT
REGISTRY OF TUMORS IN LOWER ANIMALS
1977 SUPPLEMENT
JOHN C. HARSHBARGER, DIRECTOR
PREPARED FOR DISTRIBUTION BY;
REGISTRY OF TUMORS IN LOWER ANIMALS
NATIONAL MUSEUM OF NATURAL HISTORY
ROOM W216A
SMITHSONIAN INSTITUTION
WASHINGTON, D.C. 20560
NIH Contract #N01-CB-33874; Contractor; Smithsonian Institution
ejAHim mmj m a^oMin-
"fM
>iiOr:)3j3T(r .JraOMSHBHAH .D miOl.
: in mnmJSin ra .aaaA^^a^i^
a.iAMiJiA mioj M a^ioMTJT TO maioa^
y.iioa'2TH dMmm jo fn/aaim jawoxtaw
AvUSW MOOa
W.T'!Tr:’XT2WI KAIW08HTIM8
OdilOSj^ .O.a .t^OTOHX>i{iAW
I
'V'
nolJuOfiaaal n»inoaff3Jl«ia : TotcxiiUrroO j^>\Cil£C“ao-iOW*ft HIJi
CONTENTS
OVERVIEW . 1
TABLE I - DISTRIBUTION OF LESIONS AMONG
SPECIMENS ACCESSIONED . 2
REFERENCE LIBRARY . 4
PAPERS SINCE 1976 . 4
SELECTED OTHER ACTIVITIES IN 1977 . 5
PERSONNEL . 6
ACCESSIONS . 7
INDEX OF NEOPLASM - ^IMAL GROUP - AND
RTLA NUMBER . 31
PHYLOGENETIC INDEX . 33
INDEX OF SPECIMENS BY SCIENTIFIC AND
COMMON NAMES . 35
CONTRIBUTORS .... . . 40
TEAR OUT ACCESSION SHEET . Last page
Smithsonian Institution
Washington, D.C.
1978
OVERVIEW
The Registry of Tumors in Lower Animals facilitates the study of
neoplasms and related disorders in invertebrate and poikilotherraic ver¬
tebrate animals by serving as a specimen depository, a diagnostic cen¬
ter, an information center, and a research group.
Two hundred thirty-nine accessions were entered into the Registry's
permanent collection in 1977. As shown in Table I, slightly over one-
half were neoplasms which occurred, in decreasing numbers, in bivalve
mollusks, bony fish, amphibians, reptiles, and one shark.
Among the many interesting and significant cases received was an oys¬
ter contributed by John A. Couch (RTLA 1599) with both a Dermocystidium
marinum infection and the condition widely interpreted as a hematopoietic
neoplasm characterized by a diffuse infiltration of small, unassociated,
uniform, rapidly proliferating cells. This case, coupled with "Dermo"
only cases and "hematopoietic neoplasm" only cases, would seem to pro¬
vide conclusive evidence that the populations of proliferating, infil¬
trating cells known from at least six bivalve species are hematopoietic
neoplasms rather than a stage of Dermocystidium marinum as once proposed.
Other mollusks with neoplasms included Australian rock oysters from
Peter H. Wolf with mantle papillomas (RTLA 1608-1614, 1795); American
oysters from Sara V. Otto with hematopoietic neoplasms (RTLA 1749, 1750,
1752-1754, 1757-1761, 1765), undifferentiated sarcomas (RTLA 1763, 1764),
a germinoma (RTLA 1748), and cryptic adenomatous hyperplasias of the man¬
tle (RTLA 1751, 1755, 1756, 1762); European flat oysters from Paul van
Banning with hematopoietic neoplasms (RTLA 1808, 1809); a mussel from
David J. Alderman with a hematopoietic neoplasm (RTLA 1833) ; a scallop
with a possible hematopoietic neoplasm from Robert S. Brown (RTLA 1834);
and, soft-shell clams from Paul P. Yevich with germinomas from the Sears-
port, Maine, oil spill site (RTLA 1694-1703). With regard to soft-clam
germinomas, we recently found Intranuclear virus-like inclusions in the
tumor cells and Dr. Sing Chen Chang, the Registry's Electron Microscopist ,
is attempting to verify their viral nature. Thus, these germinomas may be
caused by a virus with possible activation and/or enhancement by stress
from petroleum hydrocarbons rather than by direct chemical carcinogenesis.
Mollusk accessions containing basophilic cytoplasmic inclusions, in¬
cluded soft-shell clams (RTLA 1620-1640), a hard-shell clam (RTLA 1766),
and American oysters (RTLA 1735, 1736) from Sara V. Otto; mussels from
Paul P. Yevich and Carolyn A. Barszcz (RTLA 1741-1743); and, a thin tellin
from James S. Buchanan (RTLA 1810). These inclusions have recently been
found to be very widespread and to represent infections by procaryotic
organisms such as chlamydiae, rickettsiae, and possibly mycoplasmas.
One possible shark neoplasm was received from S. Gruber, W. Riemer,
and M. Michael Sigel (RTLA 1836). The lesion was either an adenoma or
hyperplasia of probable thyroid origin in a nurse shark. Lack of a
definitive diagnosis was partly due to an unfamiliarity with the normal
histology.
DISTRIBUTION OF LESIONS AMONG SPECIMENS ACCESSIONED
-2-
S'?
6^
/— S
o
'0-
'Cf
rH
tH
I— 1
o
00
rH
fO
V
V
CSl
I— 1
Nw'
CO
u
o
'0-
rH
rH
iH
'0-
r~.
OS
O
CNI
ro
00
O'
H
CN
n3
0)
6^
02
Nt-
O
C
W
o
iH
CN
o
o
o
O
Not
dia
X
w
w
<
W ■
w
M
Q
Um
o
o
•H
w
4-)
/~s
(In
CO
CO
X
00
H
tH
<r
Ou
(U
tH
O
o\
o
iH
o-
<3-
C3S
c
1 — i
rH
m
■<}•
O
1
rH
fi
o
o
•H
S'?
4-)
o
CN
CO
LO
m
CO
I — I
o.
o^
fO
o
iH
o
o
rH
o
CN
'O-
CN
0)
I— 1
(U
CO
o
X
o
4J
•H
X
■U
B
4h 0)
CU
C
x:
u
T3
O CO
c
cO
CO
(U
O
o
(1)
CU
•H
•H
T3
CL
X
■U 3
too
r-H
4-1
O
o
CO
3 00
O &
•H
•H
3
3
3
rH
(U 3
.H 3
•U
x:
•H
X
rH
3
O ‘H
>> O
a
a
3
CO
XI
4J
rH
•U
3 TO
JZ U
B
O
x:
U
M
O
O
3
P-. M
<
PQ
c/2
w
c
s
H
Pl
-3-
Neoplasms of neural origin predominated the bony fish accessions
including three of only five central nervous system tumors ever received.
Peripheral nerve tumors included a ganglioneuroma in a weakfish from
D. E. Zwerner and Craig L. Ruddell (RTLA 1605); neurilemmomas/neurilemmal
sarcomas in carp from George C. Blasiola, Jr. (RTLA 1618) and Dave
Tomljanovich (RTLA 1747); in rainbow trout from Peter H. Wolf (RTLA 1642)
and Barry J. Stevenson (RTLA 1786), and in goldfish from Harold Wolf (RTLA
1643) and Robert Marino (RTLA 1771); a malignant melanophoroma in an aquar¬
ium catfish from June Herrin (RTLA 1647); a blue nevus in a trevally from
Barry J, Stevenson (RTLA 1694); and, a neural fibrosarcoma whose species
and contributor are unknown (RTLA 1658) . The central nervous system tu¬
mors v/ere a well-differentiated olfactory neuroepithelioma in a carp from
Prince Masahito Hitachi (RTLA 1707) and two ependymoblastomas in coho sal¬
mon, one from Gary E. Hoskins (RTLA 1783) and one from Jerry D. Hendricks
(RTLA 1811).
Renal neoplasms included nephroblastomas in a rainbow trout from
Harold Wolf (RTLA 1615), a rose bitterling from Prince Masahito Hitachi
(RTLA 1711), and a carp from George C. Blasiola, Jr. (RTLA 1775). Muscle
tumors included dramatic virus-containing leiomyosarcomas in swim bladders
of cultured Atlantic salmon from Ian J. McKnight and K. G. R. Elson (RTLA
1660); a leiomyoma in a brown trout from Barry J. Stevenson (RTLA 1651);
and, a rhabdomyosarcoma induced in a platyfish swordtail backcross hybrid
with N-methyl-N-nitroso-urea from M. Schwab (RTLA 1732). Dr. Schwab also
induced a fibrosarcoma in these hybrids with the same compound (RTLA 1733).
An undifferentiated spindle cell sarcoma in a chinook salmon from Barry J.
Stevenson (RTLA 1785) may be an embryonal rhabdomyoma. Huge cranial li¬
poma-like lesions, induced in fathead minnows with ammonia, were contri¬
buted by Charlie E. Smith (RTLA 1653-1657) and further experiments are
in progress to determine if they are neoplastic or hyperplastic. J. Pal
contributed a lipoma in a catfish (RTLA 1815) and Allyn G. Johnson con¬
tributed a lipoma in a finescale menhaden (RTLA 1664) and a two-pound
fibrolipoma in a drum (RTLA 1662). Lipomas in a porgy (RTLA 1718) and a
mojarra (RTLA 1730) were received from Walter Kandrashoff in a large batch
of specimens (RTLA 1714-1722, 1724-1730) from North Biscayne Bay, Florida.
The preponderance of lesions in the other fish in the batch were various
gross manifestations of acute and chronic inflammatory reactions, often
involving ulceration and/or parasites. Mr. Kandrashoff has seen an in¬
creasing prevalence of these conditions during the decade and feels that
this increased susceptibility to parasites is related to increased amounts
of organic chemicals going into the bay.
Hematopoietic neoplasms included malignant lymphomas in a rainbow
trout from Charlie E. Smith (RTLA 1814) and in a blackfin pearlfish from
George C. Blasiola, Jr. (RTLA 1646). Individual cases included a caver¬
nous hemangioma in a rainbow trout from Barry J. Stevenson (RTLA 1650),
a mesothelioma in a jewfish from Robert R. Shields (RTLA 1617), an epi¬
dermal papilloma in a climbing perch from Joydeb Pal (RTLA 1738), a car¬
cinoma possibly of ultimobranchial gland origin in a cutthroat trout from
Charlie E. Smith (RTLA 1837), a thyroid adenoma in a Kinubari from Prince
Masahito Hitachi (RTLA 1712), and an ichthyematoraa (fish scale tumor) in
a goldfish from Nelson Herwig (RTLA 1822). Over the years, we have re-
-4-
ceived at least three ichthyematomas or skin tumors in which pegs of epi¬
dermis are interacting with dermal connective tissue, similar to the pro¬
cess of tooth formation, resulting in variably differentiated levels of
scale production.
Among amphibians, 20 Mexican axolotl specimens contributed by Louis
E. DeLanney (RTLA 1674-1693) had one adenoma, one intradermal melano-
phoroma, and 18 very interesting cutaneous lesions primarily composed of
mast cells. The fine structure is currently being studied in an effort
to differentiate between the possibility these are mast cell tumors
versus nodules of mastocytosis. A transplanted melanophoroma in a tiger
salamander from Francis L. Rose (RTLA 1740) appeared to be viable. Two
hematopoietic neoplasms were accessioned from South African clawed frogs.
One, contributed by Gerry E. Cosgrove (RTLA 1665), was a lymphosarcoma.
The cell type of the other case, contributed by R. Verhoeff-de Fremery
(RTLA 1769), could not be determined.
Among reptiles were five snake neoplasms: a malignant lymphoma in
an Indian rock python from Phillip T. Robinson (RTLA 1600) , a lympho¬
sarcoma in a California king snake from Elliott Jacobson (RTLA 1770), an
oral squamous versus epidermoid sarcoma in a California king snake from
James R. Hill (RTLA 1835) , a lipoma in a boa constrictor from Fredric L.
Frye (RTLA 1823), and an angiosarcoma in a timber rattlesnake from Elliott
Jacobson and S. W. Nielsen (RTLA 1819), but which preliminary electron
microscopy suggests may actually be a carcinoma. Material from two green
sea turtles with cutaneous f ibropapillomas was received from George H.
Balazs (RTLA 1767, 1774). A wart-like epidermal papilloma containing
intranuclear inclusions in a green lizard was contributed by E. Elkan
(RTLA 1821).
REFERENCE LIBRARY
Approximately 360 papers were added to the comprehensive library on
neoplasms in lower animals bringing the total to 3,510. Except for re¬
cent acquisitions and articles that need to be translated, all papers have
been abstracted by selected key words and computerized.
PAPERS SINCE 1976
Harshbarger, J.C. The Role of the Registry of Tumors in Lower Animals in
the Study of Environmental Carcinogenesis in Aquatic Animals. Ann. N.Y.
Acad. Sci., 2^: 280-289. 1977.
Rose, F.L. and Harshbarger, J.C. Neoplastic and Possibly Related Skin
Lesions in Neotenic Tiger Salamanders, Ambystoma tigrinum, from a
Sewage Lagoon. Science, 196 : 315-317. 1977.
Harshbarger, J.C., Chang, S.C., and Otto, S.V. Chlamydiae (with Phages),
Mycoplasmas, and Rickettsiae in Chesapeake Bay Bivalves. Science, 196 :
666-668. 1977.
-5-
Anderson, R.S., Jordan, L.A. , and Harshbarger, J.C. Tunic Abnormalities
of the Urochordate Halocynthia pyriformis (Rathke) . J. Invertebr.
Pathol., 160-168. 1977.
Harshbarger, J.C. "Spontaneous Neoplasms in Amphibians" and "Spontaneous
Neoplasms in Reptiles," two Sections of Chapter 1: "Tumors," In:
Pathology of Laboratory Animals, Vol. 2, K. Benirschke, F.M. Garner,
T.C. Jones, and C. Kozma (ed. ) , (Springer-Verlag, New York; in press).
Harshbarger, J.C., Otto, S.V. , and Chang, S.C. Proliferative Disorders in
Crassostrea virginica and Mya arenaria from the Chesapeake Bay and
Intranuclear Virus-Like Inclusions in Mya arenaria with Germinomas from
a Maine Oil Spill Site. Haliotis (in press).
Otto, S.V. , Harshbarger, J.C., and Chang, S.C. Status of Selected Unicel¬
lular Eucaryote Pathogens, and Prevalence and Histopathology of Inclu¬
sions Containing Obligate Procaryote Parasites, in Commercial Bivalve
Mollusks from Maryland Estuaries. Haliotis (in press).
SELECTED OTHER ACTIVITIES IN 1977
1. Attended the Fish Health Workshop on 26 and 27 May 1977 at Easton,
Maryland.
2. Attended the Xth Annual Meeting of the Society for Invertebrate
Pathology on 22-26 August 1977 in East Lansing, Michigan.
3. Presented two papers: (1) "Status of Selected Unicellular Eucaryote
Pathogens, and Prevalence and Histopathology of Inclusions Contain¬
ing Obligate Procaryote Parasites, in Commercial Bivalve Mollusks
from Maryland Estuaries" (Otto, S.V. , Harshbarger, J.C., and Chang,
S.C.) and (2) "Proliferative Disorders in Crassostrea virginica
and Mya arenaria from the Chesapeake Bay and Intranuclear Virus-Like
Inclusions in Mya arenaria with Germinomas from a Maine Oil Spill
Site" (Harshbarger, J.C., Otto, S.V., and Chang, S.C.) at the Colloque
International de Pathologic et Parasitologic des Mollusques on 9-12
September 1977 in Perpignan, France.
4. Visited and consulted with personnel of the Fish Diseases Laboratory,
Weymouth, England, on 14 and 15 September 1977, regarding neoplasia
in fin fish and shellfish.
5. Presented the paper, "Feral Populations in Monitoring Environmental
Pollution. Part II - Aquatic," at the 105th Annual Meeting of the
American Public Health Association, on 30 October - 3 November 1977,
in Washington, D.C.
Participated in cooperative investigations of the ultrastructural
pathology of: (a) neoplasms in bivalves; (b) procaryotic organisms
in bivalves; and, (c) neoplasms in axolotls. {(a) and (b) were sup¬
ported in part by the U.S. Food and Drug Administration.}
6.
-6-
7. Attended Noon microscope slide pathology seminars at the U.S.
National Cancer Institute.
8. Attended lecture series on ultrastructural pathology at the U.S.
National Institutes of Health.
9. Served as a member of the planning committee for a forthcoming (2-4
October 1978) meeting on comparative pathology of zoo animals.
10. Served as a member of the Interagency Collaborative Group on Environ
mental Carcinogenesis (chaired by Herman F. Kraybill of the U.S.
National Cancer Institute).
11. Served as a member of the Committee on Animal Models and Genetic
Stocks of the Institute of Laboratory Animal Resources, National
Research Council, National Academy of Sciences.
12. Served as a member of the Permanent Program Committee of the Society
for Invertebrate Pathology.
13. Served as Vice President of the Washington, D.C. Chapter of Sigma Xi
The Scientific Research Society of North America.
PERSONNEL
The Project Officer for the contract is Dr. Clyde J. Dawe, Head,
Comparative Oncology Section, Laboratory of Pathology, National Cancer
Institute, National Institutes of Health, Bethesda, Maryland, 20014.
The Principal Investigator for the contract is Dr. W. Duane Hope,
Chairman, Department of Invertebrate Zoology, National Museum of Natural
History, Smithsonian Institution, Washington, D.C., 20560.
The Staff of the Registry is as follows:
John C. Harshbarger, Ph.D. - Director
Sing Chen Chang, Ph.D. - Electron Microscopist
Phyllis M. Schellenger, B.S. - Registrar
Linda J. Cullen, B.A. - Histopathology Technician
Judith E. Foster, B.S. - Research Assistant
Marilyn S. Slatick, B.S. - Bibliographer
-7-
ACCESSIONS
RTLA 1599. American oyster, Crassostrea virginica
Material ;
Habitat :
Diagnosis :
Three microscope slides
Apalachicola Bay, Florida
Hematopoietic neoplasm (gills heavily invaded); infec¬
ted with Dermocystidium marinum (particularly foci of
epithelium); a ciliate is present in the gills;
Nematopsis spores in the parenchymal tissue of body
and mantle
Submitter :
J. A. Couch
RTLA 1600. Indian rock python, Python molorus
Material :
Habitat :
Diagnosis :
Submibter :
Two microscope slides; 2 black and white prints
Collection of the San Diego Zoo, San Diego, California
Malignant lymphoma
P. T. Robinson
RTLA 1601. Two-color parrotfish, Bolbometopon blcolor
Material :
Habitat :
Diagnosis :
Submitter :
Gross specimen with a growth in the opercular cavity
Off Lapu Lapu City, Sabu, Philippines
Multiple protozoan cysts
G. C. Blasiola, Jr.
RTLA 1602. Spiny granite lizard, Sceloporus orcutti
Material :
Gross specimen with large, highly raised, firm, amor¬
phous lesion on right dorsal surface of neck; multiple,
similar, but smaller lesions on neck, dorsal surface
of right foreleg, and ventral surface of body
Habitat :
Diagnosis :
Pet; purchased from a dealer in California
Keratinizing epidermis in response to heavy fungus in¬
fection
Submitter :
S. B. Hedges
RTLA 1603. Sockeye salmon, Oncorhynchus nerka
Material :
Habitat :
Diagnosis :
Submitter :
Two microscope slides
Mariculture pens in Departure Bay, Nanaimo, B. C. , Canada
Teratoid anomaly
G. R. Bell
RTLA 1604. Dusky pigmy rattlesnake, Sistrurus milianus
Material :
Habitat :
Diagnosis :
Submitter:
Two microscope slides; 1 paraffin block
Jackson County, Florida
Mycotic granuloma due to a septate branching fungus
C. G. Crispens, Jr.
RTLA 1605. Weakfish, Cynoscion regalis
Material :
Habitat :
Diagnosis :
Submitter :
Four pieces of tissue; 2 microscope slides
York River, Virginia
Ganglioneuroma
D. E. Zwerner and C. L. Ruddell
-8-
RTLA 1606. Boa constrictor
Material :
Tissue: liver, pancreas, non-functlonlng testis and
ovary; 2 microscope slides
Diagnosis :
Hermaphrodite; sertoll cells prominent due to loss of
spermatogenesis
Submitter :
F. L. Frye
RTLA 1607. Sea star, Asterias forbesi
Material :
Three gross specimens: one with a small., firm, raised
growth on an arm; the other two injected with viruses
Diagnosis :
Specimen with growth: deformity of regeneration; two
specimens injected with viruses: no apparent reaction
Submitter :
F. B. Bang
RTLA 1608-1614.
Material :
Habitat :
Diagnosis :
Submitter :
Rock oyster, Crassostrea commercialis
Seven growths cut into cubes; 7 paraffin blocks
Greenwell Point, Shoalhaven River, Australia
Epidermal papillomas of the mantle
P. H. Wolf
RTLA 1615. Rainbow trout, Salmo galrdnerl
Material: One microscope slide; 1, 35 mm color transparency
Diagnosis: Nephroblastoma
Submitter: H. Wolf
RTLA 1616. Mexican axolotl, Amby stoma mexlcanum
Material: Two nodules
Diagnosis: Granulomas of probable helmlnthologlc etiology
Submitter: R. Verhoeff-de Fremery
RTLA 1617. Jewflsh, Eplnephelus Itajara
Material :
Two microscope slides; 6, 35 mm color transparencies;
4 electron photomicrographs
Diagnosis :
Submitter :
Mesotheliomas; rodlet cells
R. R. Shields
RTLA 1618. Kol carp, Cyprlnus carplo
Material :
Three small lesions surgically removed from the body
wall
Habitat :
Diagnosis :
Submitter :
Outdoor pond; Japanese Tea Gardens, San Jose, California
Neurilemraal sarcomas
G. C. Blasiola, Jr.
RTLA 1619. Red-spotted newt, Notophthalmus vlrldescens
Material :
Diagnosis :
Submitter :
Spleen with a large growth and several nodules
Infectious granulomas of acid-fast bacterial etiology
N. Cohen
RTLA 1620-1640.
Material :
Habitat :
Diagnosis :
Submitter :
Soft-shell clam, Mya arenaria
Twenty-one paraffin blocks; 1 pathology report
Various sites in the Chesapeake Bay
Cytoplasmic inclusions
S. V. Otto
-9-
RTLA 1641. Indigo snake, Dryroarchlon corals
Material: Two microscope slides
Habitat: Captive animal; Wolverhampton, England
Diagnosis: Multiple mycotic granulomas
Submitter: J. E. Cooper
RTLA 1642. Rainbow trout, Salmo gairdneri
Material: Two pieces of tissue from a lump
Habitat: Lake Eucumbene, New South Wales, Australia
Diagnosis: Neurilemmoma
Submitter: P. H. Wolf
RTLA 1643. Goldfish _
Material: Two gross specimens;
Carassius auratus
1 microscope slide; 3,
35 mm
color transparencies
Habitat: Backyard pond; Sacramento, California
Diagnosis: Neurilemmomas
Submitter: H. Wolf
RTLA
1644. Roach
Material :
Habitat :
Diagnosis :
Submitter :
, Rutilus rutilus
Two microscope slides
River in east of England
Early bile duct adenof Ibrosis, probably due to a
hepatotoxin
D. Bucke
RTLA
1645. Orgyi
Material :
Diagnosis :
Submitter :
£ pseudotsugata
Three pieces of a larva: 1 piece with a protrusion
between the first and second pair of prolegs
Teratosis or developmental anomaly, probably con~
genital or resulted from an injury in an early Instar
M. E. Martignoni and P. J. Iwai
RTLA 1646. Black fin pearlfish, Cynoleblas nigripinnls
Material: Gross specimen with a large growth involving the
left pectoral fin
Habitat : Tank raised
Diagnosis: Malignant lymphoma
Submitter: G. C. Blasiola, Jr.
RTLA 1647. Catfish, Corydoras sp.
Material: Gross specimen with black lesion on head
Habitat: Pet in a home aquarium
Diagnosis: Malignant melanophoroma
Submitter: J. Herrin
RTLA 1648. Trevally (jack), Caranx georgianus
Material: Two paraffin blocks
Habitat: Bay of Plenty, New Zealand
Diagnosis: Collagen reaction similar to acid injury to skin
Submitter: B. J. Stevenson
-10-
RTLA 1649. Trevally (jack), Caranx lutescens
Material: Two paraffin blocks
Habitat: Kaipara Harbour, New Zealand
Diagnosis: Melanocytic neurilemmoma (blue nevus)
Submitter: B. J. Stevenson
RTLA 1650. Rainbow trout, Salmo gairdneri
Material: Two paraffin blocks from soft fluctuant lesion on dorsum
Diagnosis: Cavernous hemangioma
Submitter: B. J. Stevenson
RTLA 1651. Brown trout, Salmo trutta
Material: Three microscope slides of white visceral growths
Habitat: Four miles from mouth of Grey River, New Zealand
Diagnosis: Leiomyoma
Submitter: B. J. Stevenson
RTLA 1652. Channel catfish, Ictalurus punctatus
Material: Two microscope slides of lesion in spleen
Diagnosis: Infectious granuloma
Submitter: A. L. Scott
RTLA 1653-1657.
Material :
Diagnosis :
Submitter :
Fathead minnow, Pimephales promelas
Gross specimen in 2 pieces: portion of head and re¬
mainder of animal (RTLA 1653); 2 gross specimens
(RTLA 1654 and 1655); 1 microscope slide and 1 paraffin
block (RTLA 1656); 9 microscope slides (RTLA 1657)
Induced lipoma
C. E. Smith
RTLA 1658. Fish
Material: A portion of body wall with eroded musculature
Diagnosis: Neural fibrosarcoma
Submitter: Unknown
RTLA 1659. Spot, Leiostomus xanthurus
Material: Gross specimen with 2 growths in abdominal region
Habitat: Bolivar Peninsula in Galveston Bay, Texas
Diagnosis: Microsporidan infection
Submitter: R. R. Stickney
RTLA 1660. Atlantic salmon, Salmo salar
Material: Three gross specimens; 2 microscope slides; 9 black
and white photographs; 18 color transparencies
Habitat: A sea loch on West coast of Scotland
Diagnosis: Leiomyosarcoma of the swim bladder
Submitter: I. McKnight and K. G. R. Elson
Reprint: McKnight, Ian J. Sarcoma of the Swim Bladder of Atlantic
Salmon (Salmo salar L.). Aquaculture, 13: 55-60. 1978.
Duncan, I. B. Evidence for an Oncovirus in Swimbladder
Fibrosarcoma of Atlantic Salmon Salmo salar L. J. Fish
Dis. , 1: 127-131. 1978.
-11-
RTLA 1661. Eel
Material ;
Diagnosis :
Submitters
Two gross specimens: 1 with multiple head lesions; 1
control
Bacterial granulomas; organism resembles Streptococcus sp
C. M, Bailey
RTLA 1662. Black drum, Pogonias cromis
Material; Two pound growth from visceral cavity
Habitat; Gulf of Mexico off Port Aransas, Texas
Diagnosis; Fibrolipoma
Submitter; A. G. Johnson
RTLA 1663. Brown shrimp, Penaeus aztecus
Material: Two gross shrimp; 6 microscope slides; manuscript
Habitat; Mississippi Sound, near Ocean Springs Small Boat Harbor
Diagnosis: Hamartoma; involved musculature within the sixth abdom¬
inal segment
Submitter; R. M. Overstreet
Reprint: Overstreet, Robin M. and Thomas Van Devender. Implica¬
tion of an Environmentally-Induced Hamartoma in Com¬
mercial Shrimps. J. Invertebr. Pathol., 31^; 234-238. 1978
RTLA 1664. Finescale menhaden, Bevoortia gunteri
Material; Gross specimen with growth on back between dorsal and
caudal f ins
Habitat; National Marine Fisheries Service dock. Port Aransas,
Texas
Diagnosis; Lipoma
Submitter; A. G. Johnson
RTLA 1665. South African clawed frog, Xenopus laevis
Material; Two microscope slides; enlarged spleen and spotted liver
Habitat: Laboratory
Diagnosis: Lymphosarcoma, multiple sites; hyperplastic, sclerotic
capsule surrounds spleen
Submitter: G. E. Cosgrove
RTLA 1666. South African clawed frog, Xenopus laevis
Material; One paraffin block
Habitat ; Laboratory
Diagnosis; Hyperplasia (?) — pancreatic islet
Submitter: G. E. Cosgrove
RTLA 1667. South African clawed frog, Xenopus laevis
Material ;
Habitat ;
Diagnosis ;
Submitter :
Two microscope slides
Laboratory
Granulomas near eye and near heart; strigeold metacer-
caria in blood clot; nematode (Caplllarla sp.) infec¬
tion in skin
G. E. Cosgrove
RTLA 1668, South African clawed frog, Xenopus laevis
-12-
RTLA 1668 (contd.
Material :
Habitat :
Diagnosis :
.)
One paraffin block from emaciated male
Laboratory
Bone marrow dysplasia associated with unidentified
particles in peripheral blood; nematode infection
in skin
Submitter :
G. E. Cosgrove
RTLA 1669. South African clawed frog, Xenopus laevis
Material :
Habitat :
Diagnosis :
Two microscope slides
Laboratory
Ovarian atrophy; nematode infection (Capillaria sp.)
in skin
Submitter :
G. E. Cosgrove
RTLA 1670. South African clawed frog, Xenopus laevis
Material :
Habitat :
Diagnosis :
Submitter :
Two microscope slides
Laboratory
Ovarian degeneration; severe congestion
G. E. Cosgrove
RTLA 1671. South African clawed frog, Xenopus laevis
Material :
Habitat :
Diagnosis :
Two microscope slides
Laboratory
Infected skin wound and body wall associated with mas¬
sive "monocytosis”; partial ovarian atrophy with mold
sclerosis; nematode infection (Capillaria sp.) in skin
Submitter :
G. E. Cosgrove
RTLA 1672. White cloud, Tanichthys albonubes
Material :
Habitat :
Diagnosis :
Three microscope slides
Aquarium
Subepidermal focus of cells — probably unicellular
parasites of some undeterminate type
Submitter :
G. E. Cosgrove
RTLA 1673. Red-spotted newt, Notophthalmus viridescens
Material: Eleven fragments from a dissected newt with enlarged
Habitat :
Diagnosis :
fluid filled abdomen
Near Caryville, Tennessee (Campbell County)
Severe cystic glomerular degeneration; intestinal
Submitter :
tapeworms
G. E. Cosgrove
RTLA 1674-1693.
Material :
Habitat :
Diagnosis :
Mexican axolotl, Ambystoma mexlcanum
Tissue; color transparencies
Laboratory
Adenoma (RTLA 1674) ; intradermal melanophoroma (RTLA
1691) ; mast cell tumors versus cutaneous nodules of
mastocytosis (RTLA 1675-1690, 1692, 1693)
Submitter :
L. E. DeLanney
RTLA 1694-1703.
Soft-shell clam, Mya arenaria
-13-
RTLA 1694-1703 (contd.)
Material: Eleven paraffin blocks from 3 specimens (RTLA 1694); 28
paraffin blocks from 12 specimens (RTLA 1695); 39 paraf¬
fin blocks from 12 specimens (RTLA 1696); 6 paraffin
blocks from 1 specimen (RTLA 1697) ; 4 paraffin blocks
from 2 specimens (RTLA 1698) ; 5 paraffin blocks from 3
specimens (RTLA 1699); 6 paraffin blocks from 3 speci¬
mens (RTLA 1700) ; 31 paraffin blocks from 12 specimens
(RTLA 1701); 20 paraffin blocks from 10 specimens (RTLA
1702); 20 paraffin blocks from 11 specimens (RTLA 1703);
map of collecting sites
Habitat: Ten collecting sites in Long Cove, Searsport, Maine,
representing various concentrations of petroleum from
spills
Diagnosis: Gonadal neoplasms (RTLA 1694-1697, 1699-1703); hemato¬
poietic neoplasm (RTLA 1698)
Submitter: P. P. Yevich
RTLA 1704. Brazilian snake, Spilotes pullatus
Material: Piece of liver tissue; 4 microscope slides; 2 paraffin
blocks
Diagnosis: Haemogregarine infection
Submitter: E. Elkan
RTLA 1705. Oscar, Astronotus ocellatus
Material: Two paraffin blocks
Diagnosis: Ichthyosporldium hoferi Infection
Submitter: E. Elkan
RTLA 1706. King
Material :
Diagnosis :
Submitter :
snake, Lampropeltis sp.
The remains of a multilocular cyst with clusters of
smaller type cysts attached to its outside surface
Pseudocystic calcinosis of probable bacterial etiology
(similar to tumoral calcinosis described by Slavin et
al. 1973. Brit. Med. J. , p. 147-149)
E. Elkan
RTLA 1707. Carp, Cyprinus carpio
Material :
Habitat :
Diagnosis :
Submitter :
Thirteen microscope slides; 3, 35 mm color transparen¬
cies; 7 black and white photographs; 5 diagrams; 3
color photomicrographs; 3 electron photomicrographs
Niigata Prefecture, Japan
Well-differentiated olfactory neuroepithelioma
Prince Masahito Hitachi
RTLA 1708. Gulf croaker, Micropogon megalops
Material: Two gross specimens: 1 pathologic (widely-scattered,
amorphous, flush black lesions on all body surfaces
and fins) — 1 control; specimen form and catalog
record form
Habitat: Golfo de California: passageway between Isla Montague
and coast of Baja California Norte, Mexico
-14-
RTLA 1708 (contd.)
Diagnosis; Probably an unusual type of host response to a para¬
site (trematode ?); nematodes were associated with
the viscera
Submitter: A. J. Mearns
RTLA 1709. Gulf
Material :
Habitat :
Diagnosis :
Submitter :
croaker, Micropogon megalops
Gross specimen with widely-scattered lesions on the
body and fins and with enlarged lips; specimen form
and catalog record form
Golfo de California: Puerto Penasco; Station Beach,
Mexico
Probably an unusual type of host response to a para¬
site (trematode ?)
A. J. Mearns
RTLA
1710. Brown
Material ;
Habitat :
Diagnosis :
Submitter :
shrimp , Penaeus aztecus
Six microscope slides
Reared at the University of Arizona-University of
Sonora shrimp culture research station at Puerto
Penasco, Sonora, Mexico
Papillary hyperplasia of the epidermis
D. V. Lightner
RTLA 1711. Rose
Material :
Diagnosis :
Submitter :
bitterling, Rhodeus ocellatus
Five microscope slides; 4 black and white photographs
Nephroblastoma
Prince Masahito Hitachi
RTLA 1712. Kinubari, Pterogoblus elapoides
Material: One microscope slide; 1 black and white photograph
Habitat: Enoshima Aquarium, Japan
Diagnosis: Adenoma
Submitter: Prince Masahito Hitachi
RTLA
1713. Coho
Material :
Habitat ;
Diagnosis :
Submitter :
salmon, Oncorhynchus klsutch
Six color transparencies; 1 electron photomicrograph
Pacific Ocean off Newport, Oregon
Response to a parasitic (microsporidan ?; haplospori-
dan ?) infestation of kidney tubules
R. Stroud
RTLA
1714. Lane
Material :
Habitat :
Diagnosis ;
Submitter :
snapper, Lutjanus synagris
Gross specimen with tail erosion
North Biscayne Bay, Miami, Florida
Ulceration and fibrosis
W. Kandrashoff
RTLA 1715. Sea catfish, Arlus fells
Material: Gross specimen with amorphous, flush skin lesions var¬
iously located on trunk
North Biscayne Bay, Miami, Florida
Habitat ;
-15-
RTLA 1715 (contd.)
Diagnosis: Loss of epidermis, bacterial infection and inflam¬
mation of dermis, subcutaneous fibrosis, atrophy of
underlying skeletal muscle with fibrous replacement
Submitter: W. Kandrashoff
RTLA 1716. Pinflsh, Lagodon rhomboides
Material: Gross specimen with scale disorientation
Habitat: North Blscayne Bay, Miami, Florida
Diagnosis: Slides not diagnostic
Submitter: W. Kandrashoff
RTLA 1717. Gray
Material :
Habitat :
Diagnosis :
Submitter :
(mangrove) snapper, Lut janus griseus
Gross specimen with curvature of distal portion of
lower spines of the caudal fin
North Blscayne Bay, Miami, Florida
Intermittent disappearance of supporting osseous sheath
concomitant with connective tissue swelling
W. Kandrashoff
RTLA
1718. Porgy
Material :
Habitat :
Diagnosis :
Submitter :
A piece of body wall with a round, gold, greasy lesion
North Blscayne Bay, Miami, Florida
Lipoma
W. Kandrashoff
RTLA 1719. Mojarra
Material: Caudal fin with central portion missing
Habitat: North Blscayne Bay, Miami, Florida
Diagnosis: Some type of worm parasite in peduncle
Submitter: W. Kandrashoff
RTLA 1720. Plnfish, Lagodon rhomboides
Material: Gross specimen with missing fin rays on the dorsal fin
and a missing left pelvic fin
Habitat: North Blscayne Bay, Miami, Florida
Diagnosis: Trematode-like worm parasite in muscle
Submitter: W. Kandrashoff
RTLA 1721. Pinfish, Lagodon rhomboides
Material: Gross specimen with scale disorientation
Diagnosis: Trematode-like worm parasite in dermis
Submitter: W. Kandrashoff
RTLA
1722. Porgy
Material :
Habitat :
Diagnosis :
Submitter :
Disoriented eye
North Blscayne Bay, Miami, Florida
Periorbital fibrosis associated with parasite
W. Kandrashoff
RTLA 1723. Guppy, Poecilla reticulata
Material: One microscope slide
-16-
RTLA 1723 (contd.)
Habitat: Aquarium
Diagnosis :
Liver undergone some fibrosis and contains granu¬
lomas; specimen experimentally treated with estrogen
Submitter :
S. Sherman
RTLA 1724. Weakfish, Cynoscion regalls
Material :
Two livers, one with abundant black pigment in the
Habitat :
Diagnosis :
mesentery
Off North Carolina coast
Infectious granulomas in both livers at least some of
which are due to nematode-like worm parasites. Multi¬
ple granulomas in mesentery of the one with excessive
black pigment
Submitter:
W. Kandrashoff
RTLA 1725. Mojarra
Material :
Habitat :
Diagnosis :
Submitter :
Disoriented eye
North Biscayne Bay, Miami, Florida
Nothing diagnostic in plane of section
W. Kandrashoff
RTLA 1726. Spotted sea trout, Cynoscion nebulosus
Material :
Disoriented eye; severely eroded tail; 1 color photo¬
graph
Habitat :
Diagnosis :
North Biscayne Bay, Miami, Florida
Caudal peduncle heavily infected with worm parasites
and protozoan parasites. Unicellular organisms in
periorbital region of eye
Submitter :
W. Kandrashoff
RTLA 1727. Margate, Haemulon album
Material: Deformed tail
Habitat :
Diagnosis :
Submitter:
North Biscayne Bay, Miami, Florida
Granulomas in caudal peduncle
W. Kandrashoff
RTLA 1728. Grunt, Haemulon sp
Material :
Habitat :
Diagnosis :
Submitter :
Fish head with twisted, misaligned lower jaw
Near Soldiers Key in South Biscayne Bay, Florida
Jaw contains worm granulomas
W. Kandrashoff
RTLA 1729. Pinfish, Lagodon r bomb o ides
Material :
A portion of body wall with scale disorientation and
dorsal fin with one missing ray and one mislocated ray
Habitat :
Diagnosis :
Submitter :
North Biscayne Bay, Miami, Florida
Worm parasite in dermis
W. Kandrashoff
RTLA 1730. Mojarra
Material: Posterior portion of fish with a firm, raised, oval
-17-
RTLA 1730 (contd.)
area on one side of the caudal peduncle
Habitat: North Biscayne Bay, Miami, Florida
Diagnosis: Lipoma
Submitter: W. Kandrashoff
RTLA
1731. Sea
Material :
Habitat :
Diagnosis :
Submitter :
bream (porgy) , Archosargus rhomboidalis
Growth: sliced into 4 pieces; drawing showing location
of growth on fish
Biscayne Bay, Miami, Florida
Exuberant fibrous response with associated inflammation
to a parasitic infection
E. P. Kraus
RTLA 1732. Platyfish swordtail backcross hybrid, Platypoecilus variatus
X Xlphophorus helleri x X* helleri
Material: Two black and white photographs; 1 schematic drawing of
lineage through hybridization
Habitat: Research Laboratory; Genet isches Instltut, Giessen,
Germany
Diagnosis: Rhabdomyosarcoma Induced by N-methyl-N-nitroso-urea
Submitter: M. Schwab
RTLA 1733. Platyfish swordtail backcross hybrid, Platypoecilus variatus
X Xlphophorus helleri x X. helleri
Material: Two black and white photographs; 1 schematic drawing
of lineage through hybridization
Habitat: Research Laboratory, Genetisches Instltut, Giessen,
Germany
Diagnosis : Fibrosarcoma induced by N-methyl-N-nltroso-urea
Submitter: M. Schwab
RTLA
1734. Greenling, Hexagrammos otakli
Material: Piece of tissue (filet) covered with minute, white,
dome-shaped lesions and minute, black flush lesions
Habitat: Kojima, Matsumae Town, Matsumae gun, Hokkaido, Japan
Diagnosis: Parasitic granulomas in response to a nematode
Submitter: K. Oishi
RTLA 1735 & 1736.
Material :
Habitat :
Diagnosis :
Submitter :
American oyster, Crassostrea virginica
One paraffin block each; 1 pathology report each
Chesapeake Bay; Chester River, Piney Point
Cytoplasmic Inclusions
S. V. Otto
RTLA 1737. Ribbed mussel, Brachidontes recurvus
Material: One paraffin block; pathology report
Habitat: Chesapeake Bay; Chester River, Piney Point
Diagnosis: Cytoplasmic inclusions
Submitter: S. V. Otto
RTLA 1738. Climbing perch, Anabas testudineus
-18-
RTLA 1738 (contd.)
Material: Six microscope slides; 2 photomicrographs
Diagnosis : Epidermal papilloma
Submitter; J. Pal
RTLA 1739. Siren lacertina
Material; One of two growths removed from the right side of
the animal
Diagnosis: Granulomas due to a bacterium
Submitter; K. Martin
RTLA 1740. Tiger salamander, Amby stoma tigrinum
Material: Two microscope slides; 1 paraffin block
Diagnosis: Transplanted melanophoroma
Submitter: F. L. Rose
RTLA 1741. Mussel, Mytilus californianus
Material: Two paraffin blocks
Habitat: Bodega, California
Diagnosis; Cytoplasmic inclusions in digestive diverticula and
in gut goblet cells
Submitter; P. P. Yevich and C. A. Barszcz
RTLA 1742. Mussel, Mytilus edulis
Material; Two paraffin blocks
Diagnosis: Cytoplasmic inclusions in both the plicate membrane
and the gills
Submitter: P. P. Yevich and C. A. Barszcz
RTLA 1743. Mussel, Mytilus edulis
Material: One microscope slide; 1 paraffin block
Diagnosis: Cytoplasmic inclusions in gills and plicate membrane;
trematode, Bucephalus , in connective tissue
Submitter: P. P. Yevich and C. A. Barszcz
RTLA 1744. Soft-shell clam, Mya arenaria
Material: One microscope slide
Diagnosis: Kidney hyperplasia associated with foci of necrotic
hemocytes
Submitter: P. P. Yevich and C. A. Barszcz
Reprint: Barry, M. M. , P. P. Yevich, and N. H. Thayer. Atypical
Hyperplasia in the Soft-Shell Clam Mya arenaria. J.
Invertebr. Pathol., 17: 17-27. 1971.
RTLA 1745. Soft-shell clam, Mya arenaria
Material: Two microscope slides
Diagnosis: Kidney hyperplasia associated with foci of necrotic
hemocytes
Submitter: P. P. Yevich and C. A. Barszcz
Reprint: (See RTLA 1744)
RTLA 1746. Mussel, Mytilus edulis
Material: One microscope slide
-19-
RTLA 1746 (contd.)
Diagnosis : Cytoplasmic inclusions in gills and inflammation
Submitter: P. P. Yevich and C. A. Barszcz
RTLA 1747. Carp,
Material :
Habitat :
Diagnosis :
Submitter :
Cyprinus carpio
Gross specimen with a large protruding growth on the
left dorsal side; 1 black and white photograph; 1,
35 mm color transparency
Watts Bar Reservoir, Tennessee
Neurilemmoma
D. Tomljanovich
RTLA 1748. American oyster, Crassostrea virginica
Material: Nine microscope slides; collecting data
Habitat: Chesapeake Bay; Punch Island, Tar Bay
Diagnosis: Germinoma
Submitter: S. V. Otto
RTLA 1749. American oyster, Crassostrea virginica
Material: Twelve microscope slides; collecting data
Habitat: Chesapeake Bay; Manokin River, Georges Bay
Diagnosis: Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA 1750. American oyster, Crassostrea virginica
Material: Eleven microscope slides
Diagnosis: Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA 1751. American oyster, Crassostrea virginica
Material: Nine microscope slides
Diagnosis: Cryptic adenomatous hyperplasia of mantle epithelium;
gill hyperplasia
Submitter: S. V. Otto
RTLA 1752. American oyster, Crassostrea virginica
Material: Ten microscope slides; collecting data
Habitat: Chesapeake Bay; Cedar Point Hollow
Diagnosis: Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA 1753. American oyster, Crassostrea virginica
Material: Eight microscope slides; collecting data
Habitat: Chesapeake Bay; Piney Island Swash Tray Area, Manokin
River, Broad Creek
Diagnosis: Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA 1754. American oyster, Crassostrea virginica
Material: Nine microscope slides; collecting data
Habitat: Chincoteague Bay, Franklin City, Chesapeake Bay, Manokin
Spat
Diagnosis: Hematopoietic neoplasm
-20-
RTLA 1754 (contd.)
Submitter: S. V.
Otto
RTLA 1755. American oyster, Crassostrea virginica
Material; Ten microscope slides; collecting data
Habitat; Chesapeake Bay; Big Annemessex River
Diagnosis: Cryptic adenomatous hyperplasia of mantle epithelium
Submitter: S. V. Otto
RTLA 1756. American oyster, Crassostrea virginica
Material: One microscope slide; collecting data
Habitat: Chesapeake Bay; Manokin River, Broad Creek Spat
Diagnosis: Cryptic adenomatous hyperplasia of mantle epithelium;
gill hyperplasia
Submitter: S. V. Otto
RTLA 1757. American oyster, Crassostrea virginica
Material: Ten microscope slides; collecting data
Habitat: Chesapeake Bay; Choptank River, Cook Point
Diagnosis: Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA 1758. American oyster
Material :
Diagnosis :
Submitter :
an oyster, Crassostrea virginica
One microscope slide; collecting data
Hematopoietic neoplasm
S. V. Otto
RTLA 1759. American oyster, Crassostrea virginica
Material; Ten microscope slides; collecting data
Habitat: Chesapeake Bay; Poplar Island
Diagnosis: Hematopoietic neoplasm
Submitter; S. V. Otto
RTLA 1760. American oyster, Crassostrea virginica
Material: One microscope slide; collecting data
Habitat: Chesapeake Bay; Broad Creek, Middleground
Diagnosis: Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA 1761. American oyster, Crassostrea virginica
Material: Five microscope slides; collecting data
Habitat: Manokin River
Diagnosis; Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA 1762. American oyster, Crassostrea virginica
Material: One microscope slide; collecting data
Habitat: Chesapeake Bay; Tangier Sound, Lambs tone
Diagnosis: Cryptic adenomatous hyperplasia of mantle epithelium
Submitter; S. V. Otto
RTLA 1763. American oyster, Crassostrea virginica
-21-
RTLA
1763 (contd.)
Material :
Habitat :
Diagnosis :
Submitter :
Nine microscope slides; collecting data
Chesapeake Bay; Old Field, Chester River
Undifferentiated sarcoma
S. V. Otto
RTLA 1764. American oyster, Crassostrea virginica
Material: Five microscope slides; collecting data
Habitat: Chesapeake Bay; Chester River, Plney Point
Diagnosis: Undifferentiated sarcoma
Submitter: S. V. Otto
RTLA 1765. American oyster, Crassostrea virginica
Material: One microscope slide; collecting data
Habitat: Chesapeake Bay; Broad Creek, Middleground
Diagnosis: Hematopoietic neoplasm
Submitter: S. V. Otto
RTLA
1766. Hard clam, Mercenaria mercenaria
Material: One microscope slide
Diagnosis: Nuclear inclusions in gonad
Submitter: S. V. Otto
RTLA
1767. Green
Material :
Habitat :
Diagnosis :
Submitter :
turtle, Chelonia mydas
Six pieces of tissue consisting of rugose growths at¬
tached to the skin of the lower jaw, right limb, and
surrounding both eyes; 4, 35 mm color transparencies
Kailua Beach, Island of Oahu, Hawaii
Fibropapillomas
G. H. Balazs
RTLA 1768. Mexican axolotl, Amby stoma mexicanum
Material: Three pieces of tissue: 1 piece of liver with part of
a growth and 2 pieces of skin and muscle with the re¬
maining portion of the growth
Diagnosis: Not diagnostic
Submitter: R. Verhoeff-de Fremery
RTLA 1769. South African clawed frog, Xenopus laevis
Material: Spherical growth with irregular surface crisscrossed by
blood vessels; 2 color transparencies
Diagnosis: Hematopoietic neoplasm — cell type undetermined
Submitter: R. Verhoeff-de Fremery
RTLA 1770. California king snake, Lampropeltis getulus
Material: Sixteen microscope slides; 10 electron photomicrographs
data sheet
Habitat: Hatched and raised at The American Museum of Natural
History, New York
Diagnosis: Lymphosarcoma
Submitter: E. Jacobson
-22-
RTLA 1771. Goldfish, Carassius auratus
Material :
Gross specimen with a flat, fungating, amorphous le¬
sion straddling the back
Habitat :
Diagnosis :
Submitter:
Pet
Neurilemmoma — poorly-differentiated
R. Marino
RTLA 1772. Gemfish (hake), Rexea solandri
Material :
Habitat :
Hard lesion from left side; 5 microscope slides
Between Sydney and Wollongong, New South Wales,
Australia
Diagnosis :
Scar tissue containing metaplastic bone — probably re¬
lated to an injury
Submitter :
P. H. Wolf
RTLA 1773. Atlantic salmon, Salmo salar
Material ;
Gross specimen with a firm, bean-shaped growth attached
to the belly, between the pectoral and pelvic fins.
The growth has a pectoral fin on the right, a less de¬
veloped pectoral fin on the left, and a pelvic fin.
Diagnosis :
Submitter :
Teratoid anomaly manifested by incomplete twinning
J. G. Hnath
RTLA 1774. Green turtle, Chelonia mydas
Material :
Total of eight growths: extending out of right posterior
lung; associated with right shoulder area; associated
with ventral area of esophagus and trachea; associated
with right lung; associated with lower intestine; 2
growths externally, one on each side of neck/head;
growth externally on right side of neck; 1 print of
live animal
Habitat :
Diagnosis :
Submitter :
Off of Waikiki Beach, Island of Oahu, Hawaii
Fibropapillomas
G. H. Balazs
RTLA 1775. Koi carp, Cyprinus carpio
Material :
Habitat :
Diagnosis :
Submitter :
Four microscope slides; autopsy report
Captive specimen
Nephroblastoma
G. C. Blasiola, Jr.
RTLA 1776. Porcupinef ish, Diodon hystrix
Material :
Gross specimen with a cluster of amorphous, cyst-like,
granular growths attached to the spines on the right
side of the animal
Habitat :
Diagnosis :
Submitter :
Naos Island Marine Lab, Balboa, Canal Zone (Pacific)
Lymphocystls
J. Cubit
RTLA 1777. Boa constrictor
Material :
Habitat :
Three gross juvenile specimens
Captive specimens
-23-
RTLA 1777 (contd.)
Diagnosis: Acute necrotizing enteritis
Submitter: I. Gorman
RTLA 1778. White sucker, Catostomus commersoni
Material: Two pieces of a lesion adhering to gut and liver
Habitat: Bozen Kill (part of Hudson River drainage. New York)
Diagnosis: Pancreatitis
Submitter: E. G. Hayunga
RTLA 1779. European flat oyster, Ostrea edulis
Material: Six microscope slides
Habitat: Ribadeo, Galicia, Spain; animals originally imported
from Italian Adriatic
Diagnosis: Hematopoietic neoplasm
Submitter: D. J. Alderman
Reprint: Alderman, D. J. , P. van Banning, and A. Perez-Colomer .
Two European Oyster (Ostrea edulis) Mortalities Asso¬
ciated with an Abnormal Haemocytic Condition. Aqua¬
culture, W: 335-340. 1977.
RTLA 1780. European flat oyster, Ostrea edulis
Material: Four microscope slides
Habitat: Carantec, Finisterre, France
Diagnosis: Aber disease; parasitized by the haplosporidan,
Marteilia refringens
Submitter: D. J. Alderman
Reprint: Alderman, David. Foreign Diseases Hazard British Shell¬
fish. New Scientist, pp. 122-124, 8 July 1974.
RTLA 1781. European flat oyster, Ostrea edulis
Material: One microscope slide
Habitat: Menai Straits, North Wales
Diagnosis: Systemic herpes virus infection
Submitter: D. J. Alderman
RTLA 1782. Lobster, Homarus vulgaris
Material: One microscope slide
Habitat: Maintained in experimental tanks at Ministry of Agri¬
culture, Fisheries and Food, Conway, North Wales
Diagnosis: Fungi (Ramularia sp.) in gut chitin
Submitter: D. J. Alderman
RTLA 1783. Coho salmon, Oncorhynchus kisutch
Material: One microscope slide
Diagnosis: Ependymoblastoma
Submitter: G. E. Hoskins
RTLA 1784. Congo tetra, Phenacogrammus interruptus
Material: Two microscope slides
Habitat: Metro Toronto Zoo, Toronto, Canada
Diagnosis: Well-differentiated epidermal carcinoma
-24-
RTLA 1784 (contd.)
Submitter: B. Hicks
RTLA 1785. Chinook salmon, Oncorhynchus tshawytscha
Material: Three microscope slides
Habitat: Rakaia River, New Zealand
Diagnosis: Undifferentiated spindle cell sarcoma; possibly an
embryonal rhabdomyoma
Submitter: B. J. Stevenson
RTLA 1786. Rainbow trout, Salmo gairdneri
Material: One microscope slide
Habitat: Coleridge, New Zealand
Diagnosis: Neurilemmoma
Submitter: B. J. Stevenson
RTLA 1787. Clam, Micromya (?)
Material : One clam
Habitat: Ten Mile Creek, Knox County, Tennessee
Diagnosis: Pending
Submitter: G. E. Cosgrove
RTLA 1788. Floater clam, Anodonta corpulenta
Material : Twenty-eight clams
Habitat: Melton Hill Lake, Anderson County, Tennessee
Diagnosis: Pending
Submitter: G. E. Cosgrove
RTLA 1789. Heel-splitter clam, Protoptera alata
Material: Eighteen clams
Habitat: Melton Hill Lake, Anderson County, Tennessee
Diagnosis: Pending
Submitter: G. E. Cosgrove
RTLA 1790. Floater clam (?), Anodonta corpulenta (?)
Material: Two clams
Habitat: White Oak Lake, Roane County, Tennessee
Diagnosis: Pending
Submitter: G. E. Cosgrove
RTLA 1791. Floater clam (?), Anodonta corpulenta (?)
Material: One clam
Habitat: White Oak Lake, Roane County, Tennessee
Diagnosis: Pending
Submitter: G. E. Cosgrove
RTLA 1792. Floater clam, Anodonta corpulenta
Material: Ten clams
Habitat: White Oak Lake, Roane County, Tennessee
Diagnosis: Pending
Submitter: G. E. Cosgrove
-25-
RTLA 1793. Heel-splitter clam, Protoptera alata
Material : Three clams
Habitat: Melton Hill Lake, Anderson County, Tennessee
Diagnosis: Pending
Submitter: G. E. Cosgrove
RTLA 1794. Rock oyster, Crassostrea commercialis
Material: Three microscope slides
Habitat: Myora Flat, Moreton Bay, Queensland, Australia
Diagnosis: Hematopoietic neoplasm; Tylocephalum sp. cysts pre¬
sent; Ancistrocoma sp. in wall of digestive diverticula
Submitter: P. H. Wolf
RTLA 1795. Rock oyster, Crassostrea commercialis
Material: Three microscope slides
Habitat: Greenwell Point near Nowra, New South Wales,
Diagnosis: Mantle papilloma
Submitter: P. H. Wolf
Australia
RTLA 1796. Pearl oyster, Pinctada maxima
Material: Three microscope slides
Habitat: Kuri Bay, North Western Australia (between Wyndham and
Derby) from a pearl farm
Diagnosis: Unidentified protistan parasite
Submitter: P. H. Wolf
Reprint: Wolf, Peter H. and Victor Sprague. An Unidentified Pro¬
tistan Parasite of the Pearl Oyster, Pinctada maxima,
in Tropical Australia. J. Invertebr. Pathol., 31^: 262-
263. 1978.
RTLA 1797. Rock oyster, Crassostrea commercialis
Material: Four microscope slides
Habitat: Terranora Creek, Tweed River, New South Wales, Australia
Diagnosis: Early infection of Marteilla sydneyi
Submitter: P. H. Wolf
RTLA 1798. Rock oyster, Crassostrea commercialis
Material: Six microscope slides
Habitat: Tweed River, New South Wales, Australia
Diagnosis: Heavy infection of Marteilla sydneyi
Submitter: P. H. Wolf
RTLA 1799. Blacklipped oyster, Crassostrea echinata
Material: Six microscope slides; 1 reprint
Habitat: Mangrove roots in Middle Arm, Darwin, Northern Territory,
Australia
Diagnosis: Unidentified protistan parasite; also Tylocephalum sp.
cysts
Submitter: P. H. Wolf
Reprint: Wolf, Peter H. An Unidentified Protistan Parasite in the
Ova of the Blacklipped Oyster, Crassostrea echinata ,
from Northern Australia. J. Invertebr. Pathol., 244-
246. 1977.
-26-
RTLA 1800. Threesplne stickleback, Gasterosteus aculeatus
Material: Twelve microscope slides
Habitat :
Ventura River System, Ventura County, California —
in the lower few miles of the river
Diagnosis :
Submitter :
Pseudocystic microsporidan granuloma
M. A. Bell
RTLA 1801. Threespine stickleback, Gasterosteus aculeatus
Material: Gross specimen with a pea-shaped growth on right ven-
Habitat :
tro-lateral aspect
Ventura River System, Ventura County, California —
lower few miles of the river
Diagnosis :
Submitter :
Pseudocystic microsporidan granuloma
M. A. Bell
RTLA 1802. Threesplne stickleback, Gasterosteus aculeatus
Material: Gross specimen with pea-shaped growth on right dorso-
Habitat :
lateral aspect
Ventura River System, Ventura County, California —
lower few miles of the river
Diagnosis :
Submitter :
Pseudocystic microsporidan granuloma
M. A. Bell
RTLA 1803. Threespine stickleback, Gasterosteus aculeatus
Material: Gross specimen with pea-shaped growth on left mld-
Habitat :
lateral aspect
Ventura River System, Ventura County, California,
Ojai in San Antonio Creek
Diagnosis :
Submitter:
Pseudocystic microsporidan granuloma
M. A. Bell
RTLA 1804. Threesplne stickleback, Gasterosteus aculeatus
Material: Gross specimen with pea-shaped growth on right ventro-
Habitat :
lateral aspect
Ventura River System, Ventura County, California —
lower few miles of the river
Diagnosis :
Submitter :
Pseudocystic microsporidan granuloma
M. A. Bell
RTLA 1805. Threespine stickleback, Gasterosteus aculeatus
Material: One x-ray positive of "normal" gross specimens and
Habitat :
Diagnosis :
gross specimens with foreshortened vertebral columns
Ventura River System, Ventura County, California
Skeletal anomalies possibly associated with chemical
pollution
Submitter :
M. A. Bell
RTLA 1806. Emerald shiner, Notropls atherlnoides ; Sand shiner, Notropis
stramineus ; Bluntnose minnow, Pimephales notatus ; Mimic
shiner, Notropis volucellus
Material :
Two hundred five gross specimens from the above genera
and species
-27-
RTLA 1806 (contd.)
Habitat: Ohio River: Pike Island Lock and Dam
Diagnosis: Cubic nuclear inclusions in ganglion cells
Submitter: ORSANCO Survey
RTLA 1807. European flat oyster, Ostrea edulis
Material: One paraffin block; reprint
Habitat: Mali-Ston area of Yugoslavia near Dubrovnic
Diagnosis: Hematopoietic neoplasm
Submitter: P. van Banning
Reprint: (See RTLA 1779)
RTLA 1808. European flat oyster, Ostrea edulis
Material: One paraffin block
Habitat: Paimpol, France
Diagnosis: Hematopoietic neoplasm
Submitter: P. van Banning
RTLA 1809. European flat oyster, Ostrea edulis
Material: One paraffin block
Habitat: Paimpol, France
Diagnosis: Hematopoietic neoplasm
Submitter: P. van Banning
RTLA 1810.1 - 1810.5. Thin tellin, Tellina tenuis
Material :
Habitat :
Diagnosis :
Submitter :
Reprint :
Five microscope slides; 10, 35 mm color transparencies
Aultbea, Loch Ewe, Wester Ross, Scotland
RTLA 1810.1 - Procaryote-like inclusions in digestive
diverticulum; RTLA 1810.2 - procaryote-like inclusions
in gut epithelium and digestive diverticulum; RTLA
1810.3 - normal male and female; coccidan in ovary;
RTLA 1810.4 & 1810.5 - pending
J. S. Buchanan
Buchanan, J. S. On the Presence of a New Species of
Rickettsia Found Together with an Associated Phage
in the Digestive Gland of the Marine Pelecypod Mol¬
lusc, Tellina tenuis (da Costa). Haliotis. (in press).
RTLA 1811. Coho salmon, Oncorhynchus kisutch
Material: Four microscope slides
Habitat: Reared in fiberglass tanks; water source was river water
which was chlorinated-dechlorinated
Diagnosis: Ependymoblastoma
Submitter: J. D. Hendricks
RTLA 1812. Tiger snake, Notechis ater
Material: One microscope slide
Diagnosis: Pancreatic trematodiasis
Submitter: B. L. Munday
RTLA 1813. Metallic skink, Leiolopisma metallicum
Material: One microscope slide
RTLA 1813 (contd.)
Diagnosis: Sarcosporidiosis
Submitter: B. L. Munday
-28-
RTLA 181A. Rainbow trout, Salmo gairdneri
Material: Sixteen microscope slides; 3 color transparencies
Diagnosis: Malignant lymphoma, diffuse, poorly-differentiated type
Submitter: C. E. Smith
RTLA
1815. Heteropneustes fossilis
Material: Two microscope slides; 4
and white photograph
Diagnosis: Lipoma
Submitter: J. Pal
pieces of a growth; 1 black
RTLA
1816. Hawksblll turtle, Eretmochelys
Material: Tissue: section of small
ach — growth associated
Habitat: Held in captivity at the
Hawaii
Diagnosis: Granuloma
Submitter: G. H. Balazs
imbricate
intestine adjacent to stom-
with metal fragment
Waikiki Aquarium, Waikiki,
RTLA 1817. Boa constrictor
Material: Gross specimen
Habitat: Captive bred; Los Angeles, California
Diagnosis: Acute necrotizing enteritis
Submitter: I. Gorman
RTLA 1818. Oyster
Material: Twenty microscope slides
Habitat: Laboratory; Narragansett , Rhode Island
Diagnosis: Arsenic induced hematopoiesis
Submitter: P. P. Yevich
RTLA 1819. Timber rattlesnake, Crotalus horridus horridus
Material: One microscope slide; necrospy report
Habitat: Wethersfield Nature Center, Connecticut
Diagnosis: Angiosarcoma
Submitter: E. Jacobson and S. W. Nielsen
RTLA 1820. Corn
Material :
Diagnosis :
Submitter :
snake , Elaphe guttata guttata
Four microscope slides; necropsy report
Extramedullary hematopoiesis versus low grade granulo¬
cytic leukemia
E. Jacobson and R. E. Brannian
RTLA 1821. Green lizard, Lacerta viridis
Material: One paraffin block; 1 photomicrograph
Diagnosis: Epidermal papilloma containing intranuclear virus-like
Inclusions
Submitter: E. Elkan
-29-
RTLA 1822. Goldfish, Carassius auratus
Material :
Growth removed from the right side of the head, near
eye
Habitat :
Aquarium pet; Texas
Diagnosis :
Ichthyematoma (fish scale tumor)
Submitter :
N. Herwig
RTLA 1823. Boa
constrictor
Material :
One microscope slide
Diagnosis :
Lipoma
Submitter ;
F. L. Frye
RTLA 1824. Lampfish (?), Lampanyctus cuprarlus
Material :
Gross specimen with a growth on the right caudal
peduncle
Habitat :
South of Bermuda
Diagnosis :
Lesion contains multlnucleate lavender cells thought
to be parasites
Submitter :
B. J. Zahuranec
RTLA 1825-1830.
Rock oyster, Crassostrea commerclalis
Material :
Fixed tumor tissue for electron microscopy
Habitat :
Nowra (Greenwell Point), New South Wales, Australia
Diagnosis :
Papilloma of mantle epithelium
Submitter :
P. H. Wolf
RTLA 1831 & 1832
. European flat oyster, Ostrea edulis
Material :
Six microscope slides
Habitat :
Carantec, Brittany, France
Diagnosis :
Aber disease (Marteilia refringens)
Submitter :
D. J. Alderman
RTLA 1833. Mussel, Mytilus edulis
Material :
Seven microscope slides
Habitat :
Menai Straits, North Wales
Diagnosis :
Hematopoietic neoplasm
Submitter :
D. J. Alderman
RTLA 1834. Scallop
Material :
Two microscope slides
Diagnosis :
Hematopoietic neoplasm versus reactive hematopoiesis
Submitter :
R. S. Brown
RTLA 1835. California king snake, Lampropeltls getulus
Material :
Two microscope slides; 4 photomicrographs; reprint
Habitat :
Walnut Creek, California
Diagnosis :
Squamous (versus mucoepidermoid) carcinoma of probable
salivary gland origin
Submitter :
J. R. Hill
Reprint :
Hill, James R. Oral Squamous Cell Carcinoma in a Call-
fornia King Snake. J. Amer. Vet. Med. Assoc., 171 :
982. 1977.
-30-
RTLA 1836. Nurse
Material :
Habitat :
Diagnosis :
Submitter:
shark, Ginglymostoma cirratum
Three microscope slides; 3 paraffin blocks; pathology
report
Florida Keys
Adenoma or follicular hyperplasia, possibly of thyroid
origin
S. Gruber, W. Riemer, and M. M. Sigel
RTLA 1837. Lahonton cutthroat trout, Salmo dark!
Material: Tissue block; 5 microscope slides
Habitat: Pyramid Lake, Nevada
Diagnosis: Carcinoma, probably of ultimobranchial gland origin
Submitter: C. E. Smith
-31-
INDEX OF NEOPLASM - ANIMAL GROUP - AND RTLA NUMBER
Adenoma: Amphibian - RTLA 1674; Bony fish - RTLA 1712; Cartilaginous
fish - RTLA 1836
Angiosarcoma; Reptile - RTLA 1819
Carcinoma: Bony fish - RTLA 1837
Cavernous hemangioma: Bony fish - RTLA 1650
Ependymoblastoma: Bony fish - RTLA 1783, 1811
Epidermal carcinoma; Bony fish - RTLA 1784
Epidermal papilloma: Reptile - RTLA 1821; Bony fish - RTLA 1738; Mollusk
RTLA 1608-1614, 1795, 1825-1830
Extramedullary hematopoiesis versus low grade granulocytic leukemia:
Reptile - RTLA 1820
Flbrolipoma: Bony fish - RTLA 1662
Fibropapilloma : Reptile - RTLA 1767, 1774
Fibrosarcoma: Bony fish - RTLA 1733
Ganglioneuroma: Bony fish - RTLA 1605
Germinoma: Mollusk - RTLA 1694-1697, 1699-1703, 1748
Hamartoma: Crustacean - RTLA 1663
Hematopoietic neoplasm: Reptile - RTLA 1600, 1770; Amphibian - RTLA 1665,
1769; Bony fish - RTLA 1646, 1814; Mollusk - RTLA 1599, 1698, 1749,
1750, 1752-1754, 1757-1761, 1765, 1779, 1794, 1807-1809, 1833
Hematopoietic neoplasm versus reactive hematopoiesis: Mollusk - RTLA 1834
Ichthyematoma (fish scale tumor): Bony fish - RTLA 1822
Leiomyoma: Bony fish - RTLA 1651 ^
Leiomyosarcoma: Bony fish - RTLA 1660
Lipoma: Reptile - RTLA 1823; Bony fish - RTLA 1653-1657, 1664, 1718, 1730
1815
Malignant melanophoroma : Bony fish - RTLA 1647
Mast cell tumors versus cutaneous nodules of mastocytosis: Amphibian -
RTLA 1675-1690, 1692, 1693
-32-
Melanocytic neurilemmoma (blue nevus): Bony fish - RTLA 1649
Melanophoroma: Amphibian - RTLA 1691, 1740
Mesothelioma; Bony fish - RTLA 1617
Nephroblastoma; Bony fish - RTLA 1615, 1711, 1775
Neural fibrosarcoma; Bony fish - RTLA 1658
Neurllemmal sarcoma; Bony fish - RTLA 1618
Neurilemmoma; Bony fish - RTLA 1642, 1643, 1747, 1771, 1786
Olfactory neuroepithelioma; Bony fish - RTLA 1707
Rhabdomyosarcoma; Bony fish - RTLA 1732
Sarcoma (undifferentiated); Bony fish - RTLA 1785; Mollusk - RTLA 1763,
1764
Squamous (versus mucoepidermoid) carcinoma; Reptile - RTLA 1835
-33-
PHYLOGENETIC INDEX
PHYLUM CHORDATA
Class Reptilia
Order Chelonia (turtles) - RTLA 1767, 1774, 1816
Order Squamata (lizards, snakes, skinks) - RTLA 1600, 1602, 1604,
1606, 1641, 1704, 1706, 1770, 1777, 1812, 1813, 1817, 1819-1821,
1823, 1835
Class Amphibia
Order Anura (toads, frogs) - RTLA 1665-1671, 1769
Order Caudata (axolotls, salamanders, newts) - RTLA 1616, 1619,
1673-1693, 1739, 1740, 1768
Class Osteiohthyes
Order Myctophif ormes (lanternf ishes) - RTLA 1824
Order Labyrinthici (labyrinth fishes) - RTLA 1738
Order Anguilliformes (eels) - RTLA 1661
Order Clupeiformes (herrings, anchovies) - RTLA 1664
Order Gasterosteiformes (sticklebacks) - RTLA 1800-1805
Order Salmoniformes
Family Salmonidae (salmon, trout, whitefish, cisco) - RTLA 1603,
1615, 1642, 1650, 1651, 1660, 1713, 1773, 1783, 1785, 1786,
1811, 1814, 1837
Order Cypriniformes (suckers, goldfish, carp, minnows, roaches,
scissorstail) - RTLA 1618, 1643, 1644, 1653-1657, 1672, 1707,
1711, 1747, 1771, 1775, 1778, 1784, 1806, 1822
Order Siluriformes (catfish, bullheads) - RTLA 1647, 1652, 1715,
1815
Order Atheriniformes (killifish, platys, needlefish, guppies,
mollies, top minnows) - RTLA 1646, 1723, 1732, 1733
Order Perci formes
Family Scaridae (parrotf ishes) - RTLA 1601
-34-
Famlly Pomadasyidae (grunts) - RTLA 1727, 1728
Family Hexagrammldae (greenlings) - RTLA 1734
Family Serranidae (sea basses) - RTLA 1617
Family Gobiidae (gobies) - RTLA 1712
Family Gerreidae (mojarras) - RTLA 1719, 1725, 1730
Family Carangidae (jacks, pompanos) - RTLA 1648, 1649
Family Lutjanidae (snappers) - RTLA 1714, 1717
Family Sparldae (porgies, pinfish) - RTLA 1716, 1718, 1720-
1722, 1729, 1731
Family Sciaenldae (drums, croakers) - RTLA 1605, 1659, 1662,
1708, 1709, 1724, 1726
Family Cichlidae (cichlids) - RTLA 1705
Family Acinaceidae (gemfish) - RTLA 1772
Order Tetraodontiformes (porcupinef ishes) - RTLA 1776
Not classified - RTLA 1658
Class Chondriahthyes
Order Squaliformes (sharks) - RTLA 1836
PHYLUM ECHINODERMATA
Class Astevoidea (sea stars) - RTLA 1607
PHYLUM ARTHROPODA
Class Inseata - RTLA 1645
Class Crustaeea
Order Decapoda (shrimp, lobster) - RTLA 1663, 1710, 1782
PHYLUM MOLLUSCA
Class Bivalvia (mussels, clams, scallops, oysters) - RTLA 1599, 1608-
1614, 1620-1640, 1694-1703, 1735-1737, 1741-1746, 1748-1766, 1779-
1781, 1787-1799, 1807-1810, 1818, 1825-1834
-35-
INDEX OF SPECIMENS BY SCIENTIFIC AND COMMON NAMES
RTLA Number
Ambystoma mexicanum
1616, 1674-1693,
Ambystoma tigrinum
1740
American oyster
1599, 1735, 1736
Anabas testudineus
1738
Anodonta corpulenta
1788, 1790-1792
Archosargus rhomboidalis
1731
Arius felis
1715
Asterias forbesi
1607
Astronotus ocellatus
1705
Atlantic salmon
B
Bevoortia gunteri
1660, 1773
1664
Black drum
1662
Black fin pearlfish
1646
Blacklipped oyster
1799
Bluntnose minnow
1806
Boa constrictor
1606, 1777, 1817;
Bolbometopon bicolor
1601
Brachidontes recurvus
1737
Brazilian snake
1704
Brown shrimp
1663, 1710
Brown trout
n
1651
L
California king snake
1770, 1835
Caranx georgianus
1648
Caranx lutescens
1649
Carassius auratus
1643, 1771, 1822
Carp
1707, 1747
Catfish
1647
Catos tomus commersoni
1778
Channel catfish
1652
Chelonia mydas
1767, 1774
Chinook salmon
1785
Clam
1787
Climbing perch
1738
Coho salmon
1713, 1783, 1811
Congo tetra
1784
Corn snake
1820
Corydoras sp.
1647
Crassostrea commercialis
1608-1614, 1794,
1798, 1825-183(
Crassostrea echinata
1799
-36-
RTLA Number
Crassostrea virginica
Crotalus horridus horridus
Cynoleb ias nigripinnis
Cynoscion nebulosus
Cynosclon regalis
Cyprinus carpio
1599, 1735, 1736, 1748-1765
1819
1646
1726
1605, 1724
1618, 1707, 1747, 1775
Diodon hystrix
1776
Drymarchion corals
1641
Dusky pigmy rattlesnake
1604
E
Eel
1661
Elaphe guttata guttata
1820
Emerald shiner
1806
Epinephelus italara
1617
Eretmochelys imbricata
1816
European flat oyster
1779-1781,
1832
F
Fathead minnow
1653-1657
Finescale menhaden
1664
Fish
1658
Floater clam
1788, 1790
G
Gasterosteus aculeatus
1800-1805
Gemf ish
1772
Ginglymostoma cirratum
1836
Goldfish
1643, 1771
Gray snapper
1717
Green lizard
1821
Green turtle
1767, 1774
Greenling
1734
Grunt
1728
Gulf croaker
1708, 1709
Guppy
1723
H
Haemulon sp.
1728
Ha emu Ion album
1727
Hard clam
1766
Hawksbill turtle
1816
-37-
RTLA Number
Heel-splitter clam
1789, 1793
Heteropneustes fossilis
1815
Hexagrammos otakii
1734
Homarus vulgaris
1
Ictalurus punctatus
1782
1652
Indian rock python
1600
Indigo snake
1641
J
Jewf ish
1617
K
King snake
1706
Kinubari
1712
Koi carp
1618, 1775
L
Lacerta viridis
1821
Lagodon rhomboides
1716, 1720, 1721
Lahonton cutthroat trout
1837
Lampanyctus cuprarius
1824
Lamp fish
1824
Lampropeltis sp.
1706
Lampropeltis getulus
1770, 1835
Lane snapper
1714
Leiolopisma metallicum
1813
Leiostomus xanthurus
1659
Lobster
1782
Lutianus griseus
1717
Lutianus synagris
1714
M
Margate
1727
Mercenaria mercenaria
1766
Metallic skink
1813
Mexican axolotl
1616, 1674-1693,
Micromya
1787
Micropogon mega lops
1708, 1709
Mimic shiner
1806
Mojarra
1719, 1725, 1730
Mussel
1741-1743, 1746,
Mya arenaria
1620-1640, 1694-;
1745
-38-
RTLA Number
Mytilus californlanus
Mytilus edulis
N
Notechis ater
1741
1742,
1743
1812
Notophthalmus virldescens
1619,
1673
Notropis atherinoides
1806
Notropis stramineus
1806
Notropis volucellus
Nurse shark
1806
1836
0
Oncorhynchus kisutch
1713, 1783
Oncorhynchus nerka
1603
Oncorhynchus tshawytscha
1785
Orgyia pseudotsugata
1645
Oscar
1705
Ostrea edulis
1779-1781,
1832
Oyster
P
1818
Pearl oyster
1796
Penaeus aztecus
1663, 1710
Phenacogranmus interruptus
1784
Pimephales notatus
1806
Pimephales promelas
1653-1657
Pinctada maxima
1796
Pinfish
1716, 1720
Platyfish swordtail backcross hybrid
Platypoecilus variatus x Xiphophorus
1732, 1733
helleri x X. hellerl
1732, 1733
Poecilia reticulata
1723
Pogonias cromis
1662
Porcupinef ish
1776
Porgy
1718, 1722
Protoptera alata
1789, 1793
Pterogobius elapoides
1712
Python molorus
R
1600
Rainbow trout
1615, 1642
Red-spotted newt
1619, 1673
Rexea solandri
1772
Rhodeus ocellatus
1711
Ribbed mussel
1737
Roach
1644
17A6, 1833
1811
1807-1809,
1721, 1729
1650, 1786
1831,
, 1814
-39-
RTLA Number
Rock oyster
Rose bitterling
Rutilus rutilus
S
Salmo dark!
Salmo gairdneri
Salmo salar
Salmo trutta
Sand shiner
Scallop
Sceloporus orcutti
Sea bream
Sea catfish
Sea star
Siren lacertina
Sistrurus milianus
Sockeye salmon
Soft-shell clam
South African clawed frog
Spilotes pullatus
Spiny granite lizard
Spot
Spotted sea trout
I
Tanichthys albonubes
Tellina tenuis
Thin tell in
Threespine stickleback
Tiger salamander
Tiger snake
Timber rattlesnake
Trevally
Two-color parrotfish
W
Weakf ish
White cloud
White sucker
XYZ
Xenopus laevis
1608-1614, 1794, 1795, 1797,
1798, 1825-1830
1711
1644
1837
1615, 1642, 1650, 1786, 1814
1660, 1773
1651
1806
1834
1602
1731
1715
1607
1739
1604
1603
1620-1640, 1694-1703, 1744,
1745
1665-1671, 1769
1704
1602
1659
1726
1672
1810
1810
1800-1805
1740
1812
1819
1648, 1649
1601
1605, 1724
1672
1778
1665-1671, 1769
-40-
CONTRIBUTORS
ALDERMAN, D. J.
Fish Diseases Laboratory
Ministry of Agriculture,
Fisheries and Food
The Nothe, We5rmouth
Dorset DT4 SUB, England
RTLA 1779-1782, 1831-1833
BAILEY, C. M.
Sea-Arama Marineworld
Seawall Boulevard at 91st Street
P. 0, Box 3068
Galveston, Texas 77550
RTLA 1661
BALAZS, G. H.
Hawaii Institute of
Marine Biology
University of Hawaii at Manoa
P. 0. Box 1346
Coconut Island
Kaneohe, Hawaii 96744
RTLA 1767, 1774, 1816
BANG, F. B.
Department of Pathobiology
The Johns Hopkins University
615 North Wolfe Street
Baltimore, Maryland 21205
RTLA 1607
BARSZCZ, C. A.
Environmental Research Laboratory
U.S. Environmental Protection
Agency
South Ferry Road
Narragansett , Rhode Island 02882
RTLA 1741-1746
BELL, G. R.
Pacific Biological Station
P. 0. Box 100
Nanaimo, B. C. , V9R 5K6, Canada
RTLA 1603
BELL, M. A.
Department of Biology
University of California
Los Angeles, California 90024
RTLA 1800-1805
BLASIOLA, G. C., JR.
Stelnhart Aquarium
California Academy of Sciences
Golden Gate Park
San Francisco, California 94118
RTLA 1601, 1618, 1646, 1775
BRANNIAN, R. E.
4529 West 36-1/2 Street
St. Louis Park, Minnesota 55416
RTLA 1820
BROWN, R. S.
Animal Pathology Department
University of Rhode Island
Kingston, Rhode Island 02881
RTLA 1834
BUCHANAN, J. S.
Unit of Aquatic Pathobiology
University of Stirling
Stirling FK9 4LA, Scotland
RTLA 1810
BUCKE, D.
Fish Diseases Laboratory
Ministry of Agriculture,
Fisheries and Food
The Nothe, Weymouth
Dorset DT4 8UB, England
RTLA 1644
COHEN, N.
Department of Microbiology
The University of Rochester
Rochester, New York 14642
RTLA 1619
COOPER, J. E.
Clinical Research Centre
Watford Road
Harrow, Middlesex HAl 3UJ
England
RTLA 1641
COSGROVE, G. E.
Zoological Society of San Diego
Box 551
San Diego, California 92112
RTLA 1665-1673, 1787-1793
-41-
COUCH, J. A.
Environmental Research Laboratory
U.S. Environmental Protection
Agency
Sabine Island
Gulf Breeze, Florida 32561
RTLA 1599
CRISPENS, C. G., JR.
Department of Biology
The University of Alabama
in Birmingham
University Station
Birmingham, Alabama 35294
RTLA 1604
CUBIT, J.
Smithsonian Tropical Research
Institute, P. 0. Box 2072
Balboa, Canal Zone
RTLA 1776
DELANNEY, L. E.
4712 Northeast 60th Street
Seattle, Washington 98105
RTLA 1674-1693
ELKAN, E.
Department of Histopathology
Mt. Vernon Hospital
Northwood, Middlesex HA6 2RN
England
RTLA 1704-1706, 1821
ELSON, K. G. R.
Department of Agriculture and
Fisheries for Scotland
Marine Laboratory, P. 0. Box 101
Torry, Aberdeen AB9 8DB, Scotland
RTLA 1660
FRYE, F. L.
School of Veterinary Medicine
University of California
Davis, California 95616
RTLA 1606, 1823
GORMAN, I.
Sharkey - Simpson
1500-1502 W. Santa Barbara Avenue
Los Angeles, California 90062
RTLA 1777, 1817
GRUBER, S.
Department of Microbiology
School of Medicine
University of Miami
P. 0. Box 520875
Biscayne Annex
Miami, Florida 33152
RTLA 1836
HAYUNGA, E. G.
Immunoparasitology
Naval Medical Research Institute
National Naval Medical Center
Building 142
Bethesda, Maryland 20014
RTLA 1778
HEDGES, S. B.
Division of Reptiles and Amphibians
National Museum of Natural History
Room W-203
Smithsonian Institution
Washington, D. C. 20560
RTLA 1602
HENDRICKS, J. D.
Department of Food Science and
Technology
Oregon State University
Corvallis, Oregon 97331
RTLA 1811
HERRIN, J.
Apartment //I
2026 Columbia Pike
Arlington, Virginia 22204
RTLA 1647
HERWIG, N.
San Antonio Zoological Gardens
and Aquarium
3903 North St. Mary's Street
San Antonio, Texas 78212
RTLA 1822
HICKS, B.
Department of Pathology
Ontario Veterinary College
University of Guelph
Guelph, Ontario NIG 2W1 , Canada
RTLA 1784
-42-
HILL, J. R.
Department of Pathology
Syntax Research
Palo Alto, California 94304
RTLA 1835
HITACHI, PRINCE MASAHITO
Cancer Institute
Kami-Ikebukuro , Toshima-ku
Tokyo 170, Japan
RTLA 1707, 1711, 1712
HNATH, J. G.
Wolf Lake Fish Hatchery
Michigan Department of
Natural Resources
Route //I
Mattawan, Michigan 49071
RTLA 1773
HOSKINS, G. E.
Pacific Biological Station
P. 0. Box 100
Nanaimo, B. C. V9R 5K6, Canada
RTLA 1783
IWAI, P. J.
Forestry Sciences Laboratory
U.S. Department of Agriculture
3200 Jefferson Way
Corvallis, Oregon 97331
RTLA 1645
JACOBSON, E.
Division of Comparative Medicine
Health Center Animal Resources
Department
J. Hillis Miller Health Center
University of Florida
P. 0. Box J-6
Gainesville, Florida 32610
RTLA 1770, 1819, 1820
JOHNSON, A. G.
Port Aransas Laboratory
Southeast Fisheries Center
Port Aransas, Texas 78373
RTLA 1662, 1664
KANDRASHOFF, W.
951 Euclid Avenue
Miami Beach, Florida 33139
RTLA 1714-1722, 1724-1730
KRAUS, E. P.
Department of Microbiology
School of Medicine
University of Miami
P. 0. Box 520875, Blscayne Annex
Miami, Florida 33152
RTLA 1731
LIGHTNER, D. V.
Environmental Research Laboratory
The University of Arizona
Tucson International Airport
Tucson, Arizona 85706
RTLA 1710
MCKNIGHT, I.
Department of Agriculture and
Fisheries for Scotland
Marine Laboratory, P. 0. Box 101
Torry, Aberdeen AB9 8DB, Scotland
RTLA 1660
MARINO, R.
1924 Northwest 21st
Oklahoma City, Oklahoma 73106
RTLA 1771
MARTIGNONI, M. E.
Forestry Sciences Laboratory
U.S. Department of Agriculture
3200 Jefferson Way
Corvallis, Oregon 97331
RTLA 1645
MARTIN, K.
Department of Zoology
The University of Oklahoma
730 Van Vleet Oval, Room 222
Norman, Oklahoma 73069
RTLA 1739
MEARNS, A. J.
Southern California Coastal Water
Research Project
1500 East Imperial Highway
El Segundo, California 90245
RTLA 1708, 1709
MONDAY, B. L.
Mt. Pleasant Laboratories
Department of Agriculture
Launceston South, Tasmania 7250
RTLA 1812, 1813
-43-
NIELSEN, S. W.
Northeastern Research Center for
Wildlife Diseases
The University of Connecticut
Storrs, Connecticut 06268
RTLA 1819
OISHI, K.
Faculty of Fisheries
Hokkaido University
Hakodate, Japan
RTLA 1734
ORSANCO
W. L. Klein
Ohio River Valley Water
Sanitation Commission
414 Walnut Street
Cincinnati, Ohio 45202
RTLA 1806
OTTO, S. V.
State Laboratory
Maryland Department of
Natural Resources
Oxford, Maryland 21654
RTLA 1620-1640, 1735-1737,
1748-1766
OVERSTREET, R. M.
Gulf Coast Research Laboratory
East Beach
Ocean Springs, Mississippi 39564
RTLA 1663
PAL, J.
Department of Zoology
University of Kalyani
Kalyani 741235
West Bengal, India
RTLA 1738, 1815
RIEMER, W.
Baptist Hospital of Miami
8900 North Kendall Drive
Miami, Florida 33156
RTLA 1836
ROBINSON, P. T.
Zoological Society of San Diego
P. 0. Box 551
San Diego, California 92112
RTLA 1600
ROSE, F. L.
Department of Biological Sciences
Texas Tech University
Lubbock, Texas 79409
RTLA 1740
RUDDELL, C. L.
Virginia Institute of Marine
Science
Gloucester Point, Virginia 23062
RTLA 1605
SCHWAB, M.
Genetisches Institut
der Justus Liebig-Universitat
Heinrich-Buff-Ring 58-62
D-6300 Giessen, Germany
RTLA 1732, 1733
SCOTT, A. L.
Department of Fisheries
Auburn University
Auburn, Alabama 36830
RTLA 1652
SHERMAN, S.
23840 Jerome
Oak Park, Michigan 48237
RTLA 1723
SHIELDS, R. R.
J. Hillis Miller Health Center
P. 0. Box J-6
University of Florida
Gainesville, Florida 32610
RTLA 1617
SIGEL, M. M.
Department of Microbiology
School of Medicine
University of Miami
P. 0. Box 520875, Biscayne Annex
Miami, Florida 33152
RTLA 1836
SMITH, C. E.
Fish Cultural Development Center
U.S. Department of the Interior
Route 2, Box 333
Bozeman, Montana 59715
RTLA 1653-1657, 1814, 1837
-44-
STEVENSON, B. J.
Animal Health Laboratory
Palmerston North, New Zealand
RTLA 1648-1651, 1785, 1786
STICKNEY, R. R.
School of Natural BioSciences
Texas A & M University
College Station, Texas 77843
RTLA 1659
STROUD, R.
School of Veterinary Medicine
Oregon State University
Corvallis, Oregon 97331
RTLA 1713
TOMLJANOVICH, D.
Tennessee Valley Authority
Forestry, Fisheries, and
Wildlife Development
Norris, Tennessee 37828
RTLA 1747
VAN BANNING, P.
Rijksinstituut voor
Vlsserij onderzoek
Haringkade 1
IJmuiden 1620, The Netherlands
RTLA 1807-1809
VERHOEFF-DE FREMERY, R.
Hubrecht Laboratory
Uppsalalaan 8
Universiteitscentrum de „Uithof'*
Utrecht, The Netherlands
RTLA 1616, 1768, 1769
WOLF, H.
Fish Disease Laboratory
California Department of
Fish and Game
2111 Nimbus Road
Rancho Cordova, California 95670
RTLA 1615, 1643
WOLF, P. H.
N.S.W. State Fisheries
P. 0. Box N211
Grosvenor Street
Sydney 2000, Australia
RTLA 1608-1614, 1642, 1772,
1794-1799, 1825-1830
YEVICH, P. P.
Environmental Research Laboratory
U.S. Environmental Protection
Agency
South Ferry Road
Narragansett , Rhode Island 02882
RTLA 1694-1703, 1741-1746, 1818
ZAHURANEC, B. J.
Oceanic Biology Program
Office of Naval Research
Arlington, Virginia 22217
RTLA 1824
ZWERNER, D. E.
Virginia Institute of Marine Science
Gloucester Point, Virginia 23062
RTLA 1605
‘S??«S;t) I>ttRX«jI iahfo4H ^.'i^ayinffsfi:: j.iil!i
,.j., ,. 8xai. , A'rj.-xA^:x , f on -i^edx Aj'f')i ,
M-ltodifcfcfi. f - v^^joXoW DiwoO
rt; A r;.^r ' ' Ibvj^H 141 j?oiliiO
n<nx:,
.Hoawava'T?,
VXIiSJS; k'.Xfri^iiri? t«:ojrawl ItiA
. .3 .a ,}mvmm
'0fj-,1 1 i bh" sirtl-^-rlV
^ ■ ' S‘V0i£;ii' *" iji.rrl3',T(iV ,'iloloSl' 7s‘3XC!.a»£<oX0
. . . -fOdX AJTS
OKfiA;-' .1
' • ■ ... ’ ti'
ir.; Iw.si-.r ^ ,
Uir, M
'. .'.v '- L.' .' .•'." ,v<>r’.i
>'U: ;,■!.^:■^•). rAfJW^l, cf , ,
h.-v:ui:ui i:;r,:v,:»urot»'J4 . •
<;>^’:..-.j:ti, ^U''yU'wJ .116%
1^P0-l6'>'), 1735-“.r‘;
s, ■■:-• ?66
, .<. ' ,,;
C»:tf 'Cu4',', V Xv;'..,'i: ,ro’;: ''..•lo'-r ^i'), ..k't'v '
S -Sisv, f^«i,to4) . ’ , ,
c : . M n ??i; r ■;< ^ 'A < ..5 s . - i ,■. c- -I 3 ‘i^ *
'' ■'lA m3
PAL, ■ ' ‘ '.-,,,
■ y tvi'riiU r- k.-, '-.'-V
iOu,-.V< ■■•,■:■'„>,, '^j^'
West -Xl.; ' I. 'V
RTI.A ^■::A ' :,"
I', . T ’
nopeijw 'i-r ■■),,ua-'\'
HsOO W'-.t ^(,, ^ !jrivO' .a iwi;//
, i'iv'>l-Jr.\- ;..!i.5!., K'X;''’'!
R'7i.A ' V .,.:
mPhocHA r<a:an .l«idx-8Adx ajm
' ■ ' :^. :« .ywoixa
RUM.: lBW.yX3fl, lo. loofb?. ■
V4rj4iul«: InwtAflt^ A *4B3C5)T
'■W' I v;,r>.:e5i38'C’T aAX.9T ,«*xtXJt'.:;l3 ago.tXoD
Point » V4lt'v;',3^v^;>
«‘'P^.4j6a3
= .;j ,auo8TB
S'?.hl{A.a; I'itfiXoifcjai'i ytiircX^xaXS'V *:’o ioodi)3
' 'i.Y3*t;'t;r5'V.tf/TX s>,tri?, f.'o^^s'xU
attlt" JttfttifcM ■-' ii'v'isr;:)
eivi jum
!.-''6300 Onm-r.y
kXU . C! • .HliXVOMAUTM'lT
7XX'!jfO/f}j;A \j;».ti,«iV a-iBasimj.oT
SCXJT'', a i . tMjR ,’f'irjaotro'in-
,0?' :.'.irtn).fi; ' ji Vli5M>ra(S(.uXr'.vatI
.0.;, n/vi 0 i! A/;.v,Si;::SV‘'
i:,
r*«vr AJT^i
a.
■CwiH Pa.t'k , Ml,
PTIA
■ ■■uscfrt. k . 'i,
■ ^ i 1. S'Oi, ,..< :lvti Pi'A'lii
P.
5 v.fu "'
')./• ) AOO
,0W,X1^TIA« J;AV
•xoov :3wit3,lX8fj;isit4^
.ao sT^.b/j 0 tlwoa a i V
■..it','. abiiianX 'isR
''a'&nJtii-x.ad':l£.kW arTI’ ,OScH nab.lumll
i!0}U-\'08X text
sMfm?: u.'rt,
X, ntiv,.-
P. 0. J-6 jj ; Y’.i»X6iocfBJ: Xdoa*rdwH
“y ^.vjt Xn-k i.i 6 naAlsiBaqqlj
't-Ui
^7'i.A If, 17 arlT tXfba'jfXU
<?8\'I ,88X,f «dIdX /kJTK
8T.CEI., W, 'M. V ,
'of liil- k.! , , iolop^? . H < ''? JOW
itcJww>r <)f,' M/.tii ; YiTiodun’ocfAJ .ofifeaecQ dyX’E
U n i v« nlAl^ty 5 ' XW i .ItflftWfiJ ■Jtaqad iSl’irJO^l-MeO
'1. iO.i.-n' '5-^', A??,*!, 8.-,. -ftAisO bwnefielll
fu ',v,.j , Id:., hmoSi awcfiWiM .tllJI
X v'u.f.OtQciC i&lfifiolllEO ,ovobToD ori.ortsH
€Aa.t »eX8i Am
SHm-A'X:. n, ,. i
ill7 '$'7' %{)a V ' 39AX8'd®X'.<{n0»».Si?tr . W . 2 , W
Kof'Wttd 2^ acJx 3„'J.> XXSM xoa .0 .'X
'■' ' TfonavaoiO
•;. :• , sXX.ir.tj^‘o«.A:' i ooor Yonhx'd
' , 1 ' ; ' , }:xxi < SAd.t , Aldi-SOdJ AJ*m
) ' ; oiax-££8x
TEAR OUT ACCESSION SHEET
PLEASE SUBMIT TO:
Dr. John C, Harshbarger
Registry of Tumors in Lower Animals
National Museum of Natural History
Room W216-A
Smithsonian Institution
Washington, D.C,, 20560, USA
DATE RECD. _
CONTRIBUTOR'S NO.
RTLA NO. _
USNM NO. _ _
NIH HISTOPATH NO.
COMMON NAME _ FAMILY _ _ _
PHYLUM _ _ GENUS _
CLASS _ SPECIES _
ORDER _
CATEGORY: NEOPLASM _ INFLAMMATION _ INFECTION _ PARASITIC _ TOXIC
DEVELOPMENTAL _ TRAUMATIC _ NORMAL _ OTHER _
CONTRIBUTOR (NAME & ADDRESS): COLLECTOR (NAME & ADDRESS):
ITEMS SUBMITTED (QUANTITY):
GROSS MATERIAL _ PHOTOGRAPHS _
SLIDES _ REPRINTS _
BLOCKS _ OTHER _
ORIGIN OF ANIMAL: MARINE _ FRESHWATER _ ESTAURINE _ TERRESTRIAL
WHERE COLLECTED _
date collected _ SEX _ AGE _ STAGE OF LIFE CYCLE
HOW KILLED _ FIXATION _
GROSS DESCRIPTION _
MICROSCOPE DX
COMMENTS (e.g., possible exposure to chemical pollutants or infectious agents, in¬
cidence and duration of this condition in the population, etc.)
(Please use reverse side, if more space is needed)
TH3H8 ^OX^g^bpA gAgX
_ _
.on 2’;wjffiHr>'»oo
_ _ _ S^ OM ®
_ ,Ovl '
.CM ^TA'iOTBIH HIK
; , ' ^ ^ us>^iftc!d«^jill ,D wfipL ,ia
alftoaJtnA nawoj /il ^'ioatulT io
itttw3fcl4 irusBun
A-dlSW moo^l
wo.k:lu.ll.ianI n8i;«oarf^.tm3
ABtJf «0d<20S ,.D,(I ,/io3j{nlrinftW
•' yjiKM
.3MAW M0MMD3
8TJK30
/■'I
MUaYIH
iS?
mom 2
-
' B2AI0
VK
H3(l«0
^HXOT _ DITI8AnA<J _ M01TD3TOI . WOITANtt'fAMl _ _ MZAHOaW rYHOOarTAO
_ h^HTO JAWW _ OITAMTJAHT _ JAl'MaM*I0J3V3a
:(g8a«a«A.a mm) sopoajjoo :(agajia«AA hmai^.) .wuamwoo
“tfflMW i-}|
/ ^ , / iCVTIYWAUP) OamMaua 8M3TI
_ _ _ _ amASOOTOHSl _ _ _ , JAI^aTAM 830^3
_ ^ _ _ _ _ _ _ _ a-Haua
_ _ _ _ JJECHTO , _ f' _ cJJfOaTS
JAlflT82Wm’ _ _ 3MimjA3’a3 _ _ mAWHgriH’?! _ tJAKIilA TO WIDITO
_ _ _ _ _ _ a3T3J!J.T0'J aJiSHW
.., 3^I0Y0 331.1 30 30AT8 _ _ SOA _ _ _ a3T03XK!j 3'i’Aa
_ _ _ _ _ M0ITAXI3 _ _ _ (milX WOH
_ _ _ _ _ _ M0IX3,XTO8Ha SaOAO
■f-
xa 330Da0)!DrM
-«Jt ,f?lR38fl syoJ:3oa5fji: :fo tt.J«8:ruXXo<i Ifialc/arfo 0,1 a',iugoq«x» altfieapq , »s,9) 31’KJfl^KOO
(»o:)0 ,jioiaftloqoq ni noi^lbRoo alfb io'^nol^fi-atufs bn» sowobio
■*»
(X)sfaoa« ai sojsqa Biom iJ: ,i>bi8 samvatt seir aeflsH)
it'. .
AUG01
Live Music
Archive
Librivox
Free Audio
Metropolitan Museum
Cleveland
Museum of Art
Internet
Arcade
Console Living Room
Open Library
American
Libraries
TV News
Understanding
9/11